The essential action of propranolol in hypertension

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

Evidence for the existence of monoamine neurons in the central nervous system

1965 • 1,538 citations

Effect of Age and High Blood Pressure on Barorefiex Sensitivity in Man

1971 • 1,047 citations

Propranolol Inhibition of Renin Secretion

1972 • 729 citations

The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias

1968 • 562 citations

Treatment of Hypertension with Propranolol

1969 • 426 citations

Beta adrenergic blockade in hypertension

1972 • 425 citations

SELECTIVE BLOCKADE OF ADRENOCEPTIVE BETA RECEPTORS IN THE HEART

1968 • 415 citations

Use of Propranolol (Inderal) in Treatment of Hypertension

1964 • 407 citations

Blocking of inhibitory adrenergic receptors by a dichloro analog of isoproterenol.

1958 • 373 citations

Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs

1965 • 347 citations

The pharmacodynamics and metabolism of propranolol in man

1970 • 272 citations

Evidence for an α-sympathomimetic component in the effects of catapresan on vasomotor centres: Antagonism by piperoxane

1971 • 268 citations

Influence of First-Pass Effect on Availability of Drugs on Oral Administration

1971 • 264 citations

Antihypertensive action of propranolol

1973 • 256 citations

THE EFFECTS ON CARDIAC MUSCLE OF β‐RECEPTOR ANTAGONISTS IN RELATION TO THEIR ACTIVITY AS LOCAL ANAESTHETICS

1965 • 248 citations

Differentiated blockade of the chronotropic effects of various adrenergic stimuli in the cat heart

1972 • 246 citations

The Effect of Chronic Adrenergic Receptor Blockade on Plasma Renin Activity in Man

1972 • 233 citations

The Disposition of Propranolol

1972 • 232 citations

Propranolol in hypertension: A study of long-term therapy, 1964–1970

1972 • 218 citations

The control of renin release

1973 • 210 citations

Pharmacokinetic studies on the selectiveβ 1-receptor antagonist metoprolol in man

1974 • 187 citations

Immediate Hemodynamic Effects of Beta-Adrenergic Blockade with Propranolol in Normotensive and Hypertensive Man

1968 • 180 citations

The central action of antihypertensive drugs, mediated via central α -receptors

1973 • 170 citations

Clinical pharmacology of beta‐receptor‐blocking drugs

1969 • 163 citations

Some effects of propranolol on the central nervous system

1965 • 159 citations

Pharmacological Properties of H 56/28—a ß‐Adrenergic Receptor Antagonist

1967 • 156 citations

Propranolol in hypertension

1966 • 147 citations

Cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 115)

1968 • 147 citations

Participation of Central Noradrenergic Neurons in Arterial Baroreceptor Reflexes in the Rabbit

1971 • 145 citations

Reduction in sympathetic nervous activity as a mechanism for hypotensive effect of propranolol

1975 • 142 citations

-Blockers and Plasma Renin Activity in Hypertension

1974 • 135 citations

Effect of alpha- and beta-Adrenergic Blocking Agents on the Renin Response to Hypoglycemia and Epinephrine in Dogs

1970 • 134 citations

Brain concentration of propranolol in relation to hypotensive effect in the rabbit with observations on brain propranolol levels in man.

1975 • 132 citations

Activation of the central pathway of the baroreceptor reflex, a possible mechanism of the hypotensive action of clonidine

1973 • 127 citations

Participation of Central Noradrenergic Neurons in Arterial Baroreceptor Reflexes in the Rabbit: A STUDY WITH INTRACISTERNALLY ADMINISTERED 6-HYDROXYDOPAMINE

1972 • 124 citations

CENTRAL α‐ AND β‐ADRENOCEPTORS MODIFYING ARTERIAL BLOOD PRESSURE AND HEART RATE IN CONSCIOUS CATS

1974 • 119 citations

Propranolol metabolism in man and dog: mass spectrometric identification of six new metabolites.

1972 • 119 citations

Pharmacokinetic Properties of the ??-Adrenergic Receptor Blocking Drugs

1974 • 116 citations

β-Adrenergic Blockade in Diuretic-Treated Patients with Essential Hypertension

1975 • 116 citations

Hypertensive and Renin-Suppressing Activities of Propranolol in Hypertensive Patients

1975 • 115 citations

Effect of Pronethalol in Angina Pectoris

1963 • 113 citations

HEMODYNAMIC EFFECTS OF ACUTE AND PROLONGED β‐ADRENERGIC BLOCKADE IN ESSENTIAL HYPERTENSION

1974 • 113 citations

Ineffectiveness of propranolol in hypertensive Jamaicans.

1968 • 108 citations

??-Adrenergic Receptor Blocking Drugs in Hypertension

1974 • 108 citations

Cardiovascular regulation by central adrenergic mechanisms and its alteration by hypotensive drugs.

1975 • 105 citations

Effects of Prolonged Treatment with Adrenergic β‐receptor Antagonists on Blood Pressure, Cardiovascular Design and Reactivity in Spontaneously Hypertensive Rats (SHR)

1974 • 104 citations

Central Hypotensive Activity of dl- and d-Propranolol

1970 • 103 citations

A comparison of beta adrenergic blocking drugs in the treatment of hypertension

1974 • 97 citations

Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline

1971 • 95 citations

PERITONEAL DIALYSIS IN MALARIA

1967 • 94 citations

Controlled Trial of Propranolol in Hypertension

1970 • 93 citations

Hypotensive action of propranolol

1966 • 89 citations

Autoradiographic Distribution Studies of Adrenergic Blocking Agents. II. ¹⁴C‐Propranolol, a β‐Receptor‐Type Blocker

1967 • 89 citations

Central and peripheral effects of propranolol and sotalol in normal human subjects

1972 • 86 citations

Beta‐adrenergic receptor blocking drugs, hypertension and plasma renin.

1975 • 84 citations

Cardiovascular effects of intracerebroventricular d-, l- and dl-propranolol in the conscious rabbit.

1974 • 81 citations

Propranolol therapy in essential hypertension

1972 • 76 citations

Effect of Propranolol on Elevated Arterial Blood Pressure

1968 • 75 citations

EFFECT OF PROPRANOLOL IN MILD HYPERTENSION

1966 • 72 citations

Dissociation between renin and arterial pressure responses to beta-adrenergic blockade in human essential hypertension.

1975 • 68 citations

THE USE OF PRINDOLOL (VISKEN) IN THE TREATMENT OF HYPERTENSION

1972 • 67 citations

Evaluation of practolol in hypertension. Effects on sympathetic nervous system and renin responsiveness.

1973 • 65 citations

Studies on the antihypertensive action of the optical isomers of propranolol in man

1974 • 63 citations

Individualization of Propranolol Therapy

1974 • 59 citations

Central cardiovascular effects of intracerebroventricular propranolol

1973 • 59 citations

PROPRANOLOL GIVEN TWICE DAILY IN HYPERTENSION

1973 • 57 citations

Release of noradrenaline from the hypothalamus in vivo

1970 • 57 citations

Effect of Propranolol on Blood Pressure and Plasma Renin Activity in the Spontaneously Hypertensive Rat

1974 • 56 citations

Carotid Sinus Participation in Experimental Renal Hypertension

1958 • 56 citations

Role of adrenergic neurone blockade in the hypotensive action of propranolol

1971 • 54 citations

Further similarities between the action of clonidine and a central activation of the depressor baroreceptor reflex

1974 • 54 citations

Hyperkinetic heart in severe hypertension: A separate clinical hemodynamic entity

1975 • 53 citations

Antihypertensive effects of practolol and sotalol

1974 • 52 citations

CARDIOVASCULAR EFFECTS OF ?-ADRENORECEPTOR BLOCKING AGENTS AFTER INTRACEREBROVENTRICULAR ADMINISTRATION IN CONSCIOUS NORMOTENSIVE CATS

1974 • 50 citations

Effects of Chronic Beta-Adrenergic Blockade on Systemic and Renal Haemodynamic Responses to Hyperosmotic Saline in Hypertensive Patients

1972 • 49 citations

The almost complete hepatic extraction of propranolol during intravenous administration in the dog

1971 • 49 citations

Trial of New Bronchodilator, Terbutaline, in Asthma

1971 • 48 citations

Modern trends in cardiology

1961 • 48 citations

A comparison of some cardiovascular properties of propranolol, MJ 1999 and quinidine in relation to their effects in hypertensive animals

1968 • 47 citations

Cardiovascular responses to carotid and vertebral artery infusions of propranolol

1971 • 45 citations

Propranolol therapy in essential hypertension. Observations on predictability of therapeutic response.

1974 • 43 citations

Haemodynamic effects of practolol.

1972 • 41 citations

CNS effects of propranolol in man

1973 • 39 citations

A comparison of timolol and propranolol in essential hypertension

1975 • 37 citations

Contribution of the central nervous system to the action of several antihypertensive agents (methyldopa, hydralazine and guanethidine).

1972 • 37 citations

Comparative studies on central factors contributing to the hypotensive action of propranolol, alprenolol, and their enantiomers

1974 • 35 citations

Modern trends in cardiology

1962 • 35 citations

Effects of beta adrenergic blocking agents on plasma renin activity in the conscious rabbit.

1974 • 33 citations

Subcellular distribution and possible nature of the binding for 14C-dibenamine and 14C-propanolol in the CNS

1969 • 33 citations

DOUBLE‐BLIND COMPARISON OF TWO BETA‐BLOCKING DRUGS WITH PREVIOUS THERAPY IN THE TREATMENT OF HYPERTENSION

1974 • 32 citations

Comparative hemodynamic studies in man of adrenergic β₁‐receptor agents without (H 93/26 = metoprolol) or with (H 87/07) intrinsic sympathicomimetic activity

1975 • 32 citations

AN ANTIHYPERTENSIVE ACTION OF PROPRANOLOL IN DOCA/SALT-TREATED RATS

1974 • 30 citations

COMPARISON OF THE EFFECTS OF PROPRANOLOL AND ICI 66082 IN BLOCKING THE RENIN RELEASING EFFECT OF RENAL NERVE STIMULATION IN THE CAT

1974 • 29 citations

Differential effects of propranolol on heart rate and plasma renin activity in patients treated with minoxidil

1974 • 28 citations

On the pressor action of propranolol in the rat.

1969 • 28 citations

Effect of practolol on blood pressure and renin release in man

1974 • 28 citations

Reduced Cardiovascular Responsiveness to Hypothalamic Stimulation during Urethane and Amobarbital Anesthesia

1973 • 28 citations

THE EFFECTS OF INTRAVENTRICULAR 6‐HYDROXYDOPAMINE ON BODY TEMPERATURE AND ARTERIAL BLOOD PRESSURE IN CATS AND RABBITS

1974 • 25 citations

Blood Pressure and Vascular Design in Renal Hypertension in Rats after Prolonged Propranolol Treatment

1974 • 24 citations

[Use of propranolol in treatment of hypertension].

1972 • 23 citations

Pacing after myocardial infarction

1971 • 22 citations

Suicidal attempt with propranolol.

1973 • 22 citations

Influence of an adrenergicβ-receptor blocking agent on the effect of various hypotensive agents in the hypertensive rat

1965 • 21 citations

The possibility that noradrenaline is a sympatho-inhibitory transmitter in the spinal cord.

1972 • 21 citations

A technique for recording sympathetic nerve activity in unanaesthetized dogs

1974 • 21 citations

The Gulstonian Lectures on Anaemia

1881 • 20 citations

On the mechanism of the pressor response due to propranolol.

1968 • 19 citations

Central noradrenergic mechanisms and the cardiovascular effects of intracerebroventricular (+)- and (−)-propranolol in the conscious rabbit

1975 • 16 citations

Lack of antihypertensive effects of chronic administration of DL-propranolol in Grollman rats.

1973 • 15 citations

Central beta-adrenoceptor sites and ouabain action

1974 • 15 citations

Mechanism of the antagonism of the hypotensive action of guanethidine by propranolol

1970 • 15 citations

CARDIOVASCULAR RESPONSES PRODUCED BY THE INJECTION OF ISOPRENALINE AND PROPRANOLOL INTO THE CEREBRAL VENTRICLES OF THE UNANAESTHETIZED DOG

1974 • 14 citations

DIFFERENCES IN THE CARDIAC AND PRESSOR RESPONSES TO PROPRANOLOL OF RATS AND GUINEA PIGS

1974 • 14 citations

The effect of D- and DL-propranolol on blood pressure and cerebral norepinephrine in rats with DOCA-hypertension.

1972 • 14 citations

HYPOTENSIVE EFFECT OF ANGIOTENSIN-CONVERTING-ENZYME INHIBITOR SQ 20,881

1974 • 13 citations

Mechanism of Beta-Blockade Hypotension

1972 • 10 citations

Angiotensin Inhibition

1974 • 8 citations

THE EFFECTS OF PROCAINE INJECTED INTO THE CEREBRAL VENTRICLES OF CONSCIOUS AND ANAESTHETIZED DOGS

1965 • 7 citations

Sulfonylurea inhibition of protein synthesis in islets: preferential effect on proinsulin

1974 • 6 citations

Propranolol in hypertension

1971 • 6 citations

Inhibition of hypertensive reflexes by propranolol.

1974 • 6 citations

PRACTOLOL‐PROPRANOLOL

1974 • 6 citations

A comparison of propranolol and prindolol in the treatment of essential hypertension.

1974 • 4 citations

Hypotensive Effect of Propranolol

1969 • 3 citations

Renin-Sodium Profiling and Antihypertensive Response to Beta Blockade

1975 • 2 citations

Deleted Work

1955 • 0 citations