Advantages and disadvantages of alpha2-adrenoceptor agonists for systemic hypertension

Presynaptic regulation of the release of catecholamines.

1980 • 1,483 citations

MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

1985 • 1,463 citations

Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors.

1977 • 544 citations

Cardiovascular Risk and Risk Factors in a Randomized Trial of Treatment Based on the Beta-Blocker Oxprenolol: The International Prospective Primary Prevention Study in Hypertension (IPPPSH)

1985 • 348 citations

Clinical pharmacology and pharmacokinetics of clonidine

1976 • 275 citations

Pharmacokinetics and concentration‐effect relationships of intravenous and oral clonidine

1977 • 260 citations

VIBRIO PARAHÆMOLYTICUS

1974 • 235 citations

Inhibition of adrenergic neurotransmission by clonidine: An action on prejunctional α-receptors

1973 • 225 citations

CLONIDINE WITHDRAWAL IN HYPERTENSION

1977 • 147 citations

The central hypotensive effect of clonidine; Studies in tetraplegie subjcets

1977 • 112 citations

Clonidine hydrochloride: Review of pharmacologic and clinical aspects

1981 • 99 citations

Pharmacokinetic and concentration-effect relationships of clonidine in essential hypertension

1977 • 94 citations

HEMODYNAMIC CHANGES AT REST AND DURING EXERCISE IN LONG‐TERM CLONIDINE THERAPY OF ESSENTIAL HYPERTENSION

1974 • 81 citations

Sedative and cardiovascular effects of clonidine and nitrazepam

1980 • 69 citations

Hemodynamic and vascular responses to antihypertensive treatment with adrenergic blocking agents: A review

1970 • 64 citations

The antihypertensive mechanism of clonidine in man. Evidence against a generalized reduction of sympathetic activity.

1981 • 50 citations

Apparent resistance to hypotensive effect of clonidine.

1977 • 44 citations

HAeMODYNAMIC STUDIES WITH METHYLDOPA: EFFECT ON CARDIAC OUTPUT AND RESPONSE TO PRESSOR AMINES

1963 • 43 citations

Clonidine and Sympathetic Activity during Sleep

1979 • 37 citations

Centrally acting drugs in antihypertensive therapy.

1980 • 28 citations

The effect of microelectrophoretically applied clonidine on single cerebral cortical neurones in the rat

1982 • 22 citations

Acute Effects of Alpha-Methyldopa on Mean Blood Pressure and Plasma Renin Activity

1974 • 21 citations

The clinical pharmacology of antihypertensive drugs.

1984 • 19 citations

Reduced renovascular resistance by clonidine

1979 • 16 citations

Guanfacine: Effects of long‐term treatment and withdrawal.

1980 • 15 citations

Sympathetic Nervous Function and Renin Activity in Hypertensives on Long Term Drug Treatment with Propranolol, Methyldopa or Bendrofluazide

1978 • 12 citations

Long-term clonidine effects on autonomic function in essential hypertensive man

1981 • 12 citations

Effect of alpha‐methyldopa on cardiac output in hypertension

1979 • 10 citations

Plasma cyclic nucleotides and plasma catecholamines before and after prolonged treatment with clonidine in hypertensive patients

1981 • 3 citations