Kinin Formation: Mechanisms and Role in Inflammatory Disorders

Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies

1966 • 4,504 citations

The Partial Thromboplastin Time with Kaolin: A Simple Screening Test for First Stage Plasma Clotting Factor Deficiencies

1961 • 1,015 citations

Competitive antagonists of bradykinin

1985 • 463 citations

Peptide Leukotriene Release after Antigen Challenge in Patients Sensitive to Ragweed

1984 • 396 citations

A PREALBUMIN ACTIVATOR OF PREKALLIKREIN

1971 • 349 citations

ACTIVATION OF HAGEMAN FACTOR IN SOLID AND FLUID PHASES

1973 • 346 citations

Identification and Some Properties of a New Fast‐Reacting Plasmin Inhibitor in Human Plasma

1976 • 341 citations

Kinins are generated in vivo following nasal airway challenge of allergic individuals with allergen.

1983 • 327 citations

Williams trait. Human kininogen deficiency with diminished levels of plasminogen proactivator and prekallikrein associated with abnormalities of the Hageman factor-dependent pathways.

1975 • 324 citations

ALTERED URINARY KALLIKREIN EXCRETION IN HUMAN HYPERTENSION

1971 • 304 citations

Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides

1983 • 295 citations

The primary inhibitor of plasmin in human plasma

1976 • 274 citations

Kallikreins (kininogenases)--a group of serine proteases with bioregulatory actions.

1979 • 267 citations

The coagulation-kinin pathway of human plasma

1987 • 263 citations

Pharmacology of kinins: Their relevance to tissue injury and inflammation

1983 • 256 citations

Human high molecular weight kininogen. Studies of structure-function relationships and of proteolysis of the molecule occurring during contact activation of plasma.

1979 • 230 citations

Autoactivation of human Hageman factor. Demonstration utilizing a synthetic substrate.

1980 • 229 citations

Isolation of a human cDNA for .alpha.2-thiol proteinase inhibitor and its identity with low molecular weight kininogen

1984 • 225 citations

Inhibition of activated Hageman factor and activated plasma thromboplastin antecedent by purified serum C1 inactivator.

1970 • 224 citations

Evidence for a New Plasma Thromboplastin Factor I. Case Report, Coagulation Studies and Physicochemical Properties

1965 • 221 citations

Interaction of Plasma Kallikrein with the C1̄ Inhibitor

1970 • 219 citations

Contribution of Plasma Protease Inhibitors to the Inactivation of Kallikrein in Plasma

1982 • 218 citations

THE FIRST COMPONENT OF THE KININ-FORMING SYSTEM IN HUMAN AND RABBIT PLASMA

1971 • 216 citations

Urinary Kallikrein Excretion in Normal Man

1974 • 212 citations

STUDIES ON THE ACTION OF HAGEMAN FACTOR: EVIDENCE THAT ACTIVATED HAGEMAN FACTOR IN TURN ACTIVATES PLASMA THROMBOPLASTIN ANTECEDENT*

1961 • 210 citations

Processing of Apolipoprotein B-100 of Human Plasma Low Density Lipoproteins by Tissue and Plasma Kallikreins

1986 • 201 citations

Mechanisms of activation of the classical pathway of complement by Hageman factor fragment.

1983 • 196 citations

Flaujeac trait. Deficiency of human plasma kininogen.

1975 • 193 citations

Role of hageman factor in the initiation of clotting by glass

1958 • 188 citations

Human urinary kallikrein converts inactive to active renin and is a possible physiological activator of renin

1978 • 187 citations

Interaction between hyperosmolar and IgE-mediated histamine release from basophils and mast cells.

1984 • 187 citations

KININS STIMULATE NET CHLORIDE SECRETION BY THE RAT COLON

1982 • 177 citations

PREKALLIKREIN DEFICIENCY IN MAN

1973 • 175 citations

Kinetics of activation and autoactivation of human factor XII

1984 • 166 citations

A single gene for bovine high molecular weight and low molecular weight kininogens

1983 • 164 citations

Inactivation of kallikrein in human plasma.

1983 • 161 citations

Surface and fluid phase activities of two forms of activated Hageman factor produced during contact activation of plasma.

1978 • 161 citations

In vitro activation of the contact (Hageman factor) system of plasma by heparin and chondroitin sulfate E

1984 • 160 citations

Nucleotide sequence of cloned cDNA for human pancreatic kallikrein

1985 • 146 citations

De novo formation of vascular receptors for bradykinin

1978 • 137 citations

Detection of active kallikrein in induced blister fluids of hereditary angioedema patients.

1980 • 135 citations

RAT SUBMANDIBULAR GLAND KALLIKREINS: PURIFICATION AND CELLULAR LOCALIZATION

1976 • 133 citations

A sensitive radioimmunoassay method for urinary kinins in man.

1978 • 129 citations

Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen and its light chain.

1979 • 126 citations

A radioimmunoassay for bradykinin in plasma and synovial fluid.

1969 • 123 citations

Human plasma kininogens are identical with α‐cysteine proteinase inhibitors

1985 • 123 citations

Inactivation of human high molecular weight kininogen by human mast cell tryptase.

1983 • 119 citations

Sulfatide-dependent autoactivation of human blood coagulation Factor XII (Hageman Factor).

1983 • 119 citations

Specific aldosterone binding in rat kidney and parotid

1972 • 118 citations

Airway response to carbachol in normal and asthmatic subjects: distinction between bronchial sensitivity and reactivity.

1977 • 117 citations

Comparative studies of human basophils and mast cells.

1983 • 112 citations

Defective Activation of Clotting, Fibrinolytic, and Permeability-Enhancing Systems in Human Fletcher Trait Plasma

1974 • 104 citations

Isolation and functional properties of the heavy and light chains of human plasma kallikrein.

1982 • 98 citations

THE INFLAMMATORY PROCESS IN ACUTE GOUTY ARTHRITIS. I. ACTIVATION OF HAGEMAN FACTOR BY SODIUM URATE CRYSTALS.

1965 • 98 citations

[49] Calcium-activated proteases in mammalian tissues

1981 • 96 citations

The relationship of structure and function in human Hageman factor. The association of enzymatic and binding activities with separate regions of the molecule.

1976 • 92 citations

Inhibitors of Kallikrein in Human Plasma

1972 • 91 citations

Human Kidney Kallikrein: cDNA Cloning and Sequence Analysis

1985 • 90 citations

Studies on Human High Molecular Weight (HMW) Kininogen. II. Structural Change of HMW Kininogen by the Action of Human Plasma Kallikrein1

1981 • 90 citations

α2-PLASMIN-INHIBITOR DEFICIENCY (MIYASATO DISEASE)

1978 • 88 citations

The autoactivation of rabbit hageman factor

1979 • 87 citations

Concentrations of glandular kallikrein in human nasal secretions increase during experimentally induced allergic rhinitis.

1986 • 87 citations

Human urinary and plasma kinins: relationship to sodium-retaining steroids and plasma renin activity.

1979 • 86 citations

Enzymatic activities of activated and zymogen forms of human Hageman factor (factor XII)

1982 • 85 citations

Interaction of Plasma Kinins and Granulocytes

1967 • 81 citations

Studies of the digestion of bradykin, lys-bradykinin, and des-Arg9-bradykinin by angiotensin converting enzyme

1986 • 81 citations

Immunochemical studies of human high molecular weight kininogen and of its complexes with plasma prekallikrein or kallikrein.

1980 • 81 citations

Studies on Human Kininogens

1979 • 80 citations

Regulation of Salivary Kallikrein Secretion in the Rat Submandibular Gland

1977 • 80 citations

Mechanism of activation of bovine factor XI by factor XII and factor XIIa

1980 • 75 citations

Kinin metabolism in human nasal secretions during experimentally induced allergic rhinitis.

1987 • 72 citations

The Effect of Inhalations of Bradykinin on Healthy and Atopic (Asthmatic) Children

1968 • 69 citations

Preparation, Characterization, and Activation of a Highly Purified Factor XI: Evidence that a Hitherto Unrecognized Plasma Activity Participates in the Interaction of Factors XI and XII

1974 • 68 citations

Characterization and origin of immunoreactive glandular kallikrein in rat plasma

1981 • 67 citations

Endotoxin-Induced Kinin Production in Man

1972 • 67 citations

A human lung mast cell chymotrypsin-like enzyme. Identification and partial characterization.

1986 • 65 citations

Plasma Inhibitors of the Components of the Fibrinolytic Pathway in Man

1973 • 65 citations

Immunoreactive glandular kallikrein in rat plasma: a radioimmunoassay for its determination

1982 • 63 citations

Kinin system responses in sepsis after trauma in man

1974 • 63 citations

Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases.

1982 • 63 citations

Demonstration of Inhibition of Mediator Release From Human Mast Cells by Azatadine Base

1986 • 62 citations

Autoactivatability of human Hageman factor (factor XII)

1980 • 62 citations

Plasmin inhibitor interactions. The effectiveness of alpha2-plasmin inhibitor in the presence of alpha2-macroglobulin.

1977 • 61 citations

Assay of prekallikrein in human plasma: comparison of amidolytic, esterolytic, coagulation, and immunochemical assays

1982 • 59 citations

Generation of kinin-like agents by chondroitin sulfate, heparin, chitin sulfate, and human articular cartilage: possible pathophysiologic implications.

1970 • 59 citations

Immunological studies of prekallikrein, kallikrein, and high-molecular-weight kininogen in normal and deficient plasmas and in normal plasma after cold-dependent activation.

1980 • 58 citations

Kallikrein activation of a high molecular weight atrial peptide

1984 • 57 citations

Kallikrein-Bradykinin System in Chronic Alcoholic Liver Disease

1972 • 52 citations

Immunoglobulin E-mediated release of a kininogenase from purified human lung mast cells.

1985 • 49 citations

A Major Sex Difference in Kallikrein-Like Activity in the Rat Anterior Pituitary*

1984 • 46 citations

Immunolocalization of the protease kallikrein in the colon.

1983 • 44 citations

Dissemination of contact activation in plasma by plasma kallikrein.

1980 • 43 citations

Tissue kallikrein synthesis and its modification by testosterone or low dietary sodium

1984 • 43 citations

Kallikreins in Glandular Tissues

1970 • 39 citations

Activation of Inactive Plasma Renin by Tissue Kallikreins*

1979 • 37 citations

The effect of cations on the activity of human urinary kallikrein.

1982 • 36 citations

Urate crystal--dependent cleavage of Hageman factor in human plasma and synovial fluid.

1980 • 36 citations

The Kinin System of Human Plasma VI. The Action of Plasmin

1971 • 33 citations

Autonomic nerve stimulation, kallikrein content anc acinar cell granules of the cat's submandibular gland.

1975 • 33 citations

Human plasma kallikrein and C1 inhibitor form a complex possessing an epitope that is not detectable on the parent molecules: demonstration using a monoclonal antibody.

1985 • 30 citations

Inhibitory effects of sodium and other monovalent cations on purified versus membrane-bound kallikrein.

1983 • 29 citations

Activation of hageman factor in the nephrotic syndrome

1974 • 29 citations

Immunoreactive tissue kallikrein in human serum.

1984 • 29 citations

Kallikrein-kinin system in regulation of submandibular gland blood flow

1982 • 28 citations

Effects of Alterations in Sodium and Water Metabolism on Urinary Excretion of Active and Inactive Kallikrein in Man*

1983 • 27 citations

C1s-induced vascular permeability in C2-deficient guinea pigs.

1986 • 26 citations

Immunohistochemical localization of glandular kallikrein in the endocrine and exocrine human pancreas.

1983 • 25 citations

Atrial natriuretic factor and urinary kallikrein in the rat: antagonistic factors?

1984 • 24 citations

Isolation of prokallikrein from human urine.

1979 • 24 citations

Endotoxin-induced kinin (bradykinin) formation: Activation of Hageman factor and plasma kallikrein in human plasma

1970 • 21 citations

Development of a radioimmunoassay for [des-Arg9]-bradykinin

1983 • 20 citations

Effects of restriction of sodium or administration of fludrocortisone on parotid salivary kallikrein in man.

1982 • 19 citations

Localization of Kallikrein in Porcine Pancreas and Submandibular Gland as Revealed by the Indirect Immunofluorescence Technique

1978 • 18 citations

Rapid purification of a prekallikrein from rat pancreas

1981 • 18 citations

Effects of different tissue processing methods on the immunohistochemical localization of kallikrein in the pancreas.

1981 • 17 citations

Purification and characterization of multiple forms of human plasma prekallikrein.

1985 • 17 citations

Active site of bovine factor XI (plasma thromboplastin antecedent)

1977 • 16 citations

Activation of Hageman factor by proteases released during antigen challenge of human lung.

1981 • 13 citations

The kinin system in allergic states.

1972 • 13 citations

Homogeneity and multiplicity forms of glandular kallikreins.

1975 • 9 citations

The IgE-dependent release of a Hageman factor cleaving factor from human lung.

1986 • 8 citations

Surface Adsorption of Factor XI: Association of Adsorption Sites with the Heavy Chain of Activated Factor XI

1980 • 8 citations

The Role of Kinins in Human Allergic Disease

1986 • 7 citations