Recombinant Fv immunotoxins and Fv fragments as novel agents for cancer therapy and diagnosis

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Making Antibodies by Phage Display Technology

1994 • 1,516 citations

Single-Chain Antigen-Binding Proteins

1988 • 1,450 citations

Man-made antibodies

1991 • 935 citations

A comparison of strategies to stabilize immunoglobulin Fv-fragments

1990 • 469 citations

Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli

1987 • 449 citations

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

1989 • 420 citations

RECOMBINANT TOXINS AS NOVEL THERAPEUTIC AGENTS

1992 • 325 citations

Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erbB-2 receptor.

1992 • 188 citations

Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas.

1991 • 140 citations

Engineering antibody Fv fragments for cancer detection and therapy: Bisulfide-stabilized Fv fragments

1996 • 138 citations

Immunotoxins against cancer

1994 • 123 citations

Recombinant RFB4 Immunotoxins Exhibit Potent Cytotoxic Activity for CD22-Bearing Cells and Tumors

1997 • 115 citations

Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment

1994 • 101 citations

Molecular and functional characterisation of a fusion protein suited for tumour specific prodrug activation

1992 • 100 citations

Summary and Perspectives

1996 • 84 citations

Development of a humanized disulfide-stabilized anti-p185HER2 Fv-beta-lactamase fusion protein for activation of a cephalosporin doxorubicin prodrug.

1995 • 76 citations

Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice.

1990 • 64 citations

Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment.

1994 • 56 citations

Immunotoxin Therapy for Cancer

1993 • 54 citations

Genetic construction, expression, and characterization of a single chain anti-carcinoma antibody fused to beta-lactamase.

1993 • 51 citations

Recombinant Toxins: New Therapeutic Agents for Cancer

1995 • 46 citations

Biodistribution of 18F- and 125I-labeled anti-Tac disulfide-stabilized Fv fragments in nude mice with interleukin 2 alpha receptor-positive tumor xenografts.

1995 • 43 citations

In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats.

1994 • 40 citations

Targeting cancer with radiolabeled antibodies

1995 • 38 citations

Prevention of immunotoxin-induced immunogenicity by coadministration with CTLA4Ig enhances antitumor efficacy.

1997 • 34 citations

Identification of epitopes on a mutant form of Pseudomonas exotoxin using serum from humans treated with Pseudomonas exotoxin containing immunotoxins

1997 • 28 citations

Status of radiolabeled monoclonal antibodies for diagnosis and therapy of cancer.

1996 • 27 citations

Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice

1996 • 26 citations

Anti‐Tac(Fab)‐PE40, a recombinant double‐chain immunotoxin which kills interleukin‐2‐receptor‐bearing cells and induces complete remission in an in vivo tumor model

1994 • 20 citations

Rapid and specific uptake of anti-Tac disulfide-stabilized Fv by interleukin-2 receptor-bearing tumors.

1995 • 17 citations

B3(Fab)-PE38M: a recombinant immunotoxin in which a mutant form of Pseudomonas exotoxin is fused to the Fab fragment of monoclonal antibody B3.

1994 • 17 citations

From the basic science of B cells to biological missiles at the bedside.

1994 • 16 citations