Drastic change in idiotypic but not antigen-binding specificity of an antibody by a single amino-acid substitution

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

1963 • 10,322 citations

A gas-liquid solid phase peptide and protein sequenator.

1981 • 2,238 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

1978 • 316 citations

Genetics, Expression, and Function of Idiotypes

1983 • 264 citations

Analysis of the repertoire of anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti‐idiotope antibodies

1979 • 254 citations

Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to alpha-(1 leads to 3) dextran.

1980 • 115 citations

Single amino acid substitution altering antigen-binding specificity.

1982 • 112 citations

Recombination between antibody heavy chain variable-region genes: evidence for gene conversion.

1983 • 104 citations

Structural basis for the specificity of antibody–antigen reactions and structural mechanisms for the diversification of antigen-binding specificities

1977 • 94 citations

Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.

1982 • 86 citations

Antigen-binding mutants of mouse myeloma cells.

1977 • 82 citations

Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line.

1981 • 78 citations

Somatic mutation in a cultured mouse myeloma cell affects antigen binding.

1982 • 76 citations

Monoclonal antibodies and T-cell hybridomas : perspectives and technical advances

1981 • 76 citations

The immune response against anti‐idiotope antibodies. I. Induction of idiotope‐bearing antibodies and analysis of the idiotope repertoire

1982 • 67 citations

Junctional diversity is essential to antibody activity.

1984 • 63 citations

Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity.

1982 • 52 citations

Molecular basis of an isogeneic anti-idiotypic response.

1984 • 51 citations

A biological consequence of variation in the site of D–JH gene rearrangement

1984 • 29 citations

The D segment defines the T15 idiotype: the immunoresponse of A/J mice to Pneumococcus pneumoniae

1984 • 28 citations

C-terminal sequence of the secreted form of mouse IgD heavy chain

1981 • 19 citations

Progress in immunology

1986 • 3 citations