Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.

2001 • 599 citations

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.

1990 • 567 citations

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

2008 • 526 citations

Endocytosis and Sorting of ErbB2 and the Site of Action of Cancer Therapeutics Trastuzumab and Geldanamycin

2004 • 461 citations

Isolation of Picomolar Affinity Anti-c-erbB-2 Single-chain Fv by Molecular Evolution of the Complementarity Determining Regions in the Center of the Antibody Binding Site

1996 • 380 citations

A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier.

1990 • 343 citations

Isolation of High-affinity Monomeric Human Anti-c-erbB-2 Single chain Fv Using Affinity-driven Selection

1996 • 295 citations

Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors.

1989 • 257 citations

Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size

2010 • 235 citations

Increased affinity leads to improved selective tumor delivery of single-chain Fv antibodies.

1998 • 234 citations

Affinity and Avidity in Antibody-Based Tumor Targeting

2009 • 219 citations

Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells.

1996 • 213 citations

Quantitative Analysis of HER2-mediated Effects on HER2 and Epidermal Growth Factor Receptor Endocytosis

2003 • 178 citations

The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels.

1994 • 144 citations

Effect of Target Dynamics on Pharmacokinetics of a Novel Therapeutic Antibody against the Epidermal Growth Factor Receptor: Implications for the Mechanisms of Action

2006 • 126 citations

Theoretic Criteria for Antibody Penetration into Solid Tumors and Micrometastases

2007 • 124 citations

Regulation of Antibody-Dependent Cellular Cytotoxicity by IgG Intrinsic and Apparent Affinity for Target Antigen

2007 • 120 citations

Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts

2008 • 117 citations

PEGylation and Multimerization of the Anti-p185HER-2 Single Chain Fv Fragment 4D5

2006 • 117 citations

The fate of antibodies bound to the surface of tumor cells in vitro.

1992 • 104 citations

Processing of antibody-radioisotope conjugates after binding to the surface of tumor cells

1994 • 99 citations

Avidity-Mediated Enhancement of In vivo Tumor Targeting by Single-Chain Fv Dimers

2006 • 97 citations

Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids

2008 • 96 citations

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments

1992 • 95 citations

Engineered affinity proteins for tumour‐targeting applications

2009 • 73 citations

High Shed Antigen Levels within Tumors: An Additional Barrier to Immunoconjugate Therapy

2008 • 59 citations

Comparisons between two monoclonal antibodies that bind to the same antigen but have differing affinities: uptake kinetics and 125I-antibody therapy efficacy in multicell spheroids.

1992 • 45 citations

Deleted Work

1955 • 0 citations