Voltage clamping of multicellular myocardial preparations: Capabilities and limitations of existing methods

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo

1952 • 2,384 citations

Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle

1977 • 1,745 citations

Measurement of current‐voltage relations in the membrane of the giant axon of Loligo

1952 • 1,655 citations

Reconstruction of the action potential of ventricular myocardial fibres

1977 • 1,418 citations

Electric current flow in excitable cells

1976 • 1,353 citations

The effect of the cardiac membrane potential on the rapid availability of the sodium‐carrying system

1955 • 763 citations

Voltage clamp experiments in striated muscle fibres

1970 • 522 citations

Divalent cations as charge carriers in excitable membranes

1973 • 516 citations

Electrical constants of trabecular muscle from mammalian heart

1970 • 488 citations

Existence and role of a slow inward current during the frog atrial action potential

1969 • 449 citations

Ionic channels in nerve membranes

1970 • 416 citations

Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres.

1976 • 407 citations

Brief Reviews Exchange of Calcium Ions in the Mammalian Myocardium

1974 • 350 citations

A study of the ion selectivity and the kinetic properties of the calcium dependent slow inward current in mammalian cardiac muscle.

1977 • 344 citations

Slow recovery from inactivation of inward currents in mammalian myocardial fibres

1974 • 325 citations

Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers.

1975 • 320 citations

The diffusion of radiopotassium across intercalated disks of mammalian cardiac muscle

1966 • 308 citations

The effects of external cations and ouabain on the intracellular sodium activity of sheep heart Purkinje fibres

1977 • 307 citations

Heart: Excitation and Contraction

1971 • 277 citations

A new method for measuring membrane potentials with external electrodes

1954 • 274 citations

Changes in membrane currents in bullfrog atrium produced by acetylcholine.

1976 • 259 citations

Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium

1975 • 258 citations

Voltage clamp experiments on ventricular myocardial fibres

1970 • 255 citations

Relationship between internal calcium and outward current in mammalian ventricular muscle; a mechanism for the control of the action potential duration?

1976 • 250 citations

Textbook of General Physiology

1937 • 246 citations

Is potassium conductance of cardiac Purkinje fibres controlled by [Ca2+]i?

1975 • 233 citations

Membrane currents in the rabbit sinoatrial node cell as studied by the double microelectrode method

1976 • 230 citations

Inward membrane currents in mammalian myocardium

1972 • 223 citations

Comparative physiology of the cardiac pacemaker mechanism.

1978 • 207 citations

Voltage clamp technique in mammalian cardiac fibres

1964 • 203 citations

The time and voltage dependence of the slow outward current in cardiac Purkinje fibres

1966 • 199 citations

Calcium and potassium systems of a giant barnacle muscle fibre under membrane potential control

1973 • 176 citations

Inotropic and electrophysiological actions of verapamil and D600 in mammalian myocardium

1975 • 174 citations

Effects of low-chloride solutions on action potentials of sheep cardiac Purkinje fibers.

1977 • 155 citations

The recovery of resting potential and input resistance in sheep heart injured by knife or laser

1970 • 149 citations

Depletion and accumulation of potassium in the extracellular clefts of cardiac Purkinje fibers during voltage clamp hyperpolarization and depolarization

1977 • 143 citations

Excitation—contraction coupling in frog ventricle: evidence from voltage clamp studies

1971 • 139 citations

Membrane currents underlying activity in frog sinus venosus

1977 • 132 citations

Membrane potential and slow inward current dependence of frog cardiac mechanical activity

1972 • 130 citations

A time- and voltage-dependent potassium current in the rabbit sinoatrial node cell

1976 • 127 citations

Potassium conductance changes in skeletal muscle and the potassium concentration in the transverse tubules

1972 • 127 citations

Membrane currents in cat myocardium: separation of inward and outward components

1978 • 125 citations

Membrane Potentials of the Lobster Giant Axon Obtained by Use of the Sucrose-Gap Technique

1962 • 125 citations

Cat Heart Muscle in Vitro

1962 • 119 citations

On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium.

1977 • 116 citations

Some limitations of the double sucrose gap, and its use in a study of the slow outward current in mammalian ventricular muscle. With an Appendix

1974 • 110 citations

Calcium ion activity in physiological salt solutions: Influence of anions substituted for chloride

1975 • 109 citations

Characteristics of the rectifying properties of the sino‐atrial node cell of the rabbit.

1976 • 92 citations

Effects of stimulating the acetylcholine receptor on the current‐voltage relationships of the smooth muscle membrane studied by voltage clamp of potential recorded by micro‐electrode.

1975 • 85 citations

Gating in Sodium Channels of Nerve

1976 • 85 citations

The voltage clamp of multicellular preparations

1978 • 81 citations

Potassium accumulation and depletion in frog atrial muscle.

1976 • 79 citations

Role of intracellular calcium in the transient outward current of calf Purkinje fibres

1977 • 79 citations

Membrane current and contraction in frog atrial fibres

1972 • 76 citations

On the voltage-dependent action of tetrodotoxin

1977 • 75 citations

Mechanical activity and ionic currents in frog atrial trabeculae

1972 • 74 citations

Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium

1975 • 74 citations

Theory of a membrane-voltage clamp with discontinuous feedback through a pulsed current clamp

1974 • 66 citations

Voltage clamp analysis of embryonic heart cell aggregates.

1979 • 66 citations

Reduction of potassium permeability by chloride substitution in cardiac cells.

1977 • 65 citations

Effect of lidocaine on the early inward transient current in sheep cardiac Purkinje fibers.

1975 • 64 citations

Calcium‐sodium antagonism on the frog's heart: a voltage‐clamp study.

1976 • 63 citations

Volume and Twitch Tension Changes in Single Muscle Fibers in Hypertonic Solutions

1968 • 61 citations

Cardiac Purkinje fibres

1977 • 61 citations

The voltage clamp and cardiac electrophysiology.

1975 • 59 citations

Current-voltage relations in ventricular muscle preparations from different species

1978 • 58 citations

Axon voltage-clamp simulations. A multicellular preparation

1975 • 54 citations

Electrophysiologic correlates of the inotropic effects of Isoproterenol in canine myocardium

1975 • 53 citations

A synthetic strand of cardiac muscle: its passive electrical properties.

1975 • 53 citations

Axon voltage-clamp simulations. I. Methods and tests

1975 • 52 citations

Design of a fast voltage clamp for biological membranes, using discontinuous feedback

1974 • 51 citations

An Assessment of the Double Sucrose-Gap Voltage Clamp Technique as Applied to Frog Atrial Muscle

1974 • 49 citations

Ionic membrane conductance during the time course of the cardiac action potential.

1977 • 45 citations

Measurement of transmembrane potential and current in cardiac muscle: a new voltage clamp method.

1977 • 43 citations

Effects of sucrose solution on the longitudinal tissue resistivity of trabecular muscle from mammalian heart

1973 • 41 citations

Electrical characteristics of frog atrial trabeculae in the double sucrose gap

1975 • 39 citations

Voltage Clamp of Cardiac Muscle

1972 • 39 citations

The influence of non‐uniformity on the analysis of potassium currents in heart muscle.

1976 • 36 citations

Cellular Potentials of Intact Mammalian Hearts

1952 • 33 citations

Origin of Axon Membrane Hyperpolarization under Sucrose-Gap

1966 • 33 citations

Respiratory oscillations in discharge frequency of chemoreceptor afferents in sinus nerve and anaesthetized cats at normal and low arterial oxygen tensions.

1978 • 28 citations

Voltage clamp analysis in isolated cardiac fibres as performed with two different perfusion chambres for double sucrose gap

1976 • 27 citations

Use of rubber membranes to improve sucrose-gap and other electrical recording techniques

1969 • 27 citations

Voltage Clamp of Cardiac Muscle in a Double Sucrose Gap

1973 • 26 citations

Voltage clamp with double sucrose gap technique. External series resistance compensation

1976 • 26 citations

Characteristics and tachyphylaxis of gastrin‐stimulated gastric acid secretion in the cat.

1978 • 25 citations

Some technical improvements for the voltage clamp with the double sucrose gap

1976 • 19 citations

An equivalent circuit for small atrial trabeculae of frog

1975 • 16 citations

Electrical and mechanical effects of procaine on mammalian heart muscle

1971 • 16 citations

Effects of Anions on Frog Ventricle

1973 • 15 citations

Effects of the replacement of chloride by methylsulphate on the membrane currents in frog atrial trabeculae

1977 • 12 citations

Axon voltage-clamp simulations. II. Double sucrose-gap method

1975 • 10 citations

Membrane conductance measurements in cat ventricular muscle

1978 • 8 citations

Double sucrose gap voltage clamp in cardiac muscle

1977 • 5 citations

A Textbook of General Physiology

1957 • 5 citations

A simultaneous measurement of the membrane voltage, current and tension on the bullfrog ventricle under voltage clamp condition.

1970 • 5 citations

Optical studies on contractile structures in frog muscles. Analysis of components at rest and of responses related to contractile events

1976 • 1 citations