The potential of melanoma antigen expression in cancer therapy

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

THE TREATMENT OF MALIGNAT TUMORS BY REPEATED INOCULATIONS OF ERYSIPELAS

1893 • 946 citations

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

1994 • 771 citations

A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

1992 • 694 citations

Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin.

1953 • 686 citations

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes

1995 • 598 citations

Structure, chromosomal localization, and expression of 12 genes of the MAGE family

1994 • 595 citations

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

1995 • 591 citations

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1996 • 552 citations

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

1976 • 478 citations

A peptide encoded by human gene MAGE‐3 and presented by HLA‐A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE‐3

1994 • 379 citations

Intradermal Immunization of C3H Mice against a Sarcoma That Originated in an Animal of the Same Line

1943 • 363 citations

Detection of occult melanoma cells in blood with a multiple-marker polymerase chain reaction assay.

1995 • 338 citations

Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells.

1995 • 324 citations

Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes.

1994 • 316 citations

Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptidesin vivo

1996 • 308 citations

Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.

1994 • 292 citations

Expression of MAGE genes in primary and metastatic cutaneous melanoma

1995 • 285 citations

Generation of cytotoxic T-cell responses with synthetic melanoma-associated peptidesin vivo: Implications for tumor vaccines with melanoma-associated antigens

1996 • 250 citations

Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601

1994 • 233 citations

Expression of mage genes by non‐small‐cell lung carcinomas

1994 • 230 citations

Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis.

1995 • 227 citations

Identification of a new MAGE gene with tumor-specific expression by representational difference analysis.

1998 • 184 citations

Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas.

1997 • 154 citations

Enhancement of cytolytic T lymphocyte precursor frequency in melanoma patients following immunization with the MAGE-1 peptide loaded antigen presenting cell-based vaccine.

1996 • 150 citations

Expression of mage genes in transitional‐cell carcinomas of the urinary bladder

1995 • 141 citations

Identification and intracellular location of MAGE-3 gene product.

1995 • 140 citations

Two Members of the HumanMAGEBGene Family Located in Xp21.3 Are Expressed in Tumors of Various Histological Origins

1997 • 139 citations

The Melanoma Antigen Gene (MAGE) Family Is Clustered in the Chromosomal Band Xq28

1995 • 121 citations

Phase I and pharmacokinetic study of 5-aza-2'-deoxycytidine (NSC 127716) in cancer patients.

1986 • 118 citations

Isolation and characterization of a MAGE gene family in the Xp21.3 region.

1995 • 106 citations

The expression of tumor-rejection antigen “MAGE” genes in human gastric carcinoma

1995 • 94 citations

Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease.

1997 • 84 citations

Pilot study of 5-aza-2'-deoxycytidine (Decitabine) in the treatment of poor prognosis acute myelogenous leukemia patients: preliminary results.

1993 • 84 citations

Expression of the mage gene family in primary and metastatic human breast cancer: Implications for tumor antigen‐specific immunotherapy

1995 • 78 citations

Melanoma patients immunized with melanoma cell vaccine induce antibody responses to recombinant MAGE-1 antigen.

1995 • 78 citations

Expression of MAGE Genes in Human Colorectal Carcinoma

1996 • 77 citations

The expression of mouse geneP1A in testis does not prevent safe induction of cytolytic T cells against a P1A-encoded tumor antigen

1997 • 76 citations

Second solid malignancies after combined modality therapy for Hodgkin's disease.

1995 • 71 citations

Expression of the MAGE gene family in human head‐and‐neck squamous‐cell carcinomas

1995 • 65 citations

Analysis of MAGE-3-specific cytolytic T lymphocytes in human leukocyte antigen-A2 melanoma patients.

1997 • 62 citations

MAGE‐1 gene product is a cytoplasmic protein

1994 • 61 citations

Expression of MAGE genes in osteosarcoma

1997 • 57 citations

High frequency of the MAGE-1 gene expression in hepatocellular carcinoma

1996 • 56 citations

Expression of MAGE-1, MAGE-3 and MART-1 genes in neuroblastoma

1996 • 54 citations

Identification of potential CTL epitopes of tumor-associated antigen MAGE-1 for five common HLA-A alleles

1994 • 54 citations

Human esophageal carcinomas frequently express the tumor-rejection antigens ofMAGE genes

1995 • 53 citations

MAGE-1-specific precursor cytotoxic T-lymphocytes present among tumor-infiltrating lymphocytes from a patient with breast cancer: characterization and antigen-specific activation.

1996 • 51 citations

Infrequent expression of the MAGE gene family in uveal melanomas

1996 • 50 citations

Methylated CpG points identified withinMAGE-1 promoter are involved in gene repression

1996 • 50 citations

Detection of mage‐4 protein in lung cancers

1995 • 50 citations

Expression of MAGE and BAGE genes in Japanese breast cancers

1997 • 48 citations

Teaching the Immune System to Fight Cancer

1993 • 47 citations

Expression of MAGE‐1, MAGE‐2, MAGE‐3/‐6 and MAGE‐4A/‐4B genes in ovarian tumors

1995 • 46 citations

A member of the melanoma antigen‐encoding gene (MAGE) family is expressed in human skin during wound healing

1994 • 44 citations

MAGE, BAGE and GAGE: tumour antigen expression in benign and malignant ovarian tissue

1998 • 43 citations

MAGE-1 andMAGE-3 or-6 expression in neuroblastoma-related pediatric solid tumors

1996 • 36 citations

Induction of MAGE Genes in Lymphoid Cells by the Demethylating Agent 5‐Aza‐2′‐deoxycytidine

1996 • 30 citations

Expression of the MAGE gene family in human lymphocytic leukemia

1995 • 30 citations

Expression of MAGE genes in esophageal squamous-cell carcinoma.

1997 • 28 citations

Definition of tumor antigens suitable for vaccine construction

1995 • 28 citations

Detection of MAGE-1 Tumor Antigen in Brain Tumor.

1997 • 27 citations

Monoclonal antibodies against recombinant-MAGE-1 protein identify a cross-reacting 72-kDa antigen which is co-expressed with MAGE-1 protein in melanoma cells

1996 • 26 citations

The tumour-associated antigen MAGE-1 is detectable in formalin-fixed paraffin sections of malignant melanoma

1996 • 26 citations

The Tumor Protein MAGE-1 Is Located in the Cytosol of Human Melanoma Cells

1994 • 25 citations

HLA Photoaffinity Labeling Reveals Overlapping Binding of Homologous Melanoma-associated Gene Peptides by HLA-A1, HLA-A29, and HLA-B44

1996 • 24 citations

Expression of MAGE Genes in Ocular Melanoma Cell Lines

1997 • 24 citations

Melanoma antigen-encoding gene-1 expression in invasive gastric carcinoma: Correlation with stage of disease

1997 • 23 citations

Molecular cytogenetic mapping of the human melanoma antigen (MAGE) gene family to chromosome region Xq27-qter: implications for MAGE immunotherapy.

1994 • 22 citations

Expression of MAGE‐1 Gene by Esophageal Carcinomas

1995 • 21 citations

Detection of MAGE-4 protein in sera of patients with head-and-neck squamous-cell carcinoma

1997 • 21 citations

Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens

1995 • 21 citations

Presentation of synthetic peptide antigen encoded by the MAGE-1 gene by granulocyte/macrophage-colony-stimulating-factor-cultured macrophages from HLA-A1 melanoma patients

1995 • 20 citations

Expression of the MAGE-1, -2, -3, -4, and -6 Genes in Non-Squamous Cell Carcinoma Lesions of the Head and Neck

1996 • 17 citations

Cloning and Analysis of MAGE-1-Related Genes

1994 • 16 citations

Expression of MAGE Gene Family in Lung Cancers.

1996 • 14 citations

Expression of genes MAGE-1, -2, and -3 by human maxillary carcinoma cells.

1995 • 10 citations

Detection of MAGE‐4 Protein in Sera of Lung Cancer Patients

1997 • 7 citations