Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

MicroRNAs

2004 • 33,206 citations

MicroRNA expression profiles classify human cancers

2005 • 9,457 citations

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

2008 • 8,256 citations

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

2008 • 3,700 citations

Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection

2000 • 3,126 citations

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

2007 • 2,995 citations

Java Treeview—extensible visualization of microarray data

2004 • 2,963 citations

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

2005 • 2,369 citations

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

2008 • 2,188 citations

Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer

2005 • 2,139 citations

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

2003 • 1,967 citations

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

2001 • 1,824 citations

Molecular requirements for epithelial–mesenchymal transition during tumor progression

2005 • 1,799 citations

A reciprocal repression between ZEB1 and members of the miR‐200 family promotes EMT and invasion in cancer cells

2008 • 1,665 citations

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2

2008 • 1,567 citations

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

2008 • 1,555 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Molecular Definition of Breast Tumor Heterogeneity

2007 • 1,338 citations

Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome

2004 • 1,249 citations

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

2001 • 1,145 citations

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

2008 • 1,036 citations

Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome

2004 • 1,016 citations

DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells

2005 • 771 citations

Regulatory element detection using correlation with expression

2001 • 746 citations

Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection

2000 • 699 citations

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

1991 • 659 citations

Cell-type-specific signatures of microRNAs on target mRNA expression

2006 • 650 citations

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

1998 • 625 citations

The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity

2007 • 586 citations

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

2001 • 582 citations

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

2001 • 559 citations

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

2003 • 550 citations

The Differential Effects of Mutant p53 Alleles on Advanced Murine Lung Cancer

2005 • 529 citations

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

2006 • 376 citations

The emerging role of miR-200 family of MicroRNAs in epithelial-mesenchymal transition and cancer metastasis

2008 • 354 citations

Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines

1992 • 298 citations

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer

2009 • 260 citations

Insulin-Like Growth Factor-I Activates Gene Transcription Programs Strongly Associated With Poor Breast Cancer Prognosis

2008 • 258 citations

K-ras activation generates an inflammatory response in lung tumors

2005 • 254 citations

High metastatic potential in mice inheriting a targeted p53 missense mutation

2000 • 197 citations

A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions

2008 • 153 citations

MicroRNAs in malignant progression

2008 • 128 citations

A genetic mouse model for metastatic lung cancer with gender differences in survival

2007 • 97 citations

Nonrandom structural and numerical chromosome changes in non‐small‐cell lung cancer

1991 • 95 citations

Phosphatidylinositol 3-Kinase Mediates Bronchioalveolar Stem Cell Expansion in Mouse Models of Oncogenic K-ras-Induced Lung Cancer

2008 • 81 citations

Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma

2009 • 81 citations

Atypical adenomatous hyperplasia and adenocarcinoma of the human lung: their heterology in form and analogy in immunohistochemical characteristics.

1996 • 54 citations

Atypical adenomatous hyperplasia and adenocarcinoma of the human lung: Their heterology in form and analogy in immunohistochemical characteristics

1996 • 42 citations

[Atypical adenomatous hyperplasia].

1994 • 18 citations