Protein turnover of the lysosomal and mitochondrial fractions of rat liver during aging

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

1949 • 16,078 citations

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

1955 • 4,109 citations

Functions of Lysosomes

1966 • 2,942 citations

THE DETERMINATION OF INORGANIC PHOSPHATE IN THE PRESENCE OF LABILE PHOSPHATE ESTERS

1946 • 1,611 citations

A MICROSPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CYTOCHROME OXIDASE

1951 • 1,369 citations

THE ISOLATION AND PROPERTIES OF THE SPECIFIC CYTOPLASMIC GRANULES OF RABBIT POLYMORPHONUCLEAR LEUCOCYTES

1960 • 708 citations

GOLGI APPARATUS, GERL, AND LYSOSOMES OF NEURONS IN RAT DORSAL ROOT GANGLIA, STUDIED BY THICK SECTION AND THIN SECTION CYTOCHEMISTRY

1971 • 583 citations

Studies on the Synthesis and Degradation of Proteins of the Endoplasmic Reticulum of Rat Liver

1969 • 538 citations

CHROMOGENIC SUBSTRATES

1946 • 512 citations

The Biogenesis of Mitochondria

1970 • 505 citations

The Turnover of Mitochondria in a Variety of Tissues of Young Adult and Aged Rats

1971 • 335 citations

Enzyme synthesis and degradation in mammalian systems

1971 • 310 citations

Digestive Activity of Lysosomes

1968 • 254 citations

MORPHOLOGIC CHANGES ACCOMPANYING SENESCENCE OF CULTURED HUMAN DIPLOID CELLS

1970 • 239 citations

Size Distribution of Membrane Proteins of Rat Liver and Their Relative Rates of Degradation

1971 • 192 citations

The Kinetics of Disappearance of Labeled Leucine from the Free Leucine Pool and Rat Liver and Its Effect on the Apparent Turnover of Catalase and Other Hepatic Proteins

1971 • 158 citations

INTRACELLULAR DISTRIBUTION OF ENZYMES

1952 • 149 citations

Preparation of rat liver lysosomes

1967 • 147 citations

Aging in Cell and Tissue Culture

1970 • 146 citations

The effect of mutation on the intracellular location of β-glucuronidase

1961 • 146 citations

A rapid and simple procedure to deplete rat-liver mitochondria of lysosomal activity

1970 • 129 citations

β-Glucuronidase of Rat Liver Lysosomes

1971 • 129 citations

Protein synthesis by membrane-bound and free ribosomes of secretory and non-secretory tissues

1971 • 120 citations

Age-dependent effects in enzyme induction- a biochemical expression of aging

1971 • 118 citations

The effect of age on protein synthesis in mouse liver

1969 • 118 citations

Localization and Turnover Studies of Membrane Nicotinamide Adenine Dinucleotide Glycohydrolase in Rat Liver

1971 • 116 citations

Cytochrome c Oxidase Components

1963 • 111 citations

PASSAGE OF FUCOSE-3H LABEL FROM THE GOLGI APPARATUS INTO DENSE AND MULTIVESICULAR BODIES IN THE DUODENAL COLUMNAR CELLS AND HEPATOCYTES OF THE RAT

1971 • 86 citations

Protein synthesis in growing-rat tissues

1966 • 75 citations

Ultrastructural aspects of neutrophil granulocyte development in humans.

1970 • 74 citations

Changes in the ribonucleic acid metabolism of aging mouse tissues with particular reference to the prostate gland

1968 • 71 citations

Effect of Age on Oxidative Phosphorylation in the Rat

1968 • 66 citations

Polyribosome concentration of mouse skeletal muscle as a function of age

1969 • 57 citations

Degradation of Nucleic Acids by Lysosomal Extracts of Rat Liver and Ehrlich Ascites Tumor Cells

1970 • 45 citations

What determines the half-life of proteins in, vivo? Some experiences with alanine aminotransferase of rat tissues

1969 • 42 citations

Rat serum protein changes with age

1971 • 41 citations

Action of cathepsins C and D in protein hydrolysis

1971 • 41 citations

Mitochondrial studies in senescent mice—II. Specific activity, buoyant density, and turnover of mitochondrial DNA

1971 • 38 citations

Acid phosphatase activity during growth and synchronous division of Tetrahymena pyriformis W*1

1963 • 35 citations

The turnover of the protein of the inner and outer mitochondrial membrane of rat liver

1969 • 35 citations

Reappraisal of Biological Ageing

1970 • 34 citations

Incorporation of [14C]glucosamine and [14C]leucine into mouse kidney β-glucuronidase induced by gonadotrophin

1970 • 29 citations

Age-correlated changes in lysosomal enzyme activities: An index of ageing?

1969 • 28 citations

Ribonucleic Acid Synthesis by Nuclei Isolated From Rats of Different Ages

1970 • 26 citations

Hydrolase activity and intracellular pH in liver, heart and diaphragm of aging rats

1971 • 24 citations

Recovery from Zoxazolamine Paralysis and Metabolism in vitro of Zoxazolamine in Ageing Mice

1971 • 24 citations

Turnover of Liver Mitochondrial Components in Adult and Senescent Rats

1961 • 21 citations

Mitochondrial studies in senescent mice—I. Turnover of brain mitochondrial lipids

1971 • 12 citations

Changes in protease and ribonuclease activities in brain and liver during the life-span of the rat.

1969 • 9 citations

NADPH and ascorbate catalyzed peroxidation of microsomal lipids during ageing

1971 • 5 citations

RNA/protein ratios of canine pancreatic microsomes and their subfractions as a function of age

1971 • 5 citations