In vitro Replication of Scrapie Agent in a Neuronal Model: Infection of PC12 Cells

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Unconventional Viruses and the Origin and Disappearance of Kuru

1977 • 897 citations

Characterization and isolation of proteolytically modified nerve growth factor

1976 • 677 citations

Reconstituted rattail collagen used as substrate for tissue cultures on coverslips in Maximow slides and roller tubes.

1958 • 660 citations

Release, storage and uptake of catecholamines by a clonal cell line of nerve growth factor (NGF) responsive pheochromocytoma cells

1977 • 410 citations

Synthesis, storage and release of acetylcholine by a noradrenergic pheochromocytoma cell line

1977 • 252 citations

Neuronal spread of scrapie agent and targeting of lesions within the retino-tectal pathway

1982 • 143 citations

Release of [3H]norepinephrine from a clonal line of pheochromocytoma cells (PC12) by nicotinic cholinergic stimulation

1977 • 141 citations

Pathogenesis of Mouse Scrapie: Evidence for Neural Spread of Infection to the CNS

1980 • 115 citations

The effects of nerve growth factor on acetylcholinesterase and its multiple forms in cultures of rat PC12 pheochromocytoma cells: Increased total specific activity and appearance of the 16 S molecular form

1980 • 108 citations

Genetical control of the concentration of ME7 scrapie agent in the brain of mice

1969 • 105 citations

Evidence for the Multiplication of Scrapie Agent in Cell Culture

1970 • 94 citations

Pathogenesis of Mouse Scrapie: Patterns of Agent Replication in Different Parts of the CNS following Intraperitoneal Infection

1982 • 90 citations

Scrapie: Pathogenesis in Inbred Mice: An Assessment of Host Control and Response Involving Many Strains of Agent

1977 • 84 citations

Preclinical Changes in Weight of Scrapie-lnfected Mice as a Function of Scrapie Agent-Mouse Strain Combination

1984 • 76 citations

The pathogenesis of scrapie in mice.

1976 • 76 citations

Nerve growth factor-induced increase in saxitoxin binding to rat PC12 pheochromocytoma cells

1982 • 75 citations

Effect of Mouse Peritoneal Macrophages on Scrapie Infectivity during Extended in vitro Incubation

1982 • 73 citations

Observations on the Comparative Infectivity of Cellular Fractions Derived from Homogenates of Mouse-scrapie Brain

1963 • 55 citations

Multiplication of Scrapie Agent in Cell Culture

1970 • 54 citations

Infection of a cell line of mouse L fibroblasts with scrapie agent

1976 • 46 citations

Neural pathogenesis of experimental scrapie after intraocular inoculation of hamsters

1983 • 41 citations

In‐vitro growth of pieces of brain from scrapie‐affected mice

1967 • 30 citations

Early Inhibition of Acetylcholinesterase and Choline Acetyltransferase Activity in Herpes simplex Virus Type 1 Infection of PC12 Cells

1984 • 27 citations

Cultural Characters of Scrapie Mouse Brain

1965 • 25 citations

Absence of Eclipse Phase in Scrapie Mice

1972 • 23 citations

Replication of thymidine kinase deficient herpes simplex virus type 1 in neuronal cell culture: Infection of the PC 12 cell

1983 • 14 citations

Scrapie in the mouse.

1976 • 13 citations

Slow virus diseases of the central nervous system.

1974 • 11 citations

Preservation of Catecholamine Uptake and Release in Herpes Simplex Virus Type 1-infected PC12 Cells

1983 • 11 citations

Failure of the Scrapie Agent to Replicate in L5178Y Mouse Leukaemic Cells

1972 • 7 citations

Viral Properties of Scrapie

1971 • 5 citations

Scrapie in the Mouse. Patterns of Progress

1977 • 5 citations