Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First- and Third-generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations

DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS

2004 • 892 citations

CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants

2002 • 747 citations

A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants

2006 • 713 citations

Clinical relevance of genetic polymorphisms in the human CYP2C subfamily

2001 • 627 citations

Robust Nonparametric Statistical Methods

2010 • 606 citations

Clinical consequences of cytochrome P450 2C9 polymorphisms

2005 • 464 citations

A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction

2005 • 372 citations

Genotype???phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women

2003 • 261 citations

Validation of the five-drug “Pittsburgh cocktail” approach for assessment of selective regulation of drug-metabolizing enzymes*

1997 • 244 citations

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

1994 • 221 citations

An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients

2006 • 184 citations

Pharmacokinetics of losartan and its metabolite E‐3174 in relation to the CYP2C9 genotype

2002 • 175 citations

CYP2C19 Polymorphism and Proton Pump Inhibitors

2004 • 166 citations

Rapid Detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 Alleles by Tetra-Primer PCR and of the CYP2D6*5 Allele by Multiplex Long PCR

2000 • 159 citations

The karolinska cocktail for phenotyping of five human cytochrome P450 enzymes

2003 • 155 citations

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism

1993 • 146 citations

Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N -acetyltransferase-2, and xanthine oxidase with the ″Cooperstown cocktail”

2000 • 143 citations

Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo

2005 • 132 citations

Pharmacogenetics of the Cytochromes P450

2004 • 130 citations

Rank-Based Analyses of Linear Models UsingR

2005 • 96 citations

Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype

2006 • 95 citations

Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects

2004 • 88 citations

Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication

1998 • 79 citations

Genetic Variations and Haplotypes of CYP2C19 in a Japanese Population

2005 • 78 citations

Assessment of cytochrome P450 activity by a five‐drug cocktail approach

2001 • 73 citations

An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A)

2001 • 68 citations

Assessment of cytochrome P450 activity by a five-drug cocktail approach

2001 • 45 citations

Impact of CYP2D6 intermediate metabolizer alleles on single-dose desipramine pharmacokinetics

2004 • 40 citations

So Many Studies, Too Few Subjects: Establishing Functional Relevance of Genetic Polymorphisms on Pharmacokinetics

2006 • 28 citations

Significant Interactions between CYP Probes in A 6‐Drug Cocktail

2003 • 1 citations

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