A "Trans" Perspective on the Control of Immunoglobulin C Gene Expression

A plaque assay for all cells secreting Ig of a given type or class

1976 • 1,034 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends

1980 • 562 citations

Limiting Dilution Analysis of Cells in the Immune System

1980 • 325 citations

Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte

1977 • 309 citations

Organization of immunoglobulin heavy chain genes and allelic deletion model.

1978 • 297 citations

The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes

1981 • 260 citations

Subclass restriction of murine antibodies. II. The IgG plaque-forming cell response to thymus-independent type 1 and type 2 antigens in normal mice and mice expressing an X-linked immunodeficiency.

1980 • 258 citations

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

1980 • 213 citations

Sequential Expression of Immunoglobulin on Developing Mouse B Lymphocytes: A Systematic Survey That Suggests a Model for the Generation of Immunoglobulin Isotype Diversity

1978 • 211 citations

Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D

1980 • 188 citations

Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line

1982 • 173 citations

Specific T helper cells that activate B cells polyclonally. In vitro enrichment and cooperative function.

1980 • 124 citations

Mouse Immunoglobulin D: Messenger RNA and Genomic DNA Sequences

1980 • 123 citations

Synthesis of Multiple Immunoglobulin Classes by Single Lymphocytes

1977 • 109 citations

Ability of antigen-specific helper cells to effect a class-restricted increase in total Ig-secreting cells in spleens after immunization with the antigen.

1979 • 98 citations

Rearrangements of Immunoglobulin Genes during Differentiation and Evolution

1981 • 95 citations

REGULATION OF CELLULAR ANTIBODY SYNTHESIS

1968 • 86 citations

B-cell activation by helper cells is a two-step process

1981 • 78 citations

Successive switching of antibody isotypes expressed within the lines of a B-cell clone.

1980 • 71 citations

Switch in Immunoglobulin Class Production Observed in Single Clones of Committed Lymphocytes

1978 • 68 citations

Immunoglobulin C‐gene expression. I. The commitment to IgG subclass of secretory cells is determined by the quality of the nonspecific stimuli

1980 • 65 citations

B-cell growth factor: distinction from T-cell growth factor and B-cell maturation factor.

1982 • 61 citations

Frequencies of background immunoglobulin-secreting cells in mice as a function of organ, age, and immune status

1981 • 59 citations

‘Background’ immunoglobulin production: measurement, biological significance and regulation

1982 • 59 citations

Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin λ2b-chain gene

1980 • 54 citations

Stimulation of murine B lymphocytes to IgG synthesis and secretion by the mitogens lipopolysaccharide and lipoprotein and its inhibition by anti‐immunoglobulin antibodies

1978 • 51 citations

Linkage of the four gamma subclass heavy chain genes.

1981 • 39 citations

Cell Differentiation in the Presence of Cytochalasin B: Studies on the “Switch” to IgG Secretion after Polyclonal B Cell Activation

1979 • 35 citations

Shared antigenic determinants by mitogen receptors and antibody molecules to the same thymus-independent antigen.

1978 • 35 citations

MHC restriction of male-antigen-specific T helper cells collaborating in antibody responses

1982 • 30 citations

Intraclonal diversification in immunoglobulin isotype secretion: an analysis of switch probabilities.

1982 • 28 citations

The production of membrane or secretory forms of immunoglobulins is regulated by C-gene-specific signals

1982 • 25 citations

Immunoglobulin isotype expression II. Frequency analysis in mitogen‐reactive B cells

1981 • 22 citations

Immunoglobulin C‐gene expression. III. Possible induction of specific genetic events in activated B lymphocytes by the polyclonal stimuli driving clonal expansion

1982 • 12 citations

Ontogenic development of B cell reactivities to cooperative cell signals: Dissociation between proliferation and antibody secretion

1982 • 10 citations

Quantitative Aspects of the Nonspecific Humoral Immune Response to Sheep Erythrocytes

1982 • 10 citations

Isotype commitment in the in vivo immune responses. I. Antigen-dependent specific and polyclonal plaque-forming cell responses by B lymphocytes induced to extensive proliferation.

1982 • 7 citations