Chronic diazepam treatment produces regionally specific changes in GABA-stimulated chloride influx

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Benzodiazepine/GABA Receptors and Chloride Channels: Structural and Functional Properties.

1987 • 368 citations

The benzodiazepines: from molecular biology to clinical practice

1984 • 293 citations

The GABA-Ergic System: A Locus of Benzodiazepine Action

1985 • 291 citations

Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity

1984 • 279 citations

Functional Coupling of γ-Aminobutyric Acid Receptors to Chloride Channels in Brain Membranes

1985 • 270 citations

Benzodiazepine/GABA receptors and chloride channels : structural and functional properties

1986 • 260 citations

Chronic benzodiazepine administration. I. Tolerance is associated with benzodiazepine receptor downregulation and decreased gamma-aminobutyric acidA receptor function.

1988 • 211 citations

Tolerance to the behavioral actions of benzodiazepines

1985 • 200 citations

Tolerance during chronic benzodiazepine treatment associated with decreased receptor binding

1981 • 133 citations

Continuous release of diazepam: Electrophysiological, biochemical and behavioral consequences

1985 • 105 citations

The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma

1986 • 103 citations

Biochemical identification of pharmacologically and functionally distinct GABA receptors in rat brain

1981 • 97 citations

Chronic clonazepam administration induced benzodiazepine receptor subsensitivity

1982 • 91 citations

Characterization of the Binding of [³H]SR 95531, a GABA_A Antagonist, to Rat Brain Membranes

1987 • 91 citations

Benzodiazepine Enhancement of γ‐Aminobutyric Acid‐Mediated Chloride Ion Flux in Rat Brain Synaptoneurosomes

1988 • 86 citations

The effect of benzodiazepines and β-carbolines on gabastimulated chloride influx by membrane vesicles from the rat cerebral cortex

1986 • 86 citations

Tolerance to the benzodiazepine diazepam in an animal model of anxiolytic activity

1985 • 86 citations

Time course for development of benzodiazepine tolerance and physical dependence

1985 • 85 citations

Experimental induction of benzodiazepine tolerance and physical dependence.

1983 • 85 citations

Time course for development of anticonvulsant tolerance and GABAergic subsensitivity after chronic diazepam

1987 • 65 citations

Biochemical pharmacology of the gamma-aminobutyric acid receptor/ionophore protein.

1984 • 59 citations

Modulation of GABA-gated chloride ion flux in rat brain by acute and chronic benzodiazepine administration.

1988 • 51 citations

Functional tolerance to lorazepam in the rat

1983 • 47 citations

Long-term administration of benzodiazepines: pharmacokinetic versus pharmacodynamic tolerance.

1986 • 41 citations

Can benzodiazepines be classified by characterising their anticonvulsant tolerance-inducing potential?

1988 • 35 citations

Continuous slow release of low levels of diazepam produces tolerance to its depressant and anxiolytic effects on the startle reflex

1988 • 34 citations

Comparison of norepinephrine- and benzodiazepine-induced augmentation of Purkinje cell responses to gamma-aminobutyric acid (GABA).

1984 • 34 citations

Effects of chronic diazepam exposure on GABA sensitivity and on benzodiazepine potentiation of GABA-mediated responses of substantia nigra pars reticulata neurons of rats

1987 • 32 citations

Benzodiazepine and β-carboline modulation of GABA-stimulated 36Cl-influx in cultured spinal cord neurons

1987 • 29 citations

Pharmacokinetic Properties of Benzodiazepine Hypnotics

1983 • 27 citations

Tolerance to the anticonvulsant effect of clonazepam in mice: no concurrent change in plasma concentration

1986 • 21 citations

Decrease in [3H]flunitrazepam receptor binding in rats tolerant to the effects of nitrazepam

1988 • 10 citations

Chronic benzodiazepine agonist exposure: comparison of electrophysiological changes by brain region and benzodiazepine receptor ligand.

1988 • 7 citations