Biochemical Reaction Products of Nitric Oxide as Quantitative Markers of Primary Pulmonary Hypertension

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Survival in Patients with Primary Pulmonary Hypertension

1991 • 3,369 citations

Primary Pulmonary Hypertension

1987 • 2,027 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

Primary Pulmonary Hypertension

1997 • 1,748 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension

1996 • 1,131 citations

Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension

1991 • 1,062 citations

Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

1991 • 983 citations

Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans

1991 • 960 citations

The biology of nitrogen oxides in the airways.

1994 • 928 citations

Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants with Hypoxic Respiratory Failure

1997 • 837 citations

Nitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization

1993 • 825 citations

Normal alveolar epithelial lining fluid contains high levels of glutathione

1987 • 795 citations

Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn

1997 • 787 citations

Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.

1995 • 770 citations

Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension.

1994 • 769 citations

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

1997 • 680 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Appetite-suppressant drugs and the risk of primary pulmonary hypertension

1997 • 582 citations

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

1994 • 518 citations

Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.

1995 • 517 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress.

1983 • 463 citations

Nitric oxide and lung disease.

1993 • 445 citations

Survival in primary pulmonary hypertension. Validation of a prognostic equation.

1994 • 368 citations

Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism.

1998 • 311 citations

Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms

1996 • 288 citations

Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen.

1995 • 204 citations

Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.

1997 • 186 citations

Identification of the subcellular site for nitroglycerin metabolism to nitric oxide in bovine coronary smooth muscle cells.

1990 • 177 citations

Fatal Pulmonary Hypertension Associated with Short-Term Use of Fenfluramine and Phentermine

1997 • 172 citations

Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide.

1996 • 165 citations

Increased Levels of Glutathione in Bronchoalveolar Lavage Fluid from Patients with Asthma

1993 • 161 citations

Role of Nitric Oxide in the Local Regulation of Pulmonary Vascular Resistance in Humans

1996 • 156 citations

Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans

1996 • 155 citations

Decreased Cu,Zn-SOD activity in asthmatic airway epithelium: correction by inhaled corticosteroid in vivo

1997 • 144 citations

Vascular remodeling in primary pulmonary hypertension. Potential role for transforming growth factor-beta.

1994 • 142 citations

Upregulation of Nitric Oxide Synthase Correlates Temporally With Onset of Pulmonary Vascular Remodeling in the Hypoxic Rat

1996 • 131 citations

H2O2 and endothelium-dependent cerebral arteriolar dilation. Implications for the identity of endothelium-derived relaxing factor generated by acetylcholine.

1990 • 113 citations

Chemical Engineer'S Handbook 3rd ed.

1950 • 103 citations

Glutathione and inflammatory disorders of the lung

1991 • 88 citations

In vivo antioxidant gene expression in human airway epithelium of normal individuals exposed to 100% O2

1993 • 78 citations

Intravenous Morphine Increases Release of Nitric Oxide From Spinal Cord by an α-Adrenergic and Cholinergic Mechanism

1997 • 77 citations

Exhaled Nitric Oxide During Exercise in Primary Pulmonary Hypertension and Pulmonary Fibrosis

1997 • 75 citations

Significance of Glutathione in Lung Disease and Implications for Therapy

1994 • 73 citations

Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow

1996 • 69 citations

Alzheimer's disease. A radical vascular connection.

1996 • 56 citations

Mixed expired nitric oxide in primary pulmonary hypertension in relation to lung diffusion capacity

1994 • 47 citations

Active macrophage-associated TGF-beta co-localizes with type I procollagen gene expression in atherosclerotic human pulmonary arteries.

1995 • 40 citations

Appetite-suppressant drugs and the risk of primary pulmonary hypertension

1997 • 15 citations