The use of computers to study rates of lipid metabolism

Applied analysis

1961 • 1,590 citations

Proceedings of the 6th Berkeley Symposium on Mathematical Statistics and Probability

1972 • 1,365 citations

Carbon tetrachloride hepatotoxicity.

1967 • 980 citations

ON THE CALCULATION OF "TURNOVER TIME" AND "TURNOVER RATE" FROM EXPERIMENTS INVOLVING THE USE OF LABELING AGENTS

1943 • 538 citations

The Metabolism of Albumin Bound C14-Labeled Unesterified Fatty Acids in Normal Human Subjects

1958 • 353 citations

Formation and fate of endogenous triglycerides in blood plasma of rabbits

1962 • 340 citations

The design and analysis of isotope experiments

1960 • 325 citations

Basic Principles of the Tracer Method.

1963 • 316 citations

Regulation of plasma free fatty acid turnover

1961 • 306 citations

The metabolism of adipose tissue in vitro

1961 • 274 citations

THE METABOLISM OF CHYLOMICRA. I. THE REMOVAL OF PALMITIC ACID-1-C14 LABELED CHYLOMICRA FROM DOG PLASMA

1956 • 249 citations

Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver

1967 • 243 citations

Validation of an incompletely coupled two-compartment nonrecycling catenary model for turnover of liver and plasma triglyceride in man

1965 • 195 citations

Recycling of Intravenously Injected Palmitic Acid‐l‐C¹⁴ as Esterified Fatty Acid in the Plasma of Rats and Turnover Rate of Plasma Triglycerides

1960 • 189 citations

The role of the liver and of extrahepatic tissues in the transport and metabolism of fatty acids and triglycerides in the dog

1961 • 186 citations

Theory and Use of Tracers in Determining Transfer Rates in Biological Systems

1957 • 183 citations

Some Formal Approaches to the Analysis of Kinetic Data in Terms of Linear Compartmental Systems

1962 • 169 citations

THE INCORPORATION OF PLASMA FREE FATTY ACIDS INTO PLASMA TRIGLYCERIDES IN MAN*

1961 • 165 citations

Use of multicompartmental models to measure rates of triglyceride metabolism in rats

1964 • 158 citations

THE FORMULATION AND TESTING OF MODELS

1963 • 127 citations

Computers in Biomedical Research

1966 • 123 citations

TURNOVER AND OXIDATION OF BODY GLUCOSE IN NORMAL AND ALLOXAN-DIABETIC RATS

1950 • 122 citations

Effect of carbon tetrachloride on hepatic synthesis and release of triglycerides

1962 • 121 citations

Uptake and Release of Cholesterol by Rabbit Atheromatous Lesions

1966 • 100 citations

Nomenclature for Tracer Kinetics

1968 • 98 citations

Plasma and Liver Lipids of Ethionine‐Treated Rāts

1962 • 97 citations

Complete solution of the three-compartment model in steady state after single injection of radioactive tracer

1959 • 97 citations

C¹⁴ studies in carbohydrate metabolism: glucose pool size and rate of turnover in the normal rat

1959 • 94 citations

Lipid release by liver slices

1961 • 83 citations

C14 STUDIES IN CARBOHYDRATE METABOLISM

1954 • 81 citations

REVERSAL BY ADENINE OF THE ETHIONINE-INDUCED LIPID ACCUMULATION IN THE ENDOPLASMIC RETICULUM OF THE RAT LIVER

1965 • 77 citations

Handbook of Physiology, Section 5: Adipose Tissue.

1966 • 72 citations

Rates of Reactions Involved in Phosphatide Synthesis in Liver and Small Intestine of Intact Rats

1965 • 72 citations

Mechanisms for removal of chyle triglyceride from the circulating blood as studied with [14C]glycerol and [3H]palmitic acid-labeled chyle

1965 • 68 citations

Lack of Uptake and Oxidation of Chylomicron Triglyceride to Carbon Dioxide and Ketone Bodies by the Perfused Rat Liver

1965 • 66 citations

Quantitative aspects of free fatty acid metabolism in the fasted rat

1967 • 63 citations

STUDIES OF IODOALBUMIN METABOLISM. I. A MATHEMATICAL APPROACH TO THE KINETICS*

1959 • 62 citations

Rate of glucose transformation in the rat by whole-body analysis after blucose-14-C

1967 • 61 citations

THE METABOLISM OF VARIOUSLY C14-LABELED GLUCOSE IN MAN AND AN ESTIMATION OF THE EXTENT OF GLUCOSE METABOLISM BY THE HEXOSE MONOPHOSPHATE PATHWAY

1961 • 59 citations

Movement of Labeled Cholesterol Between Plasma Lipoprotein and Normal Arterial Wall across the Intimal Surface

1966 • 59 citations

Acute Effects of Nicotinic Acid in the Rat

1966 • 57 citations

Compartments, pools and spaces in medical physiology

1968 • 56 citations

Hepatic triglyceride secretion in relation to lipogenesis and free fatty acid mobilization in fasted and glucose-refed rats

1968 • 50 citations

Kinetic analysis of the oxidation of palmitate-1-14C in man during prolonged heavy muscular exercise

1967 • 49 citations

The origin and glyceride distribution of fatty acids in rat adipose tissue.

1966 • 42 citations

Effect of carbon tetrachloride ingestion on liver and plasma triglyceride turnover rates

1964 • 42 citations

OXIDATION OF GLUCOSE LABELED WITH RADIOACTIVE CARBON BY NORMAL AND ALLOXAN-DIABETIC RATS

1948 • 39 citations

The role of the liver in the uptake of plasma and chyle triglycerides in the rat

1966 • 38 citations

RESOLUTION OF MULTI‐COMPONENT EXPONENTIAL DECAY CURVES USING FOURIER TRANSFORMS

1963 • 37 citations

Plasma glucose and free fatty acid metabolism in normal and long-fasted dogs

1968 • 36 citations

Effect of glucose feeding on net transport of plasma free fatty acids

1969 • 36 citations

The Application of Multicompartmental Analysis to Problems of Clinical Medicine

1968 • 35 citations

Endogenous triglyceride turnover in liver and plasma of the dog

1967 • 35 citations

Turnover of lactic acid in normal and diabetic dogs calculated by two tracer methods

1967 • 32 citations

C¹⁴ studies in carbohydrate metabolism: V. Glucose metabolism in alloxan-diabetic rats

1961 • 32 citations

A mathematical model for copper metabolism and its relation to Wilson's disease

1966 • 32 citations

Determination of Rates of Glucose Oxidation in Normal and Diabetic Dogs by a Technique Involving Continuous Injection of C¹⁴-Glucose

1956 • 29 citations

C¹⁴ studies in carbohydrate metabolism. IV. Characteristics of bicarbonate pool system in the rat

1959 • 29 citations

ALTERATIONS IN TRIGLYCERIDE METABOLISM AS PRODUCED BY DIETARY CHANGE.

1964 • 23 citations

Phosphatide Exchange between Plasma and Organs

1939 • 21 citations

THE RATE OF DECARBOXYLATION OF MEVALONIC ACID‐l‐C¹⁴ IN MAN

1963 • 12 citations

The effect of anesthesia on the fate of injected free fatty acid

1966 • 12 citations

Changes in oxidative metabolism with glucose ingestion.

1966 • 10 citations

The Application of Mathematics to Biological Problems

1966 • 9 citations

Distribution of radioactive glycerol and fatty acids among adipose tissue triglycerides after administration of glucose-U-14C

1967 • 9 citations

A DIRECT ANALOG COMPUTER FOR MULTI‐COMPARTMENT SYSTEMS*

1963 • 6 citations

AN ANALOG COMPUTER FOR THE GENERALIZED MULTI‐COMPARTMENT MODEL OF TRANSPORT IN BIOLOGICAL SYSTEMS*

1963 • 6 citations

APPLICATION OF HYDRODYNAMIC ANALOGS AND DIGITAL COMPUTER TO THE STUDY OF PHOSPHOLIPID KINETICS*

1963 • 5 citations