Review article: gastrointestinal angiodysplasia - pathogenesis, diagnosis and management

Acquired von Willebrand Syndrome in Aortic Stenosis

2003 • 795 citations

Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review

2010 • 687 citations

Clinical outcomes of double-balloon endoscopy for the diagnosis and treatment of small-intestinal diseases

2004 • 647 citations

A Meta-Analysis of the Yield of Capsule Endoscopy Compared to Other Diagnostic Modalities in Patients with Obscure Gastrointestinal Bleeding

2005 • 636 citations

Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation.

1986 • 609 citations

American Gastroenterological Association (AGA) Institute Technical Review on Obscure Gastrointestinal Bleeding

2007 • 511 citations

Endothelial von Willebrand factor regulates angiogenesis

2010 • 451 citations

On the nature and etiology of vascular ectasias of the colon. Degenerative lesions of aging.

1977 • 446 citations

Platelet Dysfunction in Renal Failure

2004 • 444 citations

Gastrointestinal Bleeding in Aortic Stenosis

1958 • 413 citations

On the Nature and Etiology of Vascular Ectasias of the Colon

1977 • 389 citations

HEMATOLOGY: ISSUES IN THE DIALYSIS PATIENT: Platelet Dysfunction and End‐Stage Renal Disease

2006 • 371 citations

Urgent Colonoscopy for Evaluation and Management of Acute Lower Gastrointestinal Hemorrhage: A Randomized Controlled Trial

2005 • 338 citations

Angiodysplasia of the gastrointestinal tract.

1993 • 289 citations

Treatment of bleeding gastrointestinal vascular malformations with oestrogen-progesterone

1990 • 286 citations

A Prospective Study Comparing Video Capsule Endoscopy with Double-Balloon Enteroscopy in Patients with Obscure Gastrointestinal Bleeding

2005 • 280 citations

Guidelines on small bowel enteroscopy and capsule endoscopy in adults

2007 • 268 citations

Acute lower intestinal bleedingPart II: Etiology, therapy, and outcomes

1999 • 266 citations

Preliminary Comparison of Capsule Endoscopy and Double-Balloon Enteroscopy in Patients with Suspected Small-Bowel Bleeding

2006 • 243 citations

A multicenter, randomized, clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia

2001 • 237 citations

Review article: the management of lower gastrointestinal bleeding

2005 • 228 citations

Upper Gastrointestinal Bleeding in Patients with Chronic Renal Failure

1985 • 223 citations

Arteriovenous Malformations of the Bowel

1981 • 217 citations

Argon Plasma Coagulation in the Management of Symptomatic Gastrointestinal Vascular Lesions: Experience in 100 Consecutive Patients with Long-Term Follow-Up

2006 • 214 citations

Superselective Microcoil Embolization for the Treatment of Lower Gastrointestinal Hemorrhage

2003 • 209 citations

Efficacy of Thalidomide for Refractory Gastrointestinal Bleeding From Vascular Malformation

2011 • 208 citations

Meta‐analysis: capsule enteroscopy vs. conventional modalities in diagnosis of small bowel diseases

2005 • 208 citations

Argon Plasma Coagulation in Flexible Gastrointestinal Endoscopy: Pilot Experiences

1997 • 204 citations

Prospective Multicenter Trial Comparing Push-and-Pull Enteroscopy With the Single- and Double-Balloon Techniques in Patients With Small-Bowel Disorders

2010 • 204 citations

Push-and-Pull Enteroscopy in the Small Bowel Using the Double-Balloon Technique: Results of a Prospective European Multicenter Study

2005 • 202 citations

Clinical applications of the argon plasma coagulator

2004 • 194 citations

Gastrointestinal Angiodysplasia Associated with Aortic Valve Disease: Part of a Spectrum of Angiodysplasia of the Gut

1979 • 187 citations

Superselective Arterial Embolization for the Treatment of Lower Gastrointestinal Hemorrhage

2001 • 187 citations

Upper Gastrointestinal Hemorrhage and Transcatheter Embolotherapy: Clinical and Technical Factors Impacting Success and Survival

2001 • 186 citations

Uremic Bleeding: Pathogenesis and Therapy

1998 • 185 citations

Gastrointestinal bleeding, angiodysplasia, cardiovascular disease, and acquired von Willebrand syndrome

2003 • 180 citations

The efficacy of octreotide therapy in chronic bleeding due to vascular abnormalities of the gastrointestinal tract

1999 • 176 citations

Diagnostic and Therapeutic Impact of Double-balloon Enteroscopy

2006 • 175 citations

Diagnostic Yield and Therapeutic Impact of Double-Balloon Enteroscopy in a Large Cohort of Patients with Obscure Gastrointestinal Bleeding

2006 • 170 citations

Prevalence and natural history of colonic angiodysplasia among healthy asymptomatic people.

1995 • 169 citations

Single-balloon versus double-balloon endoscopy for achieving total enteroscopy: a randomized, controlled trial

2011 • 168 citations

Single- vs. double-balloon enteroscopy in small-bowel diagnostics: a randomized multicenter trial

2011 • 167 citations

Abnormal von Willebrand factor in bleeding angiodysplasias of the digestive tract

2001 • 160 citations

Long term results of treatment of vascular malformations of the gastrointestinal tract by neodymium Yag laser photocoagulation.

1985 • 158 citations

Upper gastrointestinal bleeding in patients with chronic renal failure: role of vascular ectasia.

1996 • 158 citations

Does Hormonal Therapy Have Any Benefit for Bleeding Angiodysplasia?

1992 • 151 citations

The Association of Unexplained Gastrointestinal Bleeding with Calcific Aortic Stenosis

1987 • 145 citations

Angiodysplasia as a Cause of Upper Gastrointestinal Bleeding

1985 • 143 citations

Endoscopic diagnosis and therapy of mucosal vascular abnormalities of the gastrointestinal tract occurring in elderly patients and associated with cardiac, vascular, and pulmonary disease

1980 • 141 citations

Increased Expression of Angiogenic Factors in Human Colonic Angiodysplasia

1999 • 139 citations

Accuracy of helical computed tomographic angiography for the diagnosis of colonic angiodysplasia

2000 • 135 citations

Angiodysplasia

1989 • 129 citations

Intraoperative enteroscopy for diagnosis and management of unexplained gastrointestinal bleeding

2000 • 128 citations

Vascular malformations of the gastrointestinal tract

2001 • 128 citations

Cessation of Recurrent Bleeding from Gastrointestinal Angiodysplasias After Aortic Valve Replacement

1986 • 126 citations

The tissue effect of argon plasma coagulation on esophageal and gastric mucosa

2000 • 125 citations

Yield of Repeat Wireless Video Capsule Endoscopy in Patients with Obscure Gastrointestinal Bleeding

2005 • 125 citations

A comparative evaluation of single-balloon enteroscopy and spiral enteroscopy for patients with mid-gut disorders

2010 • 121 citations

Small bowel enteroscopy and intraoperative enteroscopy for obscure gastrointestinal bleeding.

1991 • 120 citations

Long-Term Efficacy of Octreotide in the Prevention of Recurrent Bleeding from Gastrointestinal Angiodysplasia

2007 • 119 citations

Somatostatin Analogues in the Treatment of Recurrent Bleeding from Gastrointestinal Vascular Malformations: An Overview and Systematic Review of Prospective Observational Studies

2010 • 118 citations

Angiodysplasia in the Colon and Rectum

1985 • 118 citations

Estrogen-Progesterone Therapy for Bleeding Gastrointestinal Telangiectasias in Chronic Renal Failure

1986 • 114 citations

ANGIODYSPLASIA OF THE COLON

1982 • 113 citations

Endoscopic hemostatic devices

2001 • 109 citations

Treatment of Lower Gastrointestinal Bleeding: Vasopressin Infusion versus Embolization

2003 • 108 citations

The accuracy of technetium-99m-labeled red cell scintigraphy in localizing gastrointestinal bleeding.

1994 • 108 citations

Total peroral intraoperative enteroscopy for obscure GI bleeding using a dedicated push enteroscope: diagnostic yield and patient outcome

1999 • 107 citations

Role of intraoperative enteroscopy in obscure gastrointestinal bleeding of small bowel origin

1991 • 107 citations

The management of massive lower gastrointestinal bleeding.

1993 • 106 citations

Yield and impact of emergency capsule enteroscopy in severe obscure-overt gastrointestinal bleeding

2012 • 105 citations

Medical Therapy for Chronic Gastrointestinal Bleeding of Obscure Origin

1998 • 103 citations

Embolization for non-variceal upper gastrointestinal tract haemorrhage: A systematic review

2011 • 103 citations

Efficacy of colonic submucosal saline solution injection for the reduction of iatrogenic thermal injury

2002 • 102 citations

Uremic platelets have a functional defect affecting the interaction of von Willebrand factor with glycoprotein IIb-IIIa

1990 • 99 citations

Push enteroscopic cauterization: long-term follow-up of 83 patients with bleeding small intestinal angiodysplasia

1996 • 96 citations

Aortic Stenosis, Idiopathic Gastrointestinal Bleeding, and Angiodysplasia: Is There an Association? A Methodologic Critique of the Literature

1988 • 95 citations

Capsule Endoscopy or Angiography in Patients With Acute Overt Obscure Gastrointestinal Bleeding: A Prospective Randomized Study With Long-Term Follow-Up

2012 • 95 citations

Colonic gas explosion during therapeutic colonoscopy with electrocautery

2007 • 91 citations

Long-Term Outcome of Argon Plasma Ablation Therapy for Bleeding in 100 Consecutive Patients with Colonic Angiodysplasia

2006 • 91 citations

Prospective, cross-over, single-center trial comparing oral double-balloon enteroscopy and oral spiral enteroscopy in patients with suspected small-bowel vascular malformations

2011 • 90 citations

Endoscopic laser treatment of vascular anomalies of the upper gastrointestinal tract.

1985 • 90 citations

Endoscopic band ligation for control of nonvariceal upper GI hemorrhage: Comparison with bipolar electrocoagulation

2002 • 89 citations

Performance of antegrade double-balloon enteroscopy: comparison with push enteroscopy

2005 • 88 citations

Octreotide in the treatment of bleeding due to angiodysplasia of the small intestine.

1993 • 87 citations

Increased Prevalence of Aortic Stenosis in Patients With Arteriovenous Malformations of the Gastrointestinal Tract in Heyde Syndrome

2003 • 85 citations

Mucosal Vascular Malformations of the Gastrointestinal Tract: Clinical Observations and Results of Endoscopic Neodymium:Yttrium-Aluminum-Garnet Laser Therapy

1988 • 84 citations

Vascular Malformations of the Right Colon as a Cause of Bleeding in Patients with Aortic Stenosis

1974 • 84 citations

Octreotide in the treatment of gastrointestinal bleeding caused by angiodysplasia in two patients with von Willebrand's disease

2000 • 84 citations

Aortic Stenosis and Unexplained Gastrointestinal Bleeding

1961 • 83 citations

Idiopathic gastrointestinal bleeding and aortic stenosis

1974 • 83 citations

Long‐acting somatostatin analogues decrease blood transfusion requirements in patients with refractory gastrointestinal bleeding associated with angiodysplasia

2012 • 83 citations

Angiodysplasia of the colon: A cause of rectal bleeding

1978 • 83 citations

A prospective controlled evaluation of endoscopic detection of angiodysplasia and its association with aortic valve disease

1995 • 82 citations

Endoscopic Laser Treatment for Gastrointestinal Vascular Ectasias

1986 • 82 citations

Prospective comparison between double-balloon enteroscopy and spiral enteroscopy

2010 • 80 citations

Acquired von Willebrand's disease, platelet-release defect and angiodysplasia

1978 • 78 citations

Pharmacological Therapy of Vascular Malformations of the Gastrointestinal Tract

2006 • 78 citations

Diagnostic yield of colonoscopy based on symptoms

2008 • 75 citations

Colonic vascular ectasias and aortic stenosis: Coincidence or causal relationship?

1986 • 74 citations

Long-term results of treatment of vascular malformations of the gastrointestinal tract by neodymium YAG laser photocoagulation

1990 • 73 citations

Long‐acting octreotide as rescue therapy in chronic bleeding from gastrointestinal angiodysplasia

2007 • 72 citations

ACR Appropriateness Criteria® on Treatment of Acute Nonvariceal Gastrointestinal Tract Bleeding

2008 • 71 citations

Double- vs. single-balloon vs. spiral enteroscopy

2012 • 70 citations

In vivo characterization of colonic thermal injury caused by argon plasma coagulation

2002 • 68 citations

Angiodysplasia — an uncommon cause of colonic bleeding: Colonoscopic evaluation of 1,050 patients with rectal bleeding and anaemia

1987 • 67 citations

Gastrointestinal angiodysplasia: A possible component of von Willebrand's disease

1984 • 67 citations

An epidemiological study of Heyde's syndrome: an association between aortic stenosis and gastrointestinal bleeding.

2004 • 67 citations

Acute Gastrointestinal Hemorrhage

2009 • 66 citations

Second capsule endoscopy for patients with severe iron deficiency anemia

2004 • 65 citations

Long-acting octreotide is effective in controlling rebleeding angiodysplasia of the gastrointestinal tract

2001 • 64 citations

Gastrointestinal bleeding in von Willebrand disease

2006 • 63 citations

Argon plasma coagulation for prevention of recurrent bleeding from GI angiodysplasias

2004 • 61 citations

Resolution of Heyde's Syndrome of Aortic Stenosis and Gastrointestinal Bleeding after Aortic Valve Replacement

1986 • 61 citations

Thalidomide for the treatment of chronic gastrointestinal bleeding from angiodysplasias: a case series

2009 • 61 citations

Bleeding from the right colon associated with aortic stenosis

1971 • 59 citations

Aortic stenosis associated with gastrointestinal bleeding. A survey of 612 patients

1980 • 59 citations

Endovascular intervention for the treatment of acute arterial gastrointestinal hemorrhage

2002 • 58 citations

Angiodysplasia of the stomach and duodenum

1985 • 55 citations

Thalidomide in refractory bleeding due to gastrointestinal angiodysplasias

2012 • 52 citations

Angiodysplasia of the Upper Gastrointestinal Tract

1986 • 52 citations

Angiodysplasia of the colon: an expression of occlusive vascular disease.

1987 • 52 citations

Will transcatheter embolotherapy replace surgery in the treatment of gastrointestinal bleeding?

2001 • 52 citations

Successful Aortic Valve Replacement for Heyde Syndrome With Confirmed Hematologic Recovery

2006 • 52 citations

Surgical Treatment Concepts for Acute Lower Gastrointestinal Bleeding

2008 • 51 citations

Somatostatin in the Treatment of Gastrointestinal Bleeding Caused by Angiodysplasia

1996 • 51 citations

Double-Balloon Enteroscopy following Capsule Endoscopy in the Management of Obscure Gastrointestinal Bleeding: Outcome of a Combined Approach

2008 • 50 citations

Wireless capsule endoscopy in the investigation of patients with chronic renal failure and obscure gastrointestinal bleeding (preliminary data).

2006 • 49 citations

Macroscopic appearance of intestinal angiodysplasias under antiangiogenic treatment with thalidomide

2006 • 48 citations

Small Intestinal Angiodysplasia in the Elderly

1984 • 47 citations

A novel method of treating colonic angiodysplasia

2006 • 47 citations

A Pilot Study of Thalidomide in Recurrent GI Bleeding Due to Angiodysplasias

2007 • 46 citations

Vascular Ectasia of the Colon

1980 • 45 citations

Endoscopic Ligation for Non-Esophageal Variceal Upper Gastrointestinal Hemorrhage

1998 • 44 citations

Vascular Malformations of the Stomach and Duodenum: An Endoscopic Classification

1986 • 43 citations

Ethanolamine Injection for Sclerotherapy of Angiodysplasia of the Colon

1998 • 42 citations

Gastrointestinal haemorrhage from a second source in patients with colonic angiodysplasia

1987 • 40 citations

Idiopathic immune-mediated acquired von Willebrand's disease in a patient with angiodysplasia: Demonstration of an unusual inhibitor causing a functional defect and rapid clearance of von Willebrand factor

1999 • 39 citations

URGENT CAPSULE ENDOSCOPY IS USEFUL IN SEVERE OBSCURE‐OVERT GASTROINTESTINAL BLEEDING

2009 • 39 citations

In vivo evaluation of argon plasma coagulation in a porcine model

2007 • 39 citations

Changing epidemiology of gastrointestinal angiodysplasia with increasing recognition of clinically milder cases: angiodysplasia tend to produce mild chronic gastrointestinal bleeding in a study of 47 consecutive patients admitted from 1980-1989.

1992 • 39 citations

Does Hemodynamic Instability Predict Positive Technetium-Labeled Red Blood Cell Scintigraphy in Patients With Acute Lower Gastrointestinal Bleeding? A Review of 50 Patients

2005 • 38 citations

Transcatheter Treatment for Lower Gastrointestinal Hemorrhage

2004 • 36 citations

Somatostatin Therapy Ameliorates Chronic and Refractory Gastrointestinal Bleeding Caused by Diffuse Angiodysplasia in a Patient on Anticoagulation Therapy

2003 • 36 citations

Acquired von Willebrand disease in a patient with angiodysplasia resulting from immune‐mediated clearance of von Willebrand factor

1997 • 36 citations

Von Willebrand's disease and angiodysplasia treated with thalidomide

2006 • 35 citations

Clinical features of Japanese patients with colonic angiodysplasia

2007 • 34 citations

Wall Stress and Hypertension

2000 • 34 citations

Gastrointestinal bleeding, angiodysplasia of the colon and acquired von Willebrand's disease

1980 • 33 citations

A study of motility of normal human gastroduodenal region

1981 • 32 citations

Thalidomide as treatment for digestive tract angiodysplasias.

2006 • 31 citations

Laser treatment of intestinal vascular abnormalities

1989 • 31 citations

Usefulness of endoscopic band ligation for bleeding small bowel vascular lesions

2003 • 30 citations

Nd:YAG laser induces long-term remission in transfusion-dependent patients with watermelon stomach

2004 • 30 citations

Reduced Platelet Function and Role of Drugs in Acute Gastrointestinal Bleeding

2010 • 30 citations

Reassessment of the association between gastrointestinal arteriovenous malformations and aortic stenosis

1989 • 29 citations

[Estrogen and progestagen treatment in digestive hemorrhage caused by vascular malformations].

1995 • 28 citations

Prevalence of aortic valve stenosis in patients affected by gastrointestinal angiodysplasia.

1993 • 27 citations

Angiodysplasia and von willebrand's disease type IIB treated with estrogen/progesterone therapy

1992 • 27 citations

Octreótido long acting release para la hemorragia digestiva en pacientes de edad avanzada con comorbilidad

2009 • 27 citations

Spatial clustering of simultaneous nonhereditary gastrointestinal angiodysplasia

1992 • 27 citations

Treatment of Heyde's Syndrome by Aortic Valve Replacement

2011 • 26 citations

Colonic angiodysplasia

1989 • 23 citations

Twelve-year history of gastrointestinal bleeding in a patient with calcific aortic stenosis and hemorrhagic telangiectasia

1979 • 23 citations

Angiodysplasia in the renal patients: how to diagnose and how to treat?

1998 • 23 citations

Colonic explosion during endoscopic polypectomy: avoidable complication or bad luck?

2006 • 22 citations

Primary Balloon-assisted Enteroscopy in Patients With Obscure Gastrointestinal Bleeding

2010 • 21 citations

Recurrent Obscure Gastrointestinal Bleeding: Dilemmas and Success with Pharmacological Therapies. Case Series and Review

2009 • 21 citations

Use of endoclips to obliterate a colonic arteriovenous malformation before cauterization

2006 • 20 citations

Methylene Blue Enteric Mapping for Intraoperative Localization in Obscure Small Bowel Hemorrhage: Report of a New Technique and Literature Review

2012 • 20 citations

Vascular ectasia. Diagnosis and treatment by colonoscopy.

1988 • 19 citations

Role of hemoclips in a patient with cecal angiodysplasia at high risk of recurrent bleeding from antithrombotic therapy to maintain coronary stent patency: a case report

2005 • 18 citations

Therapeutic endoscopy and bleeding ulcers. Bipolar/multipolar electrocoagulation.

1990 • 17 citations

Endoscopic detachable mini-loop ligation for treatment of gastroduodenal angiodysplasia: case study of 11 patients with long-term follow-up

2004 • 17 citations

Efficacy of neodymium:YAG laser therapy for gastric antral vascular ectasia (GAVE) following hematopoietic cell transplant

2005 • 15 citations

Combined use of capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding.

2008 • 15 citations

The pattern of angiodysplasia of the gastrointestinal tract in a tropical country.

1985 • 15 citations

[Thalidomide for the treatment of recurrent gastrointestinal blood loss due to intestinal angiodysplasias].

2006 • 14 citations

Effectiveness and Safety of PRECISE APC for the Treatment of Bleeding Gastrointestinal Angiodysplasia - a Retrospective Evaluation

2011 • 13 citations

Acute gastrointestinal bleeding following aortic valve replacement in a patient with Heyde's sindrome. Case report.

2007 • 12 citations

Successful endoscopic clipping for bleeding from colonic angiodysplasia in a case of Heyde syndrome.

2010 • 11 citations

Aortic stenosis and unexplained gastrointestinal bleeding.

1967 • 11 citations

Endoscopic Band Ligation: Alternative Treatment Method in Nonvariceal Upper Gastrointestinal Hemorrhage

2002 • 10 citations

[Octreotide in the treatment of angiodysplasia in patients with advanced chronic renal failure].

2005 • 10 citations

Double-balloon endoscopy in the diagnosis and treatment of hemorrhage from retrovalvular angiodysplasias.

2008 • 10 citations

[Digestive haemorrhage due to angiodysplasia in dialysis patients. Treatment with conjugated estrogens].

2005 • 10 citations

[The mechanisms of thalidomide in treatment of angiodysplasia due to hypoxia].

2009 • 10 citations

Chronic bleeding caused by small bowel angiodysplasia: a problem of recognition and diagnosis.

1992 • 9 citations

Gastric angiodysplasia--a missed cause of gastrointestinal bleeding

1987 • 9 citations

BLEEDING ANGIODYSPLASIA: SHOULD WE CONCENTRATE MORE ON THE AORTIC VALVE THAN ON THE BOWEL?

2002 • 9 citations

Laser therapy and surgical treatment in transfusion-dependent patients with upper-gastrointestinal vascular ectasia

2006 • 8 citations

Successful application of haemoclips plus argon plasma coagulation for angioectasia bleeding with underlying arteriovenous malformation in the colon

2009 • 8 citations

Aortic stenosis. Gastrointestinal bleeding.

1975 • 6 citations

[Thalidomide therapy for gastrointestinal angiodysplasia].

2009 • 5 citations

Endoscopic band ligation of gastric angiodysplasia.

1998 • 4 citations

Aortic stenosis and gastrointestinal hemorrhage. Report of four cases.

1965 • 4 citations

Pedunculated Angiodysplasia of the Colon Treated with Endoscopic Resection: A Case Report

2005 • 4 citations

Angiodysplasia (vascular malformations) of the colon presenting as an acute abdomen

2012 • 3 citations

Endoscopic removal of a bleeding colonic polypoid angiodysplasia: case report.

2010 • 1 citations