Critical role of Toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

Toll-like receptors in innate immunity

2004 • 3,233 citations

Endogenous ligands of Toll-like receptors

2004 • 689 citations

Toll-Like Receptors: Linking Innate and Adaptive Immunity

2005 • 666 citations

Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses

2002 • 617 citations

Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB

2004 • 609 citations

Oxidative stress in viral and alcoholic hepatitis

2002 • 431 citations

Toll-Like Receptor Signaling Inhibits Hepatitis B Virus Replication In Vivo

2005 • 423 citations

Mitochondria in Steatohepatitis

2001 • 404 citations

Prospective study of bacterial infection in acute liver failure: An analysis of fifty patients

1990 • 332 citations

Cytokine regulation of liver injury and repair

2000 • 296 citations

Cytokines and Alcoholic Liver Disease

1993 • 292 citations

Oxidative stress and antioxidant defenses in ethanol-induced cell injury

2004 • 240 citations

Cytokines in the liver

2001 • 228 citations

Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin

1998 • 214 citations

Propionibacterium acnes treatment diminishes CD4+ NK1.1+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells.

1997 • 208 citations

Innate Immune Responses of Human Neonatal Cells to Bacteria from the Normal Gastrointestinal Flora

2002 • 208 citations

Fungal infection: a common, unrecognised complication of acute liver failure

1991 • 205 citations

Requirement of Heat Shock Protein 90 for Human Hepatitis B Virus Reverse Transcriptase Function

2004 • 179 citations

Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis

2005 • 179 citations

Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration

2005 • 162 citations

Adaptor usage and Toll‐like receptor signaling specificity

2005 • 157 citations

Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

2005 • 148 citations

Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice.

1998 • 145 citations

Cutting Edge: Myeloid Differentiation Factor 88 Deficiency Improves Resistance Against Sepsis Caused by Polymicrobial Infection

2002 • 138 citations

Insights in the Pathogenic Potential of Propionibacterium acnes From Its Complete Genome

2005 • 121 citations

Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production.

1999 • 116 citations

Interferon-γ activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells

2005 • 115 citations

Requirement for TLR9 in the Immunomodulatory Activity of Propionibacterium acnes

2005 • 112 citations

A pivotal role of IL-12 in T^h1-dependent mouse liver injury

1996 • 101 citations

Alleviation of Lipopolysaccharide-Induced Acute Liver Injury inPropionibacterium acnes-Primed IFN-γ-Deficient Mice by a Concomitant Reduction of TNF-α, IL-12, and IL-18 Production

1999 • 98 citations

Toll‐like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat‐inactivated E. coli

2005 • 93 citations

Cytokines and Liver Diseases

2001 • 88 citations

Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection.

2001 • 88 citations

Human herpesvirus-6 and acute liver failure1

2003 • 87 citations

Contribution of Toll-like Receptor 9 Signaling to the Acute Inflammatory Response to Nonviral Vectors

2004 • 83 citations

Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis

1997 • 81 citations

Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands byP. acnes involves up-regulation of MD-2 in mice

2004 • 62 citations

LIPOPOLYSACCHARIDE-INDUCED OXIDATIVE STRESS IN THE LIVER

1999 • 51 citations

Exacerbation of Granuloma Formation in IL-1 Receptor Antagonist-Deficient Mice with Impaired Dendritic Cell Maturation Associated with Th2 Cytokine Production

2005 • 36 citations

Type 1 interferon augments DNA‐based vaccination against hepatitis C virus core protein

2004 • 36 citations

The resistance of P. acnes -primed interferon γ-deficient mice to low-dose lipopolysaccharide-induced acute liver injury

2002 • 33 citations

Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury byPropioni- bacterium acnes

2005 • 31 citations

Recruitment of dendritic cells to pathological niches in inflamed liver

2005 • 31 citations

Metallothionein and Heat Shock Protein Expression during Acute Liver Injury and Regeneration in Rats

2000 • 28 citations

Expression and role of CD14 in mice sensitized to lipopolysaccharide by Propionibacterium acnes

2002 • 16 citations

Roles of CD14 in LPS-induced liver injury and lethality in mice pretreated with Propionibacterium acnes

2004 • 13 citations

Enhanced resistance to Gram-positive bacterium and increased susceptibility to bacterial endotoxin in mice sensitized withPropionibacterium acnes: involvement of Toll-like receptor

2004 • 9 citations

Prospects for hepatitis C vaccine.

2004 • 8 citations