Cytokine regulation of granuloma formation in schistosomiasis

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni.

1991 • 777 citations

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

1990 • 679 citations

Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni.

1991 • 542 citations

Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice

1992 • 424 citations

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

1995 • 403 citations

Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity.

1967 • 340 citations

Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni.

1993 • 337 citations

Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.

1991 • 312 citations

Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets.

1994 • 299 citations

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

1994 • 276 citations

Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology.

1994 • 274 citations

Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.

1994 • 234 citations

Host response to eggs of S. mansoni. I. Granuloma formation in the unsensitized laboratory mouse.

1962 • 189 citations

CD4+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage.

1992 • 171 citations

Anti-L3T4 antibody treatment suppresses hepatic granuloma formation and abrogates antigen-induced interleukin-2 production in Schistosoma mansoni infection

1986 • 160 citations

IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production.

1990 • 155 citations

Immunology and Molecular Biology of Parasitic Infections

1993 • 151 citations

Role of IL-4 and IFN-gamma in Schistosoma mansoni egg-induced hypersensitivity granuloma formation. Orchestration, relative contribution, and relationship to macrophage function.

1992 • 149 citations

Inflammatory granuloma formation is mediated by TNF-alpha-inducible intercellular adhesion molecule-1.

1994 • 137 citations

IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma.

1995 • 131 citations

The role of macrophage inflammatory protein 1 alpha in Schistosoma mansoni egg-induced granulomatous inflammation.

1993 • 126 citations

IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni.

1994 • 109 citations

Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice

1993 • 97 citations

Tumor necrosis factor plays a role in Schistosoma mansoni egg-induced granulomatous inflammation.

1993 • 97 citations

Regulation of T helper cell responses in experimental murine schistosomiasis by IL-10. Effect on expression of B7 and B7-2 costimulatory molecules by macrophages.

1994 • 96 citations

Lymphokine Regulation of Granuloma Formation in Murine Schistosomiasis Mansoni

1993 • 90 citations

IL-4 influences IL-2 production and granulomatous inflammation in murine schistosomiasis mansoni.

1992 • 77 citations

Monocyte chemotactic protein expression during schistosome egg granuloma formation. Sequence of production, localization, contribution, and regulation.

1995 • 75 citations

Cross-regulatory role of interferon-gamma (IFN-γ), IL-4 and IL-10 in schistosome egg granuloma formation:in vivoregulation of Th activity and inflammation

1994 • 72 citations

Evolving T cell responses in murine schistosomiasis. Th2 cells mediate secondary granulomatous hypersensitivity and are regulated by CD8+ T cells in vivo.

1993 • 69 citations

Substance P modulates antigen-induced, IFN-gamma production in murine Schistosomiasis mansoni.

1993 • 69 citations

Two distinct pathological syndromes in male CBA/J inbred mice with chronic Schistosoma mansoni infections.

1993 • 68 citations

Treatment with anti-IL-2 antibodies reduces hepatic pathology and eosinophilia in Schistosoma mansoni-infected mice while selectively inhibiting T cell IL-5 production.

1992 • 58 citations

In vivo molecular analysis of lymphokines involved in the murine immune response during Schistosoma mansoni infection. II. Quantification of IL-4 mRNA, IFN-gamma mRNA, and IL-2 mRNA levels in the granulomatous livers, mesenteric lymph nodes, and spleens during the course of modulation.

1992 • 57 citations

Macrophages from schistosomal egg granulomas induce unresponsiveness in specific cloned Th-1 lymphocytes in vitro and down-regulate schistosomal granulomatous disease in vivo.

1994 • 57 citations

Role of IL-10 on antigen-presenting cell function for schistosomal egg-specific monoclonal T helper cell responses in vitro and in vivo.

1993 • 52 citations

The cell-mediated response to schistosomal antigens at the clonal level. In vivo functions of cloned murine egg antigen-specific CD4+ T helper type 1 lymphocytes.

1991 • 51 citations

Immunopathology of Schistosoma japonicum and S. mansoni infection in B cell depleted mice

1985 • 46 citations

Recombinant IL-2 therapy reverses diminished granulomatous responsiveness in anti-L3T4-treated, Schistosoma mansoni-infected mice.

1990 • 45 citations

Anti‐interleukin‐4 treatment diminishes secretion of Th2 cytokines and inhibits hepatic fibrosis in murine schistosomiasis japonica

1995 • 36 citations

Eosinophil Chemotactic Factor in Schistosome Eggs: A Comparative Study of Eosinophil Chemotactic Factors in the Eggs of Schistosoma Japonicum and S. Mansoni in Vitro

1983 • 35 citations

Soluble intercellular adhesion molecules in human schistosomiasis: correlations with disease severity and decreased responsiveness to egg antigens

1994 • 31 citations

Cloning of TH0- and TH2-type helper lymphocytes from liver granulomas of Schistosoma mansoni-infected mice

1994 • 27 citations

Flow-cytometric evaluation of lymphocyte subpopulations in synchronously developing Schistosoma mansoni egg and Sephadex bead pulmonary granulomas.

1988 • 25 citations

Immune responses during human Schistosoma mansoni. XVII. Recognition by monoclonal anti-idiotypic antibodies of several idiotopes on a monoclonal anti-soluble schistosomal egg antigen antibody and anti-soluble schistosomal egg antigen antibodies from patients with different clinical forms of infection.

1990 • 23 citations

In Vitro Granuloma Formation Using Defined Antigenic Nidi^a

1986 • 20 citations

Role of oxygen reactive species in Schistosoma mansoni egg-induced granulomatous inflammation

1984 • 19 citations

Granulomatous hypersensitivity to Schistosoma mansoni EGG antigens in human schistosomiasis. IV. A role for prostaglandin‐induced inhibition of in vitro granuloma formation

1994 • 17 citations

Linked in vivo expression of soluble interleukin‐4 receptor and interleukin‐4 in murine schistosomiasis

1995 • 16 citations

The Shrinking Schistosomal Egg Granuloma: How Accessory Cells Control T Cell-Mediated Pathology

1994 • 15 citations

Schistosoma japonicum-infected mice show reduced hepatic fibrosis and eosinophilia and selective inhibition of interleukin-5 secretion by CD4+ cells after treatment with anti-interleukin-2 antibodies

1993 • 12 citations

Characterization of a family of monoclonal antibodies which bind Schistosoma japonicum egg antigens and express an interstrain cross‐reactive idiotype

1990 • 5 citations

Deleted Work

1955 • 0 citations