Purification of Soluble Cytochrome b 5 as a Component of the Reductive Activation of Porcine Methionine Synthase

Methods of Enzymatic Analysis

1974 • 6,512 citations

Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

1969 • 1,846 citations

A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians

1992 • 1,686 citations

Simultaneous determination of hemes a, b, and c from pyridine hemochrome spectra

1987 • 885 citations

Hyperhomocyst(e)inemia as a Risk Factor for Occlusive Vascular Disease

1992 • 726 citations

Three-dimensional structure of NADPH–cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes

1997 • 722 citations

Serum Total Homocysteine and Coronary Heart Disease

1995 • 668 citations

Cytochrome b 5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer

1998 • 537 citations

Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study.

1993 • 460 citations

A Form of Cytochrome b ₅ That Contains an Additional Hydrophobic Sequence of 40 Amino Acid Residues

1971 • 453 citations

Methionine metabolism in mammals. Distribution of homocysteine between competing pathways.

1984 • 414 citations

Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders

1996 • 399 citations

Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria

1998 • 386 citations

STRUCTURE-BASED PERSPECTIVES ON B₁₂-DEPENDENT ENZYMES

1997 • 323 citations

Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease.

1984 • 290 citations

Catalysis of Methaemoglobin Reduction by Erythrocyte Cytochrome b5 and Cytochrome b5 Reductase

1971 • 282 citations

NADPH-cytochrome P-450 oxidoreductase: flavin mononucleotide and flavin adenine dinucleotide domains evolved from different flavoproteins

1986 • 241 citations

Cytochrome b5 reduction by NADPH-cytochrome P-450 reductase.

1979 • 199 citations

Lack of Electron Transfer from Cytochrome b5 in Stimulation of Catalytic Activities of Cytochrome P450 3A4

1996 • 192 citations

[18] Isolation of Rough and Smooth Microsomes—General

1974 • 181 citations

Activation of Methionine Synthetase by a Reduced Triphosphopyridine Nucleotide-dependent Flavoprotein System

1974 • 153 citations

Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities.

1994 • 152 citations

Mechanism of reductive activation of cobalamin-dependent methionine synthase: an electron paramagnetic resonance spectroelectrochemical study

1990 • 147 citations

The Yin-Yang of cobalamin biochemistry

1997 • 144 citations

Defects in human methionine synthase in cblG patients

1996 • 115 citations

Plasma homocyst(e)ine and arterial occlusive diseases: a mini-review

1995 • 112 citations

Molecular basis of phenotype expression in homocystinuria

1994 • 107 citations

Altered vitamin B12 metabolism in fibroblasts from a patient with megaloblastic anemia and homocystinuria due to a new defect in methionine biosynthesis.

1984 • 106 citations

Assignment of enzymic function to specific protein regions of cobalamin-dependent methionine synthase from Escherichia coli

1993 • 105 citations

Homocystinuria and Megaloblastic Anemia Responsive to Vitamin B₁₂Therapy

1984 • 92 citations

On the mechanism of action of cytochrome P-450. Oxidation and reduction of the ferrous dioxygen complex of liver microsomal cytochrome P-450 by cytochrome b5.

1984 • 86 citations

Activation of methionine synthase: Further characterization of the flavoprotein system

1977 • 84 citations

Effect of heme orientation on the reduction potential of cytochrome b5

1988 • 83 citations

NADPH−Flavodoxin Reductase and Flavodoxin fromEscherichia coli: Characteristics as a Soluble Microsomal P450 Reductase

1998 • 80 citations

Purification and kinetic mechanism of a mammalian methionine synthase from pig liver.

1994 • 77 citations

Demonstration That Mammalian Methionine Synthases Are Predominantly Cobalamin-loaded

1995 • 75 citations

The Reduction Potential of Cytochrome b₅ Is Modulated by Its Exposed Heme Edge

1998 • 69 citations

Soluble cytochrome b5 from human erythrocytes

1972 • 69 citations

Characterization of components of the anaerobic ribonucleotide reductase system from Escherichia coli.

1992 • 62 citations

Defects in Auxiliary Redox Proteins Lead to Functional Methionine Synthase Deficiency

1997 • 53 citations

Changes in Protonation Associated with Substrate Binding and Cob(I)alamin Formation in Cobalamin-Dependent Methionine Synthase

1997 • 46 citations

[17] Preparation of membrane fractions

1990 • 44 citations

Recombinant Human Erythrocyte Cytochrome b5

1994 • 33 citations

Methionine synthase from pig liver

1997 • 32 citations

Isolation of a cobalamin containing 5-methyltetrahydrofolate-homocysteine transmethylase from mammalian kidney

1971 • 30 citations

The Isolation and Characterization of the Soluble and Membrane-Bound Porcine Cytochrome b5cDNAs

1997 • 13 citations