THE ENTERIC NERVOUS SYSTEM AND REGULATION OF INTESTINAL MOTILITY

The Enteric Nervous System

2016 • 1,113 citations

The movements and innervation of the small intestine

1899 • 967 citations

The interdigestive myo‐electric complex of the stomach and small bowel of dogs.

1975 • 712 citations

A fluorescent indicator for measuring cytosolic free magnesium

1989 • 527 citations

Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach.

1996 • 518 citations

Role of nitric oxide in gastrointestinal and hepatic function and disease

1992 • 493 citations

Neurochemical classification of myenteric neurons in the guinea-pig ileum

1996 • 484 citations

c-kit-Dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract

1995 • 392 citations

Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity- induced expression of Fos immunoreactivity

1992 • 367 citations

Correlation between membrane potential, spike discharge and tension in smooth muscle

1955 • 361 citations

The peristaltic reflex: An analysis of the nerve pathways and their pharmacology

1976 • 303 citations

THE MOVEMENTS OF THE INTESTINES STUDIED BY MEANS OF THE RÖNTGEN RAYS

1902 • 280 citations

Jejunal Manometry Patterns in Health, Partial Intestinal Obstruction, and Pseudoobstruction

1983 • 232 citations

Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells

1994 • 232 citations

Identification and immunohistochemistry of cholinergic and non-cholinergic circular muscle motor neurons in the guinea-pig small intestine

1991 • 225 citations

Glutamatergic Enteric Neurons

1997 • 221 citations

Stretch-activated ion channels in smooth muscle: a mechanism for the initiation of stretch-induced contraction

1988 • 215 citations

Intracellular recording from myenteric neurons of the guinea‐pig ileum that respond to stretch

1998 • 209 citations

Plurichemical transmission and chemical coding of neurons in the digestive tract

1995 • 200 citations

Analysis of the responses of myenteric neurons in the small intestine to chemical stimulation of the mucosa

1997 • 199 citations

Identification of sensory nerve cells in a peripheral organ (the intestine) of a mammal

1995 • 195 citations

Electrophysiological characterization of myenteric neurons: how do classification schemes relate?

1994 • 192 citations

ATP mediates fast synaptic potentials in enteric neurons

1994 • 188 citations

Calbindin neurons of the guinea-pig small intestine: quantitative analysis of their numbers and projections

1990 • 169 citations

Localisation of NK1 receptor immunoreactivity to neurons and interstitial cells of the guinea-pig gastrointestinal tract

1996 • 167 citations

Control of the Interdigestive Myoelectric Activity in Dogs by the Vagus Nerves and Pentagastrin

1975 • 162 citations

Electrophysiology of guinea-pig myenteric neurons correlated with immunoreactivity for calcium binding proteins

1988 • 157 citations

Neurochemical coding of enteric neurons in the guinea pig stomach

1995 • 155 citations

Cellular sites of expression of the neurokinin‐1 receptor in the rat gastrointestinal tract

1995 • 155 citations

Two descending nerve pathways activated by distension of guinea‐pig small intestine.

1975 • 154 citations

The movements and innervation of the small intestine

1901 • 145 citations

Myoelectric Activity of the Autotransplanted Canine Jejunoileum

1981 • 140 citations

Motor and electric activity of the duodenum

1961 • 136 citations

Simultaneous intracellular recordings from enteric neurons reveal that myenteric ah neurons transmit via slow excitatory postsynaptic potentials

1993 • 133 citations

Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability

1996 • 133 citations

Distension-evoked ascending and descending reflexes in the circular muscle of guinea-pig ileum: an intracellular study

1990 • 130 citations

Identification of neurotransmitters regulating intestinal peristaltic reflex in humans

1989 • 129 citations

Intrinsic nervous control of migrating myoelectric complexes

1981 • 129 citations

Galanin-immunoreactive neurons in the guinea-pig small intestine: their projections and relationships to other enteric neurons

1987 • 127 citations

Neural reflexes controlling intestinal microcirculation

1996 • 123 citations

Synaptic responses evoked by mechanical stimulation of the mucosa in morphologically characterized myenteric neurons of the guinea-pig ileum

1991 • 123 citations

Identification of myenteric neurons which project to the mucosa of the guinea-pig small intestine

1991 • 121 citations

Immunohistochemical localization of 3',5'-cyclic guanosine monophosphate in the canine proximal colon: Responses to nitric oxide and electrical stimulation of enteric inhibitory neurons

1993 • 119 citations

Distinct distribution of CGRP-, enkephalin-, galanin-, neuromedin U-, neuropeptide Y-, somatostatin-, substance P-, VIP- and serotonin-containing neurons in the two submucosal ganglionic neural networks of the porcine small intestine

1990 • 119 citations

Distinct populations of sensory neurons mediate the peristaltic reflex elicited by muscle stretch and mucosal stimulation

1994 • 118 citations

All calbindin-immunoreactive myenteric neurons project to the mucosa of the guinea-pig small intestine

1994 • 118 citations

Ramifications of the axons of AH‐neurons injected with the intracellular marker biocytin in the myenteric plexus of the guinea pig small intestine

1991 • 114 citations

Some observations of the movements of the intestine before and after degenerative section of the mesenteric nerves

1905 • 114 citations

Immunohistochemical localisation of cholinergic markers in putative intrinsic primary afferent neurons of the guinea-pig small intestine

1998 • 114 citations

Reflex changes in circular muscle activity elicited by stroking the mucosa: an electrophysiological analysis in the isolated guinea-pig ileum

1988 • 112 citations

Ultrastructure and synaptic relationships of calbindin-reactive, Dogiel type II neurons, in myenteric ganglia of guinea-pig small intestine

1988 • 111 citations

Evidence that enteric motility reflexes can be initiated through entirely intrinsic mechanisms in the guinea‐pig small intestine

1995 • 110 citations

The involvement of intramural nerves in cholera toxin induced intestinal secretion

1983 • 109 citations

A pharmacological analysis of the neuronal circuitry involved in distension-evoked enteric excitatory reflex

1990 • 106 citations

Analysis of contributions of acetylcholine and tachykinins to neuro‐neuronal transmission in motility reflexes in the guinea‐pig ileum

1996 • 103 citations

Innervation of the intestinal muscular coat

1972 • 103 citations

Nitric oxide targets in the guinea-pig intestine identified by induction of cyclic GMP immunoreactivity

1993 • 100 citations

Vasodilatation of arterioles by acetylcholine released from single neurones in the guinea‐pig submucosal plexus.

1990 • 97 citations

ON THE INTESTINAL INTRINSIC REFLEXES

1958 • 96 citations

Purinergic fast excitatory postsynaptic potentials in myenteric neurons of guinea pig: Distribution and pharmacology

1997 • 95 citations

Long aboral projections of Dogiel type II, AH neurons within the myenteric plexus of the guinea pig small intestine

1995 • 93 citations

Roles of neuronal NK₁ and NK₃ receptors in synaptic transmission during motility reflexes in the guinea‐pig ileum

1998 • 93 citations

Excitatory synaptic potentials due to activation of neurons with short projections in the myenteric plexus

1984 • 90 citations

Total numbers of neurons in myenteric ganglia of the guinea-pig small intestine

1993 • 90 citations

Choline acetyltransferase immunoreactivity in the human small and large intestine

1996 • 90 citations

Effect of vagotomy on electrical activity of the small intestine of the dog

1975 • 85 citations

Migration of the myoelectric complex after interruption of the myenteric plexus: Intestinal transection and regeneration of enteric nerves in the guinea pig

1989 • 83 citations

Interactions between reflexes evoked by distension and mucosal stimulation: Electrophysiological studies of guinea-pig ileum

1991 • 80 citations

Quantitative ultrastructural analysis of enkephalin‐, substance P‐, and VIP‐immunoreactive nerve fibers in the circular muscle of the guinea pig small intestine

1988 • 78 citations

Ultrastructural examination of the targets of serotoninn immunoreactive descending interneurons in the guinea pig small intestine

1995 • 76 citations

Electrophysiological analysis of projections of enteric inhibitory motoneurones in the guinea‐pig small intestine.

1986 • 75 citations

Accommodation mediated by enteric inhibitory reflexes in the isolated guinea‐pig small intestine.

1994 • 72 citations

Ascending enteric reflex: multiple neurotransmitter systems and interactions

1989 • 72 citations

The relationship between gastrointestinal motility and secretion

1987 • 71 citations

The source of the nerve fibres forming the deep muscular and circular muscle plexuses in the small intestine of the guinea-pig

1987 • 71 citations

Regulation of colonic propulsion by enteric excitatory and inhibitory neurotransmitters

1996 • 71 citations

The role of ascending excitatory and descending inhibitory pathways in peristalsis in the isolated guinea‐pig small intestine.

1994 • 67 citations

Influence of the mucosa on the excitability of myenteric neurons

1997 • 65 citations

THE MOTOR ACTIVITIES OF THE STOMACH AND SMALL INTESTINE AFTER SPLANCHNIC AND VAGUS SECTION

1906 • 62 citations

The circuitry of the enteric nervous system

1994 • 60 citations

Tachykinins as transmitters of ascending contractile component of the peristaltic reflex

1989 • 60 citations

Electrical mapping of the projections of intrinsic primary afferent neurones to the mucosa of the guinea‐pig small intestine

1998 • 59 citations

Sources of inputs to longitudinal muscle motor neurons and ascending interneurons in the guinea-pig small intestine

1995 • 58 citations

Investigation of the role of 5‐HT₃ and 5‐HT₄ receptors in ascending and descending reflexes to the circular muscle of guinea‐pig small intestine

1994 • 56 citations

Inhibitory innervation of colonic smooth muscle cells and interstitial cells of Cajal

1990 • 55 citations

THE MOVEMENTS OF THE COLON OF RATS AND GUINEA PIGS

1968 • 54 citations

Viscoelastic properties of the contracting detrusor. II. Experimental approach

1991 • 54 citations

Pharmacological evidence that nitric oxide may be a retrograde messenger in the enteric nervous system

1995 • 54 citations

Appositions made by axons of descending interneurons in the guinea-pig small intestine, investigated by confocal microscopy

1997 • 53 citations

Mucosal stimulation evokes vasodilation in submucosal arterioles by neuronal and nonneuronal mechanisms

1993 • 52 citations

Distension-induced secretion in the rat colon: mediation by prostaglandins and submucosal neurons

1990 • 50 citations

Mucosal distortion by compression elicits polarized reflexes and enhances responses of the circular muscle to distension in the small intestine

1991 • 50 citations

Analysis of connections between nitric oxide synthase neurons in the myenteric plexus of the guinea-pig small intestine

1995 • 47 citations

Quantitative analysis of inputs to somatostatin-immunoreactive descending interneurons in the myenteric plexus of the guinea-pig small intestine

1998 • 40 citations

In vitro analysis of rat intestinal wall movements at rest and during propagated contraction: a new method

1997 • 40 citations

Vasoactive intestinal polypeptide: a transmitter in submucous neurons mediating secretion in guinea pig distal colon.

1994 • 40 citations

Origins of synaptic inputs to calretinin immunoreactive neurons in the guinea-pig small intestine

1993 • 39 citations

Cholinergic and noncholinergic submucosal neurons dilate arterioles in guinea pig colon

1991 • 39 citations

Electrophysiological mapping of fast excitatory synaptic inputs to morphologically and chemically characterized myenteric neurons of guinea-pig small intestine

1996 • 38 citations

Differential sensitivities of morphine and motilin to initiate migrating motor complex in isolated intestinal segments

1986 • 34 citations

THE PARTICIPATION OF ENTERIC INHIBITORY NERVES IN ACCOMMODATION OF THE INTESTINE TO DISTENSION

1977 • 32 citations

Innervation of intestinal arteries by axons with immunoreactivity for the vesicular acetylcholine transporter (VAChT)

1998 • 31 citations

Role of 5‐HT3 receptors in peristaltic reflex elicited by stroking the mucosa in the canine jejunum.

1993 • 29 citations

Effect of Total Sympathectomy and of Decentralization on Migrating Complexes in Dogs

1987 • 29 citations

Peristaltic Movement Evoked in Intestinal Tube Devoid of Mucosa and Submucosa.

1992 • 27 citations

Contraction and accommodation of guinea pig duodenum in vitro

1991 • 15 citations

EXPERIMENTAL BASIS FOR REALISTIC LARGE‐SCALE COMPUTER SIMULATION OF THE ENTERIC NERVOUS SYSTEM

1996 • 8 citations

Sources of inputs to longitudinal muscle motor neurons and ascending interneurons in the guinea-pig small intestine

1995 • 5 citations