Regulation of nitrogen metabolism and gene expression in fungi

Gene Regulation for Higher Cells: A Theory

1969 • 2,022 citations

Degradation of purines and pyrimidines by microorganisms

1976 • 509 citations

Nitrogen metabolite repression in Aspergillus nidulans

1973 • 431 citations

Regulation of Gene Expression

1968 • 417 citations

GENETIC STUDIES OF NITRATE ASSIMILATION IN ASPERGILLUS NIDULANS

1979 • 253 citations

Autogenous Regulation of Gene Expression

1974 • 201 citations

The Origins of Gene Instability in Yeast

1980 • 198 citations

Biochemical genetics of Neurospora crassa conidial germination

1976 • 140 citations

The subunit structure of the arom multienzyme complex of Neurospora crassa. A possible pentafunctional polypeptide chain

1977 • 133 citations

Genetics and physiology of proline utilization in Saccharomyces cerevisiae: enzyme induction by proline

1979 • 126 citations

A gene cluster in Aspergillus nidulans with an internally located cis-acting regulatory region

1975 • 118 citations

Regulation of Intracellular and Extracellular Neutral and Alkaline Proteases in Aspergillus nidulans

1973 • 118 citations

The induction and repression of the enzymes of purine breakdown in Aspergillus nidulans

1968 • 115 citations

Ammonia assimilation in Saccharomyces cerevisiae as mediated by the two glutamate dehydrogenases

1974 • 113 citations

Ammonium Repression of Extracellular Protease in Aspergillus nidulans

1972 • 110 citations

Activation of Transcription of hut DNA by Glutamine Synthetase

1974 • 101 citations

Implications of some genetic control mechanisms in Neurospora

1979 • 101 citations

The genetic analysis of regulation of amidase synthesis inAspergillus nidulans

1970 • 100 citations

Autoregulation of the Synthesis of Nitrate Reductase in Aspergillus nidulans

1969 • 98 citations

A cluster-gene: Evidence for one gene, one polypeptide, five enzymes

1977 • 98 citations

Metabolite Distribution in Cells

1972 • 98 citations

Ammonium Regulation in Aspergillus nidulans

1973 • 91 citations

Nitrogen metabolite repression of nitrate reductase in Neurospora crassa

1979 • 90 citations

Integrator gene in Aspergillus nidulans

1976 • 90 citations

Control of the synthesis of a single enzyme by multiple regulatory circuits in Neurospora crassa.

1975 • 83 citations

The Participation of the Anabolic Glutamate Dehydrogenase in the Nitrogen Catabolite Repression of Arginase in Saccharomyces cerevisiae

1974 • 83 citations

THE ISOLATION AND CHARACTERIZATION OF MUTANTS DEFECTIVE IN NITRATE ASSIMILATION IN NEUROSPORA CRASSA

1980 • 80 citations

POSITIVE REGULATION IN A EUKARYOTE, A STUDY OF THE uaY GENE OF ASPERGILLUS NIDULANS: I. CHARACTERIZATION OF ALLELES, DOMINANCE AND COMPLEMENTATION STUDIES, AND A FINE STRUCTURE MAP OF THE uaY - oxpA CLUSTER

1982 • 73 citations

Initiator constitutive mutation with an ‘up-promoter’ effect in Aspergillus nidulans

1975 • 73 citations

Biochemical studies on the Nit mutants of Neurospora crassa

1976 • 68 citations

Deletion mapping of theniiAniaD gene region ofAspergillus nidulans

1979 • 63 citations

Identification of the product of the major regulatory gene of the nitrogen control circuit of Neurospora crassa as a nuclear DNA-binding protein.

1981 • 58 citations

Genetic and metabolic control of the purine catabolic enzymes of Neurospora crassa

1975 • 57 citations

Multiple independent control mechanisms affecting the acetamidase of Aspergillus nidulans

1978 • 55 citations

Nitrogen metabolite repression of nitrate reductase in Neurospora crassa: effect of the gln-1a locus

1979 • 52 citations

Nitrogen regulation of amino acid catabolism in Neurospora crassa

1978 • 51 citations

The role of glutamine synthetase and glutamine metabolism in nitrogen metabolite repression, a regulatory phenomenon in the lower eukaryote Neurospora crassa

1980 • 50 citations

Kinetics of induced and repressed enzyme synthesis in Saccharomyces cerevisiae

1975 • 50 citations

A mutation in Aspergillus nidulans which affects the regulation of nitrite reductase and is tightly linked to its structural gene

1977 • 49 citations

Neurospora crassa glutamine synthetase. Purification by affinity chromatography and characterization of subunit structure.

1976 • 48 citations

Regulation, purification, and properties of xanthine dehydrogenase in Neurospora crassa.

1978 • 47 citations

Nitrogen Repression of the Allantoin Degradative Enzymes in Saccharomyces cerevisiae

1974 • 47 citations

Regulation of two extracellular proteases of Neurospora crassa by induction and by carbon-nitrogen and sulfur-metabolite repression

1975 • 47 citations

The Organization, Function, and Evolution of Gene Clusters in Eucaryotes

1978 • 46 citations

Regulation of Proline Transport in Aspergillus nidulans

1980 • 46 citations

NADH-dependent glutamate synthase and nitrogen metabolism in Neurospora crassa

1980 • 45 citations

FINE-STRUCTURE MAPPING OF THE ACETAMIDASE STRUCTURAL GENE AND ITS CONTROLLING REGION IN ASPERGILLUS NIDULANS

1979 • 44 citations

Efficient cap-dependent translation of polycistronic prokaryotic mRNAs is restricted to the first gene in the operon

1979 • 44 citations

COMPARTMENTATION AND REGULATION OF FUNGAL METABOLISM: GENETIC APPROACHES

1975 • 43 citations

Physiological characterization of a Neurospora crassa mutant with impaired regulation of nitrate reductase

1980 • 43 citations

Sequence of molecular events involved in induction of allophanate hydrolase

1976 • 42 citations

Lactam utilisation in Aspergillus nidulans: Evidence for a fourth gene under the control of the integrator gene intA

1978 • 39 citations

A mutation defective in the xanthine alternative pathway of Aspergillus nidulans

1978 • 38 citations

Regulation of the purine catabolic enzymes in Neurospora crassa

1975 • 38 citations

Nitrogen Regulation of Glutamine Synthetase in Neurospora crassa

1978 • 38 citations

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. Peptic and chymotryptic peptides and the complete sequence

1975 • 37 citations

Nitrogen source regulates glutamine synthetase mRNA levels in Neurospora crassa

1978 • 36 citations

Relation between structure and function of Neurospora crassa glutamine synthetase

1980 • 35 citations

Heterogeneity of glutamine synthetase polypeptides in Neurospora crassa.

1980 • 35 citations

Immunoelectrophoretic determination of nitrate reductase in Neurospora crassa

1979 • 34 citations

Studies of partially repressed mutants at the tamA and areA loci in Aspergillus nidulans

1975 • 34 citations

Nickel Requirement of a Urease-deficient Mutant in Aspergillus nidulans

1980 • 33 citations

Nitrogen regulation of uricase synthesis in Neurospora crassa

1979 • 32 citations

The nature of an initiator constitutive mutation in Aspergillus nidulans

1978 • 32 citations

Genetics and physiology of Neurospora crassa glutamine auxotrophs

1978 • 32 citations

Do the tightly linked structural genes for nitrate and nitrite reductases in Aspergillus nidulans form an operon? Evidence from an insertional translocation which separates them

1979 • 30 citations

Reduced expression of a distal gene of the prn gene cluster in deletion mutants of Aspergillus nidulans: Genetic evidence for a dicistronic messenger in an eukaryote

1978 • 29 citations

Neurospora crassa glutamine synthetase. Translation of specific messenger ribonucleic acid in a cell-free system derived from rabbit reticulocytes.

1977 • 28 citations

Regulation of Glutamate Dehydrogenases in nit-2 and am Mutants of Neurospora crassa

1979 • 28 citations

Glutamate synthase levels in Neurospora crassa mutants altered with respect to nitrogen metabolism.

1981 • 28 citations

Allantoate transport in Saccharomyces cerevisiae

1979 • 28 citations

Glutamine Metabolism in Nitrogen-starved Conidia of Neurospora crassa

1979 • 27 citations

Induction and inhibition of the allantoin permease in Saccharomyces cerevisiae

1978 • 27 citations

Mutants of Aspergillus nidulans lacking nicotinamide adenine dinucleotide-specific glutamate dehydrogenase

1976 • 26 citations

Demonstration in vitro of two intracellular inactivators of nitrate reductase from Neurospora

1978 • 26 citations

Organization and expression of a two-gene cluster in the arginine biosynthesis of Saccharomyces cerevisiae

1979 • 26 citations

Neurospora crassa glutamine synthetase. Role of enzyme synthesis and degradation on the regulation of enzyme concentration during exponential growth

1977 • 25 citations

Repression of nitrate reductase in Neurospora studied by using L-methionine-DL-sulfoximine and glutamine auxotroph gln-1b

1980 • 25 citations

Demonstration of de novo synthesis of Neurospora crassa nitrate reductase during induction.

1980 • 25 citations

Genetic and metabolic regulation of purine base transport in Neurospora crassa

1976 • 25 citations

Clustering of the Genes for Allantoin Degradation in Saccharomyces cerevisiae

1974 • 24 citations

The molecular basis of an osmotically reparable mutant of Neurospora crassa producing unstable glutamate dehydrogenase

1977 • 24 citations

A mutation, adjacent to gene amdS, defining the site of action of positive-control gene amdR in Aspergillus nidulans

1980 • 24 citations

A CLUSTER OF THREE GENES RESPONSIBLE FOR ALLANTOIN DEGRADATION IN SACCHAROMYCES CEREVISIAE

1979 • 22 citations

The Genetics of the Molybdenum-containing Enzymes

1980 • 22 citations

Regulation of Neurospora crassa Glutamine Synthetase by the Carbon and Nitrogen Source

1980 • 21 citations

Purification and characterization of uricase, a nitrogen-regulated enzyme, from Neurospora crassa

1980 • 21 citations

Stability of messenger RNA for nitrate reductase in Neurospora crassa

1978 • 20 citations

The regulation of the decay of nitrate reductase Evidence for the existence of at least two mechanisms of decay

1978 • 16 citations

Positive regulation in a eukaryote, a study of the uaY gene of Aspergillus nidulans

1981 • 15 citations

Developmental-stage-dependent adenine transport in Neurospora crassa

1977 • 15 citations

Mutants affecting histidine utilization inAspergillus nidulans

1975 • 14 citations

NEW MUTATIONAL VARIANTS OF NEUROSPORA NADP-SPECIFIC GLUTAMATE DEHYDROGENASE

1980 • 12 citations

Product induction of purine hydroxylase II in Aspergillus nidulans

1979 • 12 citations

AN UNSTABLE ALLELE OF THE am LOCUS OF NEUROSPORA CRASSA

1979 • 10 citations

Factors influencing the observed half-lives of specific synthetic capacities in Saccharomyces cerevisiae

1978 • 8 citations

NADP-Specific glutamate dehydrogenase is not involved in repression of yeast sporulation by ammonia

1979 • 2 citations