The developing intestinal microbiome and its relationship to health and disease in the neonate

A core gut microbiome in obese and lean twins

2008 • 7,389 citations

The Human Microbiome Project

2007 • 5,410 citations

Hay fever, hygiene, and household size.

1989 • 4,910 citations

The gut microbiota shapes intestinal immune responses during health and disease

2009 • 4,497 citations

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

2010 • 4,105 citations

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

2004 • 4,044 citations

Development of the Human Infant Intestinal Microbiota

2007 • 2,714 citations

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

2010 • 2,643 citations

Commensal Host-Bacterial Relationships in the Gut

2001 • 2,278 citations

The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing

2008 • 2,252 citations

Factors Influencing the Composition of the Intestinal Microbiota in Early Infancy

2006 • 2,099 citations

Interactions between commensal intestinal bacteria and the immune system

2004 • 1,540 citations

Analysis of Intestinal Flora Development in Breast-Fed and Formula-Fed Infants by Using Molecular Identification and Detection Methods

2000 • 1,341 citations

Microbes in Gastrointestinal Health and Disease

2008 • 1,297 citations

Short-Term Antibiotic Treatment Has Differing Long-Term Impacts on the Human Throat and Gut Microbiome

2010 • 1,090 citations

The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction.

1997 • 1,088 citations

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells

2002 • 1,055 citations

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

2008 • 1,014 citations

Long-term ecological impacts of antibiotic administration on the human intestinal microbiota

2007 • 1,003 citations

Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR

2004 • 973 citations

Microbial community profiling for human microbiome projects: Tools, techniques, and challenges

2009 • 946 citations

DGGE/TGGE a method for identifying genes from natural ecosystems

1999 • 905 citations

Prolonged Duration of Initial Empirical Antibiotic Treatment Is Associated With Increased Rates of Necrotizing Enterocolitis and Death for Extremely Low Birth Weight Infants

2008 • 890 citations

Fecal Microflora in Healthy Infants Born by Different Methods of Delivery: Permanent Changes in Intestinal Flora After Cesarean Delivery

1999 • 874 citations

Microbial Prevalence, Diversity and Abundance in Amniotic Fluid During Preterm Labor: A Molecular and Culture-Based Investigation

2008 • 763 citations

Use of 16S rRNA Gene-Targeted Group-Specific Primers for Real-Time PCR Analysis of Predominant Bacteria in Human Feces

2004 • 640 citations

Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial

2007 • 586 citations

16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis

2009 • 560 citations

Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Neonates

2005 • 555 citations

Updated Meta-analysis of Probiotics for Preventing Necrotizing Enterocolitis in Preterm Neonates

2010 • 533 citations

Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Preterm Infants: A Multicenter, Randomized, Controlled Trial

2008 • 500 citations

Targeting the Human Microbiome With Antibiotics, Probiotics, and Prebiotics: Gastroenterology Enters the Metagenomics Era

2009 • 464 citations

Terminal restriction fragment length polymorphism (T-RFLP): An emerging method for characterizing diversity among homologous populations of amplification products

1999 • 463 citations

A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair

2007 • 444 citations

Cesarean Delivery May Affect the Early Biodiversity of Intestinal Bacteria1,

2008 • 416 citations

NICHD Neonatal Research Network

2002 • 389 citations

The Roles of Bacteria and TLR4 in Rat and Murine Models of Necrotizing Enterocolitis

2006 • 376 citations

Intestinal Microbial Ecology in Premature Infants Assessed with Non–Culture-Based Techniques

2009 • 358 citations

Dietary modulation of the human gut microflora using prebiotics

1998 • 321 citations

Probiotics in the prevention of antibiotic-associated diarrhea in children: A meta-analysis of randomized controlled trials

2006 • 316 citations

Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children

2010 • 310 citations

99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Darwinian medicine and the ‘hygiene’ or ‘old friends’ hypothesis

2010 • 304 citations

Alive and Dead Lactobacillus rhamnosus GG Decrease Tumor Necrosis Factor-α–Induced Interleukin-8 Production in Caco-2 Cells

2005 • 287 citations

An Invitation to the Marriage of Metagenomics and Metabolomics

2008 • 263 citations

Coordination of tolerogenic immune responses by the commensal microbiota

2009 • 249 citations

Is delivery by cesarean section a risk factor for food allergy?

2003 • 247 citations

Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota

2010 • 201 citations

Factors controlling the bacterial colonization of the intestine in breastfed infants

1999 • 200 citations

Isotypes and specificities of immunoglobulins produced by germ‐free mice fed chemically defined ultrafiltered “antigen‐free” diet

1984 • 194 citations

Mode of delivery and development of atopic disease during the first 2 years of life

2004 • 194 citations

Effects of intestinal microflora and the environment on the development of asthma and allergy

2004 • 188 citations

Immunomodulation by Commensal and Probiotic Bacteria

2010 • 182 citations

Probiotics in Gastrointestinal Diseases in Children

2006 • 167 citations

Microbial Colonization Drives Lymphocyte Accumulation and Differentiation in the Follicle-Associated Epithelium of Peyer’s Patches

2003 • 157 citations

Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine

2008 • 143 citations

Caesarean section and gastrointestinal symptoms, atopic dermatitis, and sensitisation during the first year of life

2004 • 141 citations

Live and Heat-Killed Lactobacillus rhamnosus GG: Effects on Proinflammatory and Anti-Inflammatory Cytokines/Chemokines in Gastrostomy-Fed Infant Rats

2009 • 132 citations

Live and Ultraviolet-Inactivated Lactobacillus Rhamnosus GG Decrease Flagellin-Induced Interleukin-8 Production in Caco-2 Cells

2008 • 106 citations

Epithelial Cells and Their Neighbors. IV. Bacterial contributions to intestinal epithelial barrier integrity

2005 • 98 citations

Intestinal microbiota development in the premature neonate: establishment of a lasting commensal relationship?

2008 • 81 citations

Childhood asthma hospitalization risk after cesarean delivery in former term and premature infants

2005 • 73 citations

A roadmap for understanding and preventing necrotizing enterocolitis

2008 • 68 citations

Potential Roles and Clinical Utility of Prebiotics in Newborns, Infants, and Children: Proceedings from a Global Prebiotic Summit Meeting, New York City, June 27-28, 2008

2009 • 68 citations

Lactobacillus rhamnosus GG Decreases Lipopolysaccharide‐induced Systemic Inflammation in a Gastrostomy‐fed Infant Rat Model

2006 • 50 citations

Developmental factors associated with risk for atopic disease: implications for vaccine strategies in early childhood

2003 • 25 citations

Gut Microbiota: Metagenomics to Study Complex Ecology

2010 • 17 citations