Repeated 0.5-Gy Gamma Irradiation Attenuates Autoimmune Disease in MRL-lpr/lprMice with Suppression of CD3⁺CD4⁻CD8⁻B220⁺T-Cell Proliferation and with Up-regulation of CD4⁺CD25⁺Foxp3⁺Regulatory T Cells

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

2001 • 580 citations

Effective treatment of collagen‐induced arthritis by adoptive transfer of CD25+ regulatory T cells

2005 • 378 citations

The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery

2003 • 179 citations

Interaction of mutant lpr gene with background strain influences renal disease

1985 • 168 citations

Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma.

2005 • 165 citations

Age-associated increase in interleukin 6 in MRL/lpr mice

1991 • 164 citations

Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis.

1993 • 125 citations

Low Dose γ-Rays Activate Immune Functions via Induction of Glutathione and Delay Tumor Growth

2004 • 103 citations

Prolongation of Life Span Associated with Immunological Modification by Chronic Low-Dose-Rate Irradiation in MRL-lpr/lprMice

2004 • 87 citations

Two histopathologic types of inflammatory vascular disease in MRL/Mp autoimmune mice. Model for human vasculitis in connective tissue disease

1985 • 76 citations

Congenic autoimmune murine models of central nervous system diseas in connective tissue disorders

1983 • 75 citations

T cell derived IL-6 is differentially required for antigen-specific antibody secretion by primary and secondary B cells.

1989 • 73 citations

Nephritogenic Anti‐DNA antibodies regulate gene expression in MRL/lpr mouse glomerular mesangial cells

2006 • 71 citations

Radiosensitivity of T and B lymphocytes. IV. Effect of whole body irradiation upon various lymphoid tissues and numbers of recirculating lymphocytes.

1977 • 68 citations

T cell lineages in the thymus of lpr/lpr mice. Evidence for parallel pathways of normal and abnormal T cell development.

1987 • 66 citations

Prevention of Type I Diabetes by Low-Dose Gamma Irradiation in NOD Mice

2000 • 59 citations

The role of CD4+CD25+ T cells in autoantibody production in murine lupus

2006 • 58 citations

Ligand recognition by murine anti-DNA autoantibodies. II. Genetic analysis and pathogenicity.

1996 • 49 citations

Radiosensitivity of T and B Lymphocytes

1977 • 47 citations

The MRL-Ipr/Ipr Mouse. A Model for the Study of Rheumatoid Arthritis

1988 • 46 citations

Elevation of IL-6 in Transgenic Mice Results in Increased Levels of the 90kDa Heat Shock Protein (hsp90) and the Production of Anti-hsp90 Antibodies

1998 • 29 citations

Autoreactivity to collagen in a murine lupus model

1984 • 26 citations

Apoptosis of circulating lymphocytes induced by whole body gamma-irradiation and its mechanism.

1999 • 25 citations

Repeated 0.5-Gy γ-ray irradiation attenuates autoimmune manifestations in MRL-lpr/lprmice

2005 • 24 citations

Effect of pre-irradiation with low-dose gamma-rays on chemically induced hepatotoxicity and glutathione depletion.

2000 • 20 citations