The pulmonary physician in critical care * 7: Ventilator induced lung injury

Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome

2000 • 11,795 citations

Handbook of Physiology.

1960 • 10,428 citations

Ventilator-induced Lung Injury

1998 • 2,270 citations

Effect of Mechanical Ventilation on Inflammatory Mediators in Patients With Acute Respiratory Distress Syndrome

1999 • 1,816 citations

High Inflation Pressure Pulmonary Edema: Respective Effects of High Airway Pressure, High Tidal Volume, and Positive End-expiratory Pressure

1988 • 1,647 citations

Stress distribution in lungs: a model of pulmonary elasticity.

1970 • 1,337 citations

Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model.

1997 • 1,327 citations

Tidal ventilation at low airway pressures can augment lung injury.

1994 • 1,233 citations

Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure.

1974 • 932 citations

MALIGNANT INTERSTITIAL EMPHYSEMA OF THE LUNGS AND MEDIASTINUM AS AN IMPORTANT OCCULT COMPLICATION IN MANY RESPIRATORY DISEASES AND OTHER CONDITIONS

1944 • 930 citations

Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome

1990 • 899 citations

Evaluation of a Ventilation Strategy to Prevent Barotrauma in Patients at High Risk for Acute Respiratory Distress Syndrome

1998 • 874 citations

Pressure-Volume Curve of Total Respiratory System in Acute Respiratory Failure: Computed Tomographic Scan Study

1987 • 860 citations

Multiple System Organ Failure

1998 • 827 citations

Tidal Volume Reduction for Prevention of Ventilator-induced Lung Injury in Acute Respiratory Distress Syndrome

1998 • 776 citations

Pulmonary Surfactant Therapy

1993 • 659 citations

Beneficial effects of the "open lung approach" with low distending pressures in acute respiratory distress syndrome. A prospective randomized study on mechanical ventilation.

1995 • 627 citations

Immunomodulatory functions of surfactant

1997 • 589 citations

Manual Ventilation with a Few Large Breaths at Birth Compromises the Therapeutic Effect of Subsequent Surfactant Replacement in Immature Lambs

1997 • 587 citations

Aerosolized Surfactant in Adults with Sepsis-Induced Acute Respiratory Distress Syndrome

1996 • 578 citations

Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats

1987 • 574 citations

Surfactant and the Adult Respiratory Distress Syndrome

1993 • 554 citations

Mechanical Ventilation

1993 • 546 citations

Stress failure in pulmonary capillaries

1991 • 516 citations

Mechanical Ventilation Affects Local and Systemic Cytokines in an Animal Model of Acute Respiratory Distress Syndrome

1999 • 508 citations

Do Clinical Markers of Barotrauma and Oxygen Toxicity Explain Interhospital Variation in Rates of Chronic Lung Disease?

2000 • 501 citations

Total Respiratory Pressure-Volume Curves in the Adult Respiratory Distress Syndrome

1984 • 463 citations

Invited Review: Mechanisms of ventilator-induced lung injury: a perspective

2000 • 459 citations

Regional Effects and Mechanism of Positive End-Expiratory Pressure in Early Adult Respiratory Distress Syndrome

1993 • 448 citations

Severe impairment in lung function induced by high peak airway pressure during mechanical ventilation. An experimental study.

1987 • 444 citations

Chest wall restriction limits high airway pressure-induced lung injury in young rabbits

1989 • 422 citations

The Pressure–Volume Curve Is Greatly Modified by Recruitment

1998 • 409 citations

Lung Volume Maintenance Prevents Lung Injury during High Frequency Oscillatory Ventilation in Surfactant-deficient Rabbits

1988 • 402 citations

Comparison of conventional and high-frequency ventilation: oxygenation and lung pathology

1983 • 351 citations

Reactive oxygen species in acute lung injury

1998 • 336 citations

Hyperventilation Induces Release of Cytokines from Perfused Mouse Lung

1998 • 336 citations

High lung volume increases stress failure in pulmonary capillaries

1992 • 320 citations

Histopathologic Pulmonary Changes from Mechanical Ventilation at High Peak Airway Pressures

1991 • 317 citations

Pulmonary Oxygen Toxicity

1983 • 312 citations

Impairment of Lung and Chest Wall Mechanics in Patients with Acute Respiratory Distress Syndrome

1997 • 298 citations

The stability of peripheral airways

1970 • 296 citations

Pulmonary Oxygen Toxicity

1985 • 293 citations

Mechanical force-induced signal transduction in lung cells

1999 • 286 citations

Effect of granulocyte depletion in a ventilated surfactant-depleted lung

1987 • 276 citations

The open lung during small tidal volume ventilation: Concepts of recruitment and "optimal" positive end-expiratory pressure

1999 • 269 citations

Effect of Mechanical Ventilation on Inflammatory Mediators in Patients with Acute Respiratory Distress Syndrome: A Randomized Controlled Trial

2000 • 267 citations

Ultrastructural appearances of pulmonary capillaries at high transmural pressures

1991 • 257 citations

Positive end-expiratory pressure

1973 • 253 citations

Incidence of pulmonary barotrauma in a medical ICU

1983 • 253 citations

Increased microvascular permeability in dog lungs due to high peak airway pressures

1984 • 250 citations

Effect of mechanical ventilation strategy on dissemination of intratracheally instilled Escherichia coli in dogs

1997 • 240 citations

Severe Impairment in Lung Function Induced by High Peak Airway Pressure during Mechanical Ventilation

2015 • 234 citations

Lung overexpansion increases pulmonary microvascular protein permeability in young lambs

1990 • 231 citations

Acute Respiratory Distress Syndrome: CT Abnormalities at Long-term Follow-up

1999 • 226 citations

Mechanical ventilation-induced pulmonary edema. Interaction with previous lung alterations.

1995 • 225 citations

Effects of Decreased Respiratory Frequency on Ventilator-induced Lung Injury

2000 • 221 citations

Surfactant dysfunction makes lungs vulnerable to repetitive collapse and reexpansion.

1997 • 221 citations

Inflammatory chemical mediators during conventional ventilation and during high frequency oscillatory ventilation.

1994 • 208 citations

Epidemiology of Acute Lung Injury and ARDS

1999 • 205 citations

Effects of surface tension and viscosity on airway reopening

1990 • 205 citations

Histologic aspects of pulmonary barotrauma in critically ill patients with acute respiratory failure

1993 • 204 citations

Lung Development and Function in Preterm Infants in the Surfactant Treatment Era

2000 • 203 citations

High-frequency Oscillatory Ventilation

2000 • 199 citations

The Relation of Pneumothorax and Other Air Leaks to Mortality in the Acute Respiratory Distress Syndrome

1998 • 198 citations

Is outcome from ARDS related to the severity of respiratory failure?

1997 • 193 citations

Ventilator-induced lung injury leads to loss of alveolar and systemic compartmentalization of tumor necrosis factor-α

2000 • 182 citations

Adverse Ventilatory Strategy Causes Pulmonary-to-Systemic Translocation of Endotoxin

2000 • 178 citations

Effects of positive end-expiratory pressure on hyaline membrane formation in a rabbit model of the neonatal respiratory distress syndrome

1988 • 169 citations

Regulation of lung surfactant secretion

1990 • 153 citations

Increased surface tension favors pulmonary edema formation in anesthetized dogs' lungs.

1979 • 150 citations

Consequences of Vascular Flow on Lung Injury Induced by Mechanical Ventilation

1998 • 148 citations

Intratracheal anti-tumor necrosis factor-α antibody attenuates ventilator-induced lung injury in rabbits

1999 • 145 citations

Lung inflation, lung solute permeability, and alveolar edema

1982 • 138 citations

Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lungs

1998 • 137 citations

Randomized comparison of high-frequency ventilation with high-rate intermittent positive pressure ventilation in preterm infants with respiratory failure

1999 • 135 citations

Regional Expansion of Oleic Acid–Injured Lungs

1999 • 134 citations

Effect of Il-1 Blockade on Inflammatory Manifestations of Acute Ventilator-Induced Lung Injury in a Rabbit Model

1995 • 133 citations

Lung overinflation without positive end-expiratory pressure promotes bacteremia after experimental Klebsiella pneumoniae inoculation

1998 • 130 citations

HIGH PEEP DECREASES HYALINE MEMBRANE FORMATION IN SURFACTANT DEFICIENT LUNGS

1987 • 128 citations

Mechanical ventilation increases microvascular permeability in oleic acid-injured lungs

1990 • 126 citations

Is airway closure caused by a liquid film instability?

1989 • 124 citations

Changes in Intubation Rates and Outcome of Very Low Birth Weight Infants: A Population-based Study

1996 • 114 citations

Bronchopulmonary Dysplasia: Twenty-five Years Later

1992 • 109 citations

Spontaneous resolution of pulmonary edema caused by short periods of cyclic overinflation

1992 • 107 citations

Regional effects and mechanism of positive end-expiratory pressure in early adult respiratory distress syndrome

1993 • 92 citations

Open lung approach

2003 • 82 citations

Long-term follow-up of survivors of acute lung injury: Lack of effect of a ventilation strategy to prevent barotrauma

1999 • 82 citations

Measurement of band offsets and interface charges by the C–V matching method

1998 • 81 citations

High tidal volume ventilation produces increased lung water in oleic acid-injured rabbit lungs

1989 • 78 citations

Airway reopening pressure in isolated rat lungs

1994 • 78 citations

Mechanical Ventilation-induced Air-Space Enlargement during Experimental Pneumonia in Piglets

2001 • 74 citations

Physiological basis of ventilatory support

1998 • 72 citations

Alterations of the Endogenous Surfactant System in Septic Adult Rats

1997 • 64 citations

Treatment of Bronchopleural Fistula during Continuous Positive Pressure Ventilation

1976 • 61 citations

Physiology and Musical Instruments

1969 • 60 citations

SURFACTANT AND ADULT RESPIRATORY DISTRESS SYNDROME

1993 • 60 citations

Healthy lungs tolerate repetitive collapse and reopening during short periods of mechanical ventilation

1995 • 56 citations

Increased sensitivity to mechanical ventilation after surfactant inactivation in young rabbit lungs

1992 • 54 citations

Polypoid bronchial lesions due to Scedosporium apiospermum in a patient with Mycobacterium avium complex pulmonary disease

1998 • 54 citations

Biological effects of hypercapnia

2000 • 51 citations

"Respirator lung": a misnomer.

1971 • 49 citations

Lung inflation can cause pulmonary edema in zone I of in situ dog lungs

1980 • 47 citations

Effects of lung inflation on alveolar epithelial solute and water transport properties

1982 • 43 citations

Characterizing alterations in the pulmonary surfactant system in a rat model of Pseudomonas aeruginosa pneumonia

1998 • 29 citations

Are Pulmonary Capillaries Susceptible to Mechanical Stress?

1994 • 19 citations

High Frequency oscillatory ventilation

1999 • 18 citations

Effects of intermittent positive-pressure ventilation on lungs of normal rabbits.

1980 • 11 citations

Effect of detergent combined with large tidal volume ventilation on alveolocapillary permeability

1996 • 8 citations

Ventilatory Management of ALI/ARDS

2006 • 8 citations