Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers*

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

THE PHENOMENON OF THE ACUTE PHASE RESPONSE*

1982 • 1,498 citations

Analysis of Variance

1987 • 1,465 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Interleukin 10 protects mice from lethal endotoxemia.

1993 • 807 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells [published erratum appears in Blood 1990 Dec 1;76(11):2420]

1990 • 540 citations

IL-10 inhibits human T cell proliferation and IL-2 production.

1992 • 491 citations

The microbicidal activity of interferon‐γ‐treated macrophages against Trypanosoma cruzi involves an L‐arginine‐dependent, nitrogen oxide‐mediated mechanism inhibitable by interleukin‐10 and transforming growth factor‐β

1992 • 437 citations

A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.

1995 • 415 citations

Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes

1994 • 396 citations

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

1992 • 384 citations

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1990 • 347 citations

Identification and induction of keratinocyte-derived IL-10.

1992 • 342 citations

A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide.

1990 • 339 citations

Noncompartmental Analysis Based on Statistical Moment Theory

1982 • 274 citations

Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10 [see comments]

1992 • 247 citations

Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10.

1993 • 241 citations

Production of interleukin-1 receptor antagonist and interleukin-1 beta by peripheral blood mononuclear cells is differentially regulated

1991 • 201 citations

Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes.

1995 • 201 citations

Concentrations of Immunoreactive Human Tumor Necrosis Factor Alpha Produced by Human Mononuclear Cells In Vitro

1988 • 172 citations

Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock

1993 • 166 citations

Characterization of interleukin-10 receptors on human and mouse cells.

1993 • 161 citations

Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human interleukin-10 in healthy volunteers

1996 • 153 citations

Interleukin-10 gene knock-out mice: a model of chronic inflammation

1995 • 118 citations

Development and use of a radioimmunoassay for human interleukin-1 beta.

1987 • 106 citations

Cytokine mRNA expression during an in vitro response of human B lymphocytes: kinetics of B cell tumor necrosis factor alpha, interleukin (IL)6, IL-10, and transforming growth factor beta 1 mRNAs.

1993 • 67 citations

Detection of Tumor Necrosis Factor Soluble Receptor p55 in Blood Samples from Healthy and Endotoxemic Humans

1993 • 62 citations

A radioimmunoassay for human interleukin-1 alpha: measurement of IL-1 alpha produced in vitro by human blood mononuclear cells stimulated with endotoxin.

1988 • 55 citations

CD3+4-8- alpha beta T cell population with biased T cell receptor V gene usage. Presence in bone marrow and possible involvement of IL-3 for their extrathymic development.

1992 • 34 citations

Detection of soluble IL-1 receptor type II (IL-1sRII) in sera and plasma from healthy volunteers

1994 • 5 citations