Mendelian randomization: prospects, potentials, and limitations

Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies

2002 • 9,810 citations

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1995 • 7,378 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

2003 • 4,975 citations

Blood pressure, stroke, and coronary heart disease

1990 • 4,424 citations

Blood pressure, stroke, and coronary heart disease *1Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias

1990 • 4,310 citations

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease

1997 • 4,137 citations

Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

1992 • 3,145 citations

Prevention of neural tube defects: Results of the Medical Research Council vitamin study

1992 • 2,294 citations

Homocysteine and Risk of Ischemic Heart Disease and Stroke

2002 • 2,000 citations

Limitations of the Application of Fourfold Table Analysis to Hospital Data

1946 • 1,783 citations

The proof and measurement of association between two things

2010 • 1,584 citations

Alcohol Consumption and Mortality among Middle-Aged and Elderly U.S. Adults

1997 • 1,341 citations

Problems of reporting genetic associations with complex outcomes

2003 • 1,221 citations

Molecular genetics of the LDL receptor gene in familial hypercholesterolemia

1992 • 1,142 citations

Genetic associations with human longevity at the APOE and ACE loci

1994 • 1,079 citations

5, 10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review

2000 • 1,041 citations

MTHFR 677C→T Polymorphism and Risk of Coronary Heart Disease

2002 • 934 citations

Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study

2000 • 771 citations

Colorectal cancer risk, chronic illnesses, operations and medications: case control results from the Melbourne Colorectal Cancer Study

2007 • 642 citations

BACTERIA AND qTIOLOGY OF CANCER OF LARGE BOWEL

1971 • 641 citations

Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100.

1989 • 633 citations

RISKS OF ISCHÆMIC HEART-DISEASE IN FAMILIAL HYPERLIPOPROTEINÆMIC STATES

1969 • 623 citations

Mutations in the glucokinase gene of the fetus result in reduced birth weight

1998 • 602 citations

Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes.

1986 • 527 citations

Epidemiological methods for studying genes and environmental factors in complex diseases

2001 • 473 citations

Tuberculosis and Chronic Hepatitis B Virus Infection in Africans and Variation in the Vitamin D Receptor Gene

1999 • 443 citations

Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease.

1992 • 389 citations

Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).

1997 • 361 citations

Stroke and Alcohol Consumption

1986 • 336 citations

Molecular Epidemiology of Vitamin D Receptor Gene Variants

2000 • 319 citations

The Effect of Cessation and Resumption of Moderate Alcohol Intake on Serum High-Density-Lipoprotein Subfractions

1984 • 308 citations

Exploiting the Vascular Protective Effects of High-Density Lipoprotein and its Apolipoproteins

2001 • 304 citations

Genetic Variation in Alcohol Dehydrogenase and the Beneficial Effect of Moderate Alcohol Consumption on Myocardial Infarction

2001 • 298 citations

Vitamin D Receptor (VDR) mRNA and VDR Protein Levels in Relation to Vitamin D Status, Insulin Secretory Capacity, and VDR Genotype in Bangladeshi Asians

2002 • 284 citations

How independent are “independent” effects? relative risk estimation when correlated exposures are measured imprecisely

1991 • 277 citations

Acetaldehyde Metabolism in Different Aldehyde Dehydrogenase‐2 Genotypes

1991 • 276 citations

Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottish men with 21 years of follow up

1999 • 273 citations

Childhood social circumstances and psychosocial and behavioural factors as determinants of plasma fibrinogen

1996 • 270 citations

APOE genotype as a risk factor for ischemic cerebrovascular disease

1999 • 269 citations

Cholesterol and Alzheimer’s disease

2001 • 258 citations

Familial defective apolipoprotein B-100: a review, including some comparisons with familial hypercholesterolaemia

1993 • 230 citations

Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma

2002 • 229 citations

Ultraviolet radiation and autoimmune disease: insights from epidemiological research

2002 • 226 citations

Association of Mutations in the Apolipoprotein B Gene with Hypercholesterolemia and the Risk of Ischemic Heart Disease

1998 • 194 citations

Alcohol consumption—A risk factor for hemorrhagic and non-hemorrhagic stroke

1991 • 193 citations

Milk, coronary heart disease and mortality

2001 • 182 citations

Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese

1999 • 180 citations

Apolipoprotein E Alleles, Dyslipidemia,and Coronary Heart Disease

2001 • 170 citations

Genetic Predisposition for Adult Lactose Intolerance and Relation to Diet, Bone Density, and Bone Fractures

2004 • 166 citations

Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients.

1994 • 165 citations

Genetic Polymorphisms of Alcohol and Aldehyde Dehydrogenases and Risk for Esophageal and Head and Neck Cancers

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A possible link between vitamin d deficiency and impaired host defence to mycobacterium tuberculosis

1985 • 152 citations

Osteoporosis, Intestinal Lactase Deficiency and Low Dietary Calcium Intake

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Familial defective apolipoprotein B-100: a single mutation that causes hypercholesterolemia and premature coronary artery disease

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Serum concentrations of vitamin D metabolites in untreated tuberculosis.

1985 • 147 citations

Apolipoprotein E4: an allele associated with many diseases

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Helicobacter pylori infection and early onset myocardial infarction: case-control and sibling pairs study

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Aldehyde Dehydrogenase 2 Gene Is a Risk Factor for Myocardial Infarction in Japanese Men.

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Lactase Deficiency: Prevalence in Osteoporosis

1978 • 142 citations

Alcohol, cardiovascular risk factors and mortality: the Chicago experience.

1981 • 139 citations

Faecal unconjugated bile acids in patients with colorectal cancer or polyps.

1992 • 137 citations

Seasonality of tuberculosis: the reverse of other respiratory diseases in the UK.

1996 • 135 citations

Aspirin and nonsteroidal anti-inflammatory agents and risk for colorectal adenomas

1998 • 126 citations

How the gut senses its content

2002 • 126 citations

The Role of Vitamin D in Tuberculosis

1988 • 125 citations

Spectrum of LDL receptor gene mutations in heterozygous familial hypercholesterolemia

1997 • 116 citations

Vitamin D Receptor Gene Polymorphism Affects Onset Pattern of Type 1 Diabetes

2003 • 111 citations

ALCOHOL, CORONARY DISEASE, AND HYPERTENSION

1996 • 108 citations

Incubation period of coronary heart disease.

1982 • 107 citations

Metabolic epidemiology of colorectal cancer.

1987 • 107 citations

A study of vitamin d levels in indonesian patients with untreated pulmonary tuberculosis

1985 • 107 citations

The role of vitamin D receptor gene polymorphisms in bone biology

2002 • 91 citations

Does lactose intolerance predispose to low bone density? A population-based study of perimenopausal finnish women

1996 • 87 citations

Confounding, ascertainment bias, and the blind quest for a genetic ‘fountain of youth’

2003 • 83 citations

Vegetarian diet as a risk factor for tuberculosis in immigrant south London Asians.

1995 • 80 citations

Increased prevalence of lactose malabsorption in Crohn's disease patients at low risk for lactose malabsorption based on ethnic origin.

1997 • 76 citations

Maternal diabetes alters birth weight in glucokinase-deficient (MODY2) kindred but has no influence on adult weight, height, insulin secretion or insulin sensitivity

2000 • 74 citations

Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.

2002 • 72 citations

Alcohol and hypertension: epidemiologic and experimental considerations. The Lipid Research Clinics Program.

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Bile acid concentrations, cytotoxicity, and pH of fecal water from patients with colorectal adenomas.

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Cholesterol and coronary heart disease: screening and treatment

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Are we really dying for a tan?

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Hypothesis Is Lactose a Dietary Risk Factor for Ischaemic Heart Disease?

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Plasma fibrinogen and fibrinogen genotypes in 4685 cases of myocardial infarction and in 6002 controls: Test of causality by "Mendelian randomisation"

2000 • 60 citations

Alcohol and high-density-lipoprotein cholesterol:a randomized controlled trial

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The C/C_₁₃₉₁₀ and G/G_₂₂₀₁₈ Genotypes for Adult-type Hypolactasia are not Associated with Inflammatory Bowel Disease

2003 • 56 citations

Genetic epidemiological studies of coronary heart disease

2002 • 56 citations

Apolipoprotein E gene polymorphism and colorectal cancer: gender-specific modulation of risk and prognosis

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Fibrinogen, C-reactive protein and coronary heart disease: does Mendelian randomization suggest the associations are non-causal?

2004 • 55 citations

Fecal bile acid excretion pattern in colonic cancer patients

1985 • 46 citations

Triglyceride as a risk factor for ischaemic heart disease in British men: effect of adjusting for measurement error

1999 • 42 citations

An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomas.

2001 • 33 citations

Commentary: Reflections on alcohol and coronary heart disease

2001 • 30 citations

Inflammatory bowel disease: dogmas and heresies

2002 • 26 citations

Commentary: Could abstinence from alcohol be hazardous to your health?

2001 • 22 citations

Commentary: Alcohol, coronary heart disease and public health: which evidence-based policy

2001 • 22 citations

Coronary artery disease : genes, drugs, and the agricultural connection

2003 • 21 citations

Lactose absorption and milk drinking habits in Estonians with myocardial infarction

1988 • 11 citations

Commentary: Alcohol and coronary heart disease—laying the foundation for future work

2001 • 11 citations