RBP-J_krepression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2

Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23

1990 • 585 citations

Genetic analysis of immortalizing functions of Epstein–Barr virus in human B lymphocytes

1989 • 553 citations

The suppressor of hairless protein participates in notch receptor signaling

1994 • 547 citations

Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation.

1989 • 491 citations

Mediation of Epstein-Barr Virus EBNA2 Transactivation by Recombination Signal-Binding Protein J _κ

1994 • 462 citations

The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein.

1994 • 352 citations

Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1

1990 • 319 citations

EBNA-2 and EBNA-LP cooperate to cause G0 to G1 transition during immortalization of resting human B lymphocytes by Epstein-Barr virus.

1994 • 298 citations

Masking of the CBF1/RBPJ _κ Transcriptional Repression Domain by Epstein-Barr Virus EBNA2

1995 • 296 citations

Recognition sequence of a highly conserved DNA binding protein RBP-J_x

1994 • 287 citations

Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates

1992 • 264 citations

B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2.

1995 • 255 citations

Epstein-Barr virus (EBV) induces expression of B-cell activation markers on in vitro infection of EBV-negative B-lymphoma cells.

1987 • 254 citations

Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.

1994 • 218 citations

Epstein-Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein

1990 • 208 citations

Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes.

1990 • 196 citations

Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation

1991 • 194 citations

The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein.

1993 • 187 citations

Stable transfection of Epstein-Barr virus (EBV) nuclear antigen 2 in lymphoma cells containing the EBV P3HR1 genome induces expression of B-cell activation molecules CD21 and CD23

1990 • 185 citations

The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor.

1994 • 169 citations

The level of c-fgr RNA is increased by EBNA-2, an Epstein-Barr virus gene required for B-cell immortalization

1990 • 168 citations

Epstein-Barr virus-encoded nuclear antigen 2 activates the viral latent membrane protein promoter by modulating the activity of a negative regulatory element.

1990 • 168 citations

Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappa

1995 • 167 citations

Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein gene

1991 • 165 citations

Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless.

1994 • 160 citations

EBNA-2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virus

1991 • 158 citations

A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif

1989 • 157 citations

The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements.

1994 • 151 citations

Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis

1994 • 144 citations

The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoter.

1993 • 144 citations

The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development

1992 • 116 citations

Epstein-Barr virus nuclear antigen 3C is a transcriptional regulator

1995 • 114 citations

Genetic and Biochemical Evidence That EBNA 2 Interaction with a 63-kDa Cellular GTG-Binding Protein Is Essential for B Lymphocyte Growth Transformation by EBV

1994 • 97 citations

Mutational Analysis of the Herpes Simplex Virus Type 1 Trans-inducing Factor Vmw65

1988 • 96 citations

The Epstein-Barr Virus Determined Nuclear Antigens EBNA-3A, -3B, and -3C Repress EBNA-2-Mediated Transactivation of the Viral Terminal Protein 1 Gene Promoter

1994 • 86 citations

The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence.

1991 • 67 citations

Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin J_xsegment

1989 • 65 citations

Human Jk Recombination Signal Binding Protein Gene (IGKJRB): Comparison with Its Mouse Homologue

1993 • 59 citations

The Recombination Signal Sequence-Binding Protein RBP-2N Functions as a Transcriptional Repressor

1994 • 59 citations

A region of herpes simplex virus VP16 can substitute for a transforming domain of Epstein-Barr virus nuclear protein 2.

1992 • 52 citations

Host cell and EBNA-2 regulation of Epstein-Barr virus latent-cycle promoter activity in B lymphocytes

1992 • 48 citations

Biochemical Characterization of Epstein-Barr Virus Nuclear Antigen 3A and 3C Proteins

1994 • 23 citations