Destruction of highly purified cytochromes P-450 associated with metabolism of fluorinated ether anesthetics

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Preparation and Properties of Partially Purified Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome P-450 Reductase from Rabbit Liver Microsomes

1974 • 518 citations

Cytochrome P-450 and its Role in Drug Metabolism

1972 • 392 citations

Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.

1977 • 367 citations

Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.

1976 • 316 citations

Separation and purification of multiple forms of microsomal cytochrome P-450. Partial characterization of three apparently homogeneous cytochromes P-450 prepared from livers of phenobarbital- and 3-methylcholanthrene-treated rats

1978 • 255 citations

Drugs and Enzyme Induction

1969 • 238 citations

Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide

1971 • 184 citations

Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates.

1980 • 178 citations

Destruction of heme and hemoproteins mediated by liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase

1978 • 139 citations

Immunological comparison of hepatic and extrahepatic cytochromes P-450.

1979 • 135 citations

The biotransformation of allyl alcohol and acrolein in rat liver and lung preparations.

1980 • 107 citations

Rat and human liver microsomal epoxide hydratase. Purification and evidence for the existence of multiple forms.

1979 • 105 citations

Studies of the metabolism of diethyl p-nitrophenyl phosphorothionate (parathion) and benzphetamine using an apparently homogeneous preparation of rat liver cytochrome P-450: effect of a cytochrome P-450 antibody preparation.

1976 • 79 citations

Accessibility of cytochrome P450 in microsomal membranes: inhibition of metabolism by antibodies to cytochrome P450.

1977 • 75 citations

Comparison of different forms of purified cytochrome P-450 from rat liver by immunological inhibition of regio- and stereoselective metabolism of warfarin.

1980 • 72 citations

Metabolism of vinyl chloride: destruction of the heme of highly purified liver Microsomal cytochrome P-450 by a metabolite.

1977 • 62 citations

Destruction of Cytochrome P ₄₅₀ by Secobarbital and Other Barbiturates Containing Allyl Groups

1972 • 49 citations

Comparison of different forms of liver, kidney, and lung microsomal cytochrome P-450 by immunological inhibition of regio- and stereoselective metabolism of warfarin.

1979 • 46 citations

Inhibition, activation, destruction, and induction of drug-metabolizing enzymes by trichloroethylene

1979 • 41 citations

Fluroxene (2,2,2-trifluoroethyl vinyl ether) mediated destruction of cytochrome P-450 in vitro

1975 • 41 citations

Inactivation of hepatic cytochrome P-450 by allenic substrates

1980 • 35 citations

Organic compounds. Their interaction with and degradation of hepatic microsomal drug-metabolizing enzymes in vitro.

1978 • 35 citations

Fluoroalkyl- and 3-(Fluoroalkoxy)propylpolysiloxanes

1961 • 32 citations

The Preparation and Properties of Some Vinyl and Glycidyl Fluoroethers

1957 • 31 citations

Further investigations of the metabolism of fluroxene and the degradation of cytochromes p-450 in vitro

1977 • 29 citations

The degradation of different forms of cytochrome P-450 in vivo by fluroxene and allyl-iso-propylacetamide

1978 • 26 citations

Inhibition of NADPH-cytochrome P450 reductase by cyclophosphamide and its metabolites

1981 • 22 citations

Enzymic modification of environmental intoxicants: the role of cytochrome P–450

1978 • 19 citations

The role of cytochrome P-450-inducing agents in potentiating the toxicity of fluroxene (2,2,2-trifluoroethyl vinyl ether)

1980 • 19 citations

Potentiation of fluroxene (2,2,2-trifluoroethyl vinyl ether) toxicity with polychlorinated biphenyls

1979 • 15 citations

Role of hepatic microsomal cytochrome P-450 in the toxicity of fluorinated ether anesthetics

1980 • 9 citations