Mechanism of action of papain: aryldehydroalanines as spectroscopic probes of acyl enzyme formation

Chemistry of the amino acids

1961 • 1,404 citations

The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis

1964 • 1,214 citations

Über ein allgemeines Verfahren der Peptid‐Synthese

1932 • 769 citations

CRYSTALLINE PAPAIN

1954 • 456 citations

Mapping the active site of papain with the aid of peptide substrates and inhibitors

1970 • 410 citations

The Spectrophotometric Determination of the Operational Normality of an α-Chymotrypsin Solution

1961 • 407 citations

Verbesserte Synthese von tert.‐Butyloxycarbonyl‐aminosäuren durch pH‐Stat‐Reaktion

1967 • 383 citations

Cleavage of N-Carbobenzoxy Groups by dry Hydrogen Bromide and Hydrogen Chloride

1952 • 378 citations

Structure of crystalline α-chymotrypsin

1970 • 344 citations

The Structure of Papain

1971 • 242 citations

Titration of Acids in Nonaqueous Solvents

1951 • 213 citations

THE RÔLE OF SPECIFICITY IN THE ENZYMATIC SYNTHESIS OF PROTEINS

1937 • 192 citations

Aldehydes as Inhibitors of Papain

1972 • 169 citations

The Purification of Papain by Affinity Chromatography

1970 • 160 citations

Spectrophotometric Identification of an Active Site-specific Acyl Glyceraldehyde 3-Phosphate Dehydrogenase

1968 • 153 citations

The Preparation and Properties of trans-Cinnamoyl-Papain¹

1966 • 119 citations

Titration of Bases in Nonaqueous Solvents

1950 • 111 citations

The Kinetics of the Papain-Catalyzed Hydrolysis of Esters of Carbobenzoxyglycine. Evidence for an Acyl-Enzyme Intermediate^*

1966 • 105 citations

Spectrophotometric Investigations of the Mechanism of α-Chymotrypsin-catalyzed Hydrolyses. Detection of the Acyl-enzyme Intermediate^1-3

1962 • 104 citations

Beiträge zur Peptidsynthese, V. Darstellung und peptidsynthetische Verwendung von O‐Benzyl‐L‐tyrosin

1958 • 84 citations

Spectrophotometric Identification of Acyl Enzyme Intermediates^*

1965 • 81 citations

The Resolution of Racemic α-Amino Acids

1954 • 68 citations

PEPTIDES OF DEHYDROGENATED AMINO ACIDS

1943 • 67 citations

Evidence for conformational restrictions within the active site of acyl papains which influence the rates of hydrolysis

1970 • 47 citations

Preparation of Benzyl and p-Nitrobenzyl Esters of Amino Acids¹

1961 • 46 citations

The Mechanism of Trypsin-catalyzed Hydrolyses. The Cinnamoyl-trypsin Intermediate^1-3

1962 • 46 citations

Activation of a Covalent Enzyme-Substrate Bond by Noncovalent Interaction with an Effector

1973 • 42 citations

Titration of Bases in Dioxane

1950 • 42 citations

New Methods of Introducing the Carbo-t-butoxy Protective Group. Preparation of t-Butyl Cyanoformate¹

1960 • 39 citations

Synthese einer geschützten Pentapeptid‐Sequenz des Tyrocidins A unter Verwendung farbiger Schutzgruppen und des p‐Nitrobenzyl‐Restes

1959 • 39 citations

13 Papain, X-Ray Structure

1971 • 38 citations

Synthese des Tyrosins

1883 • 38 citations

Optical properties and the chemical nature of acylchymotrypsin linkages

1967 • 36 citations

The Acyl-enzyme Intermediate, trans-Cinnamoylpapain

1964 • 35 citations

Kinetics and thermodynamics of the reactions of acyl-papains. Effects of pH, temperature, solvents, ionic strength, and added nucleophiles

1971 • 17 citations

Product inhibition of papain action

1964 • 13 citations

Acyl derivatives of alpha-chymotrypsin

1967 • 11 citations

Interpretation of the ultraviolet spectrum of trans-cinnamoyl-α-chymotrypsin

1963 • 10 citations

N-Benzyloxycarbonyl amino acids as virtual substrates for papain

1964 • 10 citations

Binding of competitive (product) inhibitors to papain in the active and inactive state

1970 • 8 citations

Conjugate addition to activated .beta.-arylacrylic acid derivatives. Thiolate anions

1969 • 2 citations