Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat

1979 • 1,325 citations

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

1991 • 942 citations

Molecular Mechanisms of Local Anesthesia

1990 • 840 citations

The Up-and-Down Method for Small Samples

1965 • 795 citations

Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.

1992 • 785 citations

Painful neuropathy: altered central processing maintained dynamically by peripheral input

1992 • 770 citations

Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications

1979 • 765 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

1991 • 616 citations

Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection

1990 • 545 citations

Dynamic and static components of mechanical hyperalgesia in human hairy skin

1992 • 510 citations

Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin

1989 • 510 citations

Relief of post-herpetic neuralgia with the Symbol receptor antagonist ketamine: A double-blind, cross-over comparison with morphine and placebo

1994 • 483 citations

Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain

1994 • 469 citations

Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.

1997 • 362 citations

Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin

1995 • 358 citations

The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input

1996 • 352 citations

NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride

1996 • 298 citations

Different patterns of hyperalgesia induced by experimental inflammation in human skin

1994 • 285 citations

Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat

1982 • 273 citations

Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats

1997 • 250 citations

Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy

1993 • 246 citations

Interaction of the Chiral Forms of Ketamine with Opioid, Phencyclidine, σ and Muscarinic Receptors

1995 • 243 citations

Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats

1996 • 227 citations

Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary hyperalgesia in man: a double-blind, cross-over comparison with morphine and placebo

1997 • 227 citations

Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test

1997 • 205 citations

Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury

1987 • 188 citations

Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects

1995 • 182 citations

Intravenous Infusion of the NMDA Antagonist, Ketamine, in Chronic Posttraumatic Pain with Allodynia

1995 • 173 citations

The effect of pre- versus postinjury infiltration with lidocaine on thermal and mechanical hyperalgesia after heat injury to the skin

1993 • 154 citations

Effect of systemic N-methyl-D-aspartate receptor antagonist (ketamine) on primary and secondary hyperalgesia in humans

1996 • 144 citations

Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin

1989 • 139 citations

Local treatment with the N-methyl-d-aspartate receptor antagonist ketamine, inhibit development of secondary hyperalgesia in man by a peripheral action

1997 • 131 citations

Peripheral Analgesic Effects of Ketamine in Acute Inflammatory Pain

1998 • 98 citations

MOLECULAR ACTIONS OF RACEMIC KETAMINE ON HUMAN CNS SODIUM CHANNELS

1992 • 75 citations

Some Pharmacologic Similarities of Ketamine, Lidocaine, and Procaine

1973 • 74 citations

Development of secondary hyperalgesia following non-painful thermal stimulation of the skin: a psychophysical study in man

1993 • 59 citations

Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans

2000 • 49 citations

The Effects of Ketamine on the Excitation and Inhibition of Dorsal Horn WDR Neuronal Activity Induced by Bradykinin Injection into the Femoral Artery in Cats after Spinal Cord Transection

1993 • 27 citations

Repetitive intradermal capsaicin: differential effect on pain and areas of allodynia and punctate hyperalgesia

2000 • 23 citations

INTRACUTANEOUS FENTANYL AND KETAMINE DO NOT ALTER CAPSAICIN INDUCED SECONDARY HYPERALGESIA

1998 • 1 citations