An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic
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References (33)
<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations
1983 • 14,615 citations
A small molecule–kinase interaction map for clinical kinase inhibitors
2005 • 1,854 citations
Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase
2000 • 1,770 citations
Tyrosine Kinase Inhibition: An Approach to Drug Development
1995 • 1,655 citations
Simulation of activation free energies in molecular systems
1996 • 1,279 citations
Quantum and statistical mechanical studies of liquids. 10. Transferable intermolecular potential functions for water, alcohols, and ethers. Application to liquid water
1981 • 1,210 citations
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
2006 • 1,156 citations
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
2006 • 1,126 citations
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
1995 • 929 citations
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications
2001 • 698 citations
Features of Selective Kinase Inhibitors
2005 • 625 citations
Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase
2004 • 598 citations
Issues and progress with protein kinase inhibitors for cancer treatment
2003 • 529 citations
Evidence for In Vivo Phosphorylation of the Grb2 SH2-Domain Binding Site on Focal Adhesion Kinase by Src-Family Protein-Tyrosine Kinases
1996 • 450 citations
Solvent effects on protein motion and protein effects on solvent motion
1989 • 409 citations
STRESS signaling pathways that modulate cardiac myocyte apoptosis
2004 • 334 citations
Inhibition of the ABL Kinase Activity Blocks the Proliferation of BCR/ABL+Leukemic Cells and Induces Apoptosis
1997 • 325 citations
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
1998 • 271 citations
Insufficiently dehydrated hydrogen bonds as determinants of protein interactions
2002 • 254 citations
Characterization of pp60c-src Tyrosine Kinase Activities Using a Continuous Assay: Autoactivation of the Enzyme Is an Intermolecular Autophosphorylation Process
1995 • 192 citations
The GIST of targeted cancer therapy: A tumor (Gastrointestinal stromal tumor), a mutated gene (c-kit), and a molecular inhibitor (STI571)
2002 • 145 citations
Pharmaceutical research in molecular oncology
1994 • 134 citations
The c-kit tyrosine kinase inhibitor STI571 for colorectal cancer therapy.
2002 • 133 citations
TYROSINE KINASE INHIBITORS AND THE DAWN OF MOLECULAR CANCER THERAPEUTICS
2004 • 118 citations
Chronic myelogenous leukemia as a paradigm of early cancer and possible curative strategies
2003 • 114 citations
Molecular Remissions Induced by Liposomal-Encapsulated All-Trans Retinoic Acid in Newly Diagnosed Acute Promyelocytic Leukemia
1999 • 106 citations
Imatinib does not induce cardiac left ventricular failure in gastrointestinal stromal tumours patients: Analyis of EORTC-ISG-AGITG study 62005
2007 • 100 citations
Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase
2001 • 90 citations
Contractile activity modulates myosin heavy chain-beta expression in neonatal rat heart cells
1991 • 72 citations
Molecularly Targeted Therapy: Have the Floodgates Opened?
2004 • 55 citations
A new model of congestive heart failure in the mouse due to chronic volume overload
2001 • 52 citations
Molecular basis for specificity in the druggable kinome: sequence-based analysis
2007 • 47 citations
Establishment of a mouse gastrointestinal stromal tumour model and evaluation of response to imatinib by small animal positron emission tomography.
2006 • 40 citations