Direct Modification of Somatotrope Function by Long-Term Leptin Treatment of Primary Cultured Ovine Pituitary Cells

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996 • 2,048 citations

Circulating Ghrelin Levels Are Decreased in Human Obesity

2001 • 1,999 citations

Role of leptin in hypothalamic–pituitary function

1997 • 744 citations

Dual Defects in Pulsatile Growth Hormone Secretion and Clearance Subserve the Hyposomatotropism of Obesity in Man*

1991 • 481 citations

Impaired Growth Hormone Responses to Growth Hormone–Releasing Factor in Obesity

1984 • 420 citations

Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay.

1995 • 371 citations

Expression and Localization of the Leptin Receptor in Endocrine and Neuroendocrine Tissues of the Rat

1997 • 313 citations

Leptin and Leptin Receptor Expression in Normal and Neoplastic Human Pituitary: Evidence of a Regulatory Role for Leptin on Pituitary Cell Proliferation1

1999 • 237 citations

Nitric Oxide Mediates Leptin-Induced Luteinizing Hormone-Releasing Hormone (LHRH) and LHRH and Leptin-Induced LH Release from the Pituitary Gland

1997 • 224 citations

Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study

1996 • 218 citations

Leptin receptor mRNA is expressed in ewe anterior pituitary and adipose tissues and is differentially expressed in hypothalamic regions of well-fed and feed-restricted ewes

1997 • 203 citations

Leptin Is a Potent Stimulator of Spontaneous Pulsatile Growth Hormone (GH) Secretion and the GH Response to GH-Releasing Hormone*

1998 • 171 citations

Hyperleptinaemia: the Missing Link in the Metabolic Syndrome?

1997 • 164 citations

Influence of Endogenous Leptin Tone on the Estrous Cycle and Luteinizing Hormone Pulsatility in Female Rats

1997 • 158 citations

Effect of Restricted Feeding on the Concentrations of Growth Hormone (GH), Gonadotropins, and Prolactin (PRL) in Plasma, and on the Amounts of Messenger Ribonucleic Acid for GH, Gonadotropin Subunits, and PRL in the Pituitary Glands of Adult Ovariectomized Ewes*

1990 • 147 citations

Evidence for a Leptin-Neuropeptide Y Axis for the Regulation of Growth Hormone Secretion in the Rat

1998 • 131 citations

Localization of Leptin Receptor-Like Immunoreactivity in the Corticotropes, Somatotropes, and Gonadotropes in the Ovine Anterior Pituitary¹

2000 • 122 citations

Enhanced Growth Hormone (GH) Responsiveness to GH-Releasing Hormone After Dietary Manipulation in Obese and Nonobese Subjects*

1988 • 116 citations

Circadian Rhythm of Plasma Leptin Levels in Upper and Lower Body Obese Women: Influence of Body Fat Distribution and Weight Loss

1998 • 108 citations

Human Fetal Pituitary Expresses Functional Growth Hormone-Releasing Peptide Receptors¹

1998 • 67 citations

The in vitro Effect of Leptin onBasal and Growth Hormone-Releasing Hormone-StimulatedGrowth Hormone Secretion from theOvine Pituitary Gland

1998 • 54 citations

The Human Growth Hormone-Releasing Hormone Transgenic Mouse as a Model of Modest Obesity: Differential Changes in Leptin Receptor (OBR) Gene Expression in the Anterior Pituitary and Hypothalamus after Fasting and OBR Localization in Somatotrophs*

1999 • 53 citations

Voltage-Dependent Potassium Currents in Ovine Somatotrophs and Their Function in Growth Hormone Secretion

1994 • 47 citations

Upregulation of Leptin Receptor Gene Expression in the Anterior Pituitary of Human Growth Hormone-Releasing Hormone Transgenic Mice

1998 • 43 citations

Human Fetal Pituitary Expresses Functional Growth Hormone-Releasing Peptide Receptors

1998 • 40 citations

The In Vitro Effect of Leptin on Growth Hormone Secretion from Primary Cultured Ovine Somatotrophs

2001 • 22 citations

IMPAIRED GROWTH HORMONE RESPONSE TO INSULIN‐INDUCED HYPOGLYCAEMIA IN OBESE PATIENTS: RESTORATION BLOCKED BY RITANSERIN AFTER FENFLURAMINE ADMINISTRATION

1990 • 18 citations

Construction and application of a multispecific competitor to quantify mRNA of matrix metalloproteinases and their tissue inhibitors in small human biopsies

1999 • 14 citations