Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders

Light Suppresses Melatonin Secretion in Humans

1980 • 1,873 citations

Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor

2001 • 1,785 citations

Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker

1999 • 1,589 citations

Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression

2000 • 1,087 citations

A Phase Response Curve to Single Bright Light Pulses in Human Subjects

2003 • 949 citations

Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker

1989 • 936 citations

The basic physiology and pathophysiology of melatonin

2004 • 891 citations

The Efficacy of Light Therapy in the Treatment of Mood Disorders: A Review and Meta-Analysis of the Evidence

2005 • 853 citations

High Sensitivity of Human Melatonin, Alertness, Thermoregulation, and Heart Rate to Short Wavelength Light

2005 • 839 citations

Regulation of Adolescent Sleep: Implications for Behavior

2004 • 767 citations

High Sensitivity of the Human Circadian Melatonin Rhythm to Resetting by Short Wavelength Light

2003 • 746 citations

Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve

1992 • 690 citations

A human phase-response curve to light

1991 • 636 citations

Dose-response relationships for resetting of human circadian clock by light

1996 • 550 citations

The hypothalamic integrator for circadian rhythms

2005 • 512 citations

Entrainment of Free-Running Circadian Rhythms by Melatonin in Blind People

2000 • 481 citations

Salivary Melatonin as a Circadian Phase Marker: Validation and Comparison to Plasma Melatonin

1997 • 449 citations

Entrainment of the Human Circadian System by Light

2005 • 449 citations

The Endogenous Melatonin Profile as a Marker for Circadian Phase Position

1999 • 369 citations

The Human Phase Response Curve (Prc) to Melatonin is About 12 Hours out of Phase with the Prc to Light

1998 • 366 citations

Circadian Time of Morning Light Administration and Therapeutic Response in Winter Depression

2001 • 354 citations

Melatonin administration can entrain the free-running circadian system of blind subjects

2000 • 285 citations

Melatonin in mood disorders

2006 • 284 citations

A Circadian Signal of Change of Season in Patients With Seasonal Affective Disorder

2001 • 279 citations

Idiopathic Chronic Sleep Onset Insomnia in Attention‐Deficit/Hyperactivity Disorder: A Circadian Rhythm Sleep Disorder

2005 • 254 citations

Melatonin Administration to Blind People: Phase Advances and Entrainment

1991 • 251 citations

Efficacy of Melatonin Treatment in Jet Lag, Shift Work, and Blindness

1997 • 243 citations

Combinations of Bright Light, Scheduled Dark, Sunglasses, and Melatonin to Facilitate Circadian Entrainment to Night Shift Work

2003 • 240 citations

Bright light, dark and melatonin can promote circadian adaptation in night shift workers

2002 • 239 citations

Suppression of Nocturnal Plasma Melatonin and 6-Sulphatoxymelatonin by Bright and Dim Light in Man

1987 • 236 citations

Delayed sleep phase syndrome: A placebo‐controlled cross‐over study on the effects of melatonin administered five hours before the individual dim light melatonin onset

1998 • 223 citations

Phase-Dependent Treatment of Delayed Sleep Phase Syndrome with Melatonin

2005 • 204 citations

Melatonin for Chronic Sleep Onset Insomnia in Children: A Randomized Placebo-Controlled Trial

2001 • 201 citations

Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light

2004 • 201 citations

Aging Human Circadian Rhythms: Conventional Wisdom May Not Always Be Right

2005 • 196 citations

Melatonin Improves Health Status and Sleep in Children With Idiopathic Chronic Sleep-Onset Insomnia: A Randomized Placebo-Controlled Trial

2003 • 185 citations

Morning vs Evening Light Treatment for Winter Depression

1990 • 181 citations

Differential effects of light wavelength in phase advancing the melatonin rhythm

2004 • 171 citations

Disturbance of Endogenous Circadian Rhythm in Aging and Alzheimer Disease

2005 • 171 citations

Melatonin Is Able to Influence Its Secretion in Humans: Description of a Phase-Response Curve

1994 • 168 citations

A Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome

2001 • 164 citations

A human phase response curve for bright light pulses

1988 • 164 citations

Disturbance of Endogenous Circadian Rhythm in Aging and Alzheimer Disease

2005 • 162 citations

Profile of 24-h Light Exposure and Circadian Phase of Melatonin Secretion in Night Workers

2001 • 158 citations

The Effects of Low-Dose 0.5-mg Melatonin on the Free-Running Circadian Rhythms of Blind Subjects

2003 • 157 citations

SLEEP LOGS OF YOUNG ADULTS WITH SELF-SELECTED SLEEP TIMES PREDICT THE DIM LIGHT MELATONIN ONSET

2002 • 150 citations

Assessment and treatment of chronobiologic disorders using plasma melatonin levels and bright light exposure: the clock-gate model and the phase response curve.

1984 • 148 citations

The dim light melatonin onset following fixed and free sleep schedules

2005 • 146 citations

Melatonin, sleep, and circadian rhythms

2004 • 146 citations

Melatonin and the pineal gland: from basic science to clinical application

1992 • 145 citations

Effects of melatonin administration on daytime sleep after simulated night shift work

2001 • 143 citations

Demonstration of rapid light-induced advances and delays of the human circadian clock using hormonal phase markers

1994 • 142 citations

Seasonal Affective Disorder and Phototherapy

1985 • 140 citations

Phase-Amplitude Resetting of the Human Circadian Pacemaker via Bright Light: A Further Analysis

1994 • 140 citations

Clinical Aspects of Human Circadian Rhythms

2005 • 134 citations

Blocking Low-Wavelength Light Prevents Nocturnal Melatonin Suppression with No Adverse Effect on Performance during Simulated Shift Work

2005 • 133 citations

Alteration of Internal Circadian Phase Relationships after Morning versus Evening Carbohydrate-Rich Meals in Humans

2002 • 131 citations

Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study

2002 • 130 citations

Plasma Melatonin Circadian Rhythms during the Menstrual Cycle and after Light Therapy in Premenstrual Dysphoric Disorder and Normal Control Subjects

1997 • 127 citations

Immediate and Delayed Effects of Bright Light on Human Melatonin Production: Shifting “Dawn” and “Dusk” Shifts the Dim Light Melatonin Onset (DLMO)^a

1985 • 122 citations

Dim light melatonin onset and circadian temperature during a constant routine in hypersomnic winter depression

1993 • 114 citations

Complex Effects of Melatonin on Human Circadian Rhythms in Constant Dim Light

1997 • 113 citations

The phase shift hypothesis for bright light's therapeutic mechanism of action: theoretical considerations and experimental evidence.

1987 • 110 citations

Bright light, dark and melatonin can promote circadian adaptation in night shift workers

2002 • 98 citations

Midday exposure to bright light changes the circadian organization of plasma melatonin rhythm in humans

1997 • 98 citations

Phase shifting the human circadian clock using melatonin

1995 • 92 citations

Daytime naps in darkness phase shift the human circadian rhythms of melatonin and thyrotropin secretion

2000 • 91 citations

Circadian Rhythm Adaptation to Simulated Night Shift Work: Effect of Nocturnal Bright-Light Duration

1995 • 88 citations

High-intensity light for circadian adaptation to a 12-h shift of the sleep schedule

1992 • 87 citations

The Use of Chronobiotics in the Resynchronization of the Sleep–wake Cycle

2006 • 82 citations

Early versus late bedtimes phase shift the human dim light melatonin rhythm despite a fixed morning lights on time

2004 • 82 citations

Posttraumatic delayed sleep phase syndrome

2000 • 78 citations

Adaptation of the melatonin rhythm in human subjects following nightshift work in Antarctica

1991 • 75 citations

The Dim Light Melatonin Onset, Melatonin Assays and Biological Rhythm Research in Humans

1999 • 75 citations

Prediction of melatonin efficacy by pretreatment dim light melatonin onset in children with idiopathic chronic sleep onset insomnia

2005 • 74 citations

Conflicting Bright Light Exposure during Night Shifts Impedes Circadian Adaptation

1997 • 74 citations

Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome

2000 • 71 citations

Phase‐shifts in melatonin, 6‐sulphatoxymelatonin and alertness rhythms after treatment with moderately bright light at night

1994 • 69 citations

Melatonin‐Responsive Headache in Delayed Sleep Phase Syndrome: Preliminary Observations

1998 • 68 citations

Sleep and circadian rhythms

1991 • 66 citations

Eventual Entrainment of the Human Circadian Pacemaker by Melatonin is Independent of the Circadian Phase of Treatment Initiation: Clinical Implications

2004 • 63 citations

Effects of light exposure and sleep displacement on dim light melatonin onset

1999 • 56 citations

Evening melatonin and bright light administration induce additive phase shifts in dim light melatonin onset

2004 • 53 citations

Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion

2006 • 48 citations

Salivary and plasma measures of dim light melatonin onset (DLMO) in patients with rapid cycling bipolar disorder

1996 • 47 citations

Are Modifications of Melatonin Circadian Rhythm in the Middle Years of Life Related to Habitual Patterns of Light Exposure?

2005 • 43 citations

Rapid phase advance of the 24-h melatonin profile in response to afternoon dark exposure

1998 • 42 citations

Diagnosis and Assessment of Sleep and Circadian Rhythm Disorders

2005 • 41 citations

Alteration of Internal Circadian Phase Relationships after Morning versus Evening Carbohydrate-Rich Meals in Humans

2002 • 38 citations

Melatonin for Chronic Whiplash Syndrome with Delayed Melatonin Onset

2001 • 35 citations

Contemporaneous melatonin administration modifies the circadian response to nocturnal bright light stimuli

1997 • 28 citations

Light and Plasma Melatonin Rhythm in Humans

1997 • 28 citations

Effects of evening light conditions on salivary melatonin of Japanese junior high school students

2004 • 28 citations

The validity and feasibility of saliva melatonin assessment in the elderly

2003 • 27 citations

The effects of shifting sleep two hours within a fixed photoperiod

1991 • 25 citations

Treatment of seasonal affective disorder: Unipolar versus bipolar differences

2004 • 24 citations

Testing the Hypothesis of a Circadian Phase Disturbance Underlying Depressive Mood in Nonseasonal Depression

1998 • 23 citations

Effects of indirect light and propranolol on melatonin levels in normal human subjects

1998 • 21 citations

Regulation of the circadian rhythm in pineal melatonin production.

1985 • 9 citations

Influence of Melatonin on Quality of Life in Patients with Chronic Fatigue and Late Melatonin Onset

2002 • 8 citations

A week of simulated night work delays salivary melatonin onset.

2001 • 7 citations

Mechanisms of Action in the Prevention of Recurrent Mood Disorders

2004 • 5 citations

Understanding seasonal affective disorder.

2005 • 3 citations