Mutagenic activity of halogenated propanes and propenes: effect of bromine and chlorine positioning

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity

1986 • 208 citations

Renal processing of glutathione conjugates

1984 • 171 citations

Mutagenicity of 2‐ and 3‐carbon halogenated compounds in the salmonella/mammalian‐microsome test

1980 • 98 citations

Mutagenic potency of haloacroleins and related compounds

1980 • 78 citations

Metabolic activation of 2,4-diaminoanisole, a hair-dye component—I

1977 • 67 citations

The mutagenicity of halogenated alkanols and their phosphoric acid esters for Salmonella typhimurium

1979 • 64 citations

The metabolism of the soil fumigant 1,2-dibromo-3-chloropropane in the rat

1979 • 55 citations

Effect of bromine and chlorine positioning in the induction of renal and testicular toxicity by halogenated propanes

1991 • 48 citations

Metabolic activation of 1,2-dibromo-3-chloropropane: evidence for the formation of reactive episulfonium ion intermediates

1990 • 46 citations

Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes.

1990 • 43 citations

Mechanism of nephrotoxic action due to organohalogenated compounds

1989 • 40 citations

Dominant lethal studies in rats with 1,2-dibromo-3-chloropropane and its structurally related compounds

1982 • 38 citations

Testicular necrosis and DNA damage caused by deuterated and methylated analogs of 1,2-dibromo-3-chloropropane in the rat

1988 • 38 citations

Species differences in testicular necrosis and DNA damage, distribution and metabolism of 1,2-dibromo-3-chloropropane (DBCP)

1989 • 33 citations

Different mechanisms are involved in DNA damage, bacterial mutagenicity and cytotoxicity induced by 1,2-dibromo-3-chloropropane in suspensions of rat liver cells

1989 • 30 citations

The role of oxidative and conjugative pathways in the activation of 1,2-dibromo-3-chloropropane to DNA-damaging products in rat testicular cells.

1988 • 30 citations

Detection and mechanism of formation of the potent direct-acting mutagen 2-bromoacrolein from 1,2-dibromo-3-chloropropane

1988 • 30 citations

Renal necrosis and DNA damage caused by selectively deuterated and methylated analogs of 1,2-dibromo-3-chloropropane in the rat

1987 • 29 citations

Metabolic activation of 1,2-dibromo-3-chloropropane to mutagenic metabolites: detection and mechanism of formation of (Z)- and (E)-2-chloro-3-(bromomethyl) oxirane

1990 • 22 citations

Rat liver microsomal metabolism of propyl halides.

1982 • 22 citations

Synthesis and mutagenicity of selectively methylated analogs of tris(2,3-dibromopropyl)phosphate and 1,2-dibromo-3-chloropropane

1987 • 22 citations

Biotransformation of 1,2-dibromopropane in rats into four mercapturic acid derivatives.

1986 • 21 citations

Tissue levels of glutathione following acute inhalation of 1,3‐dichloropropene

1988 • 20 citations

Disposition of 1,2,3-trichloropropane in the fischer 344 rat: Conventional and physiological pharmacokinetics

1984 • 19 citations

Role of P-450 activity and glutathione levels in 1,2-dibromo-3-chloropropane tissue distribution, renal necrosis and in vivo DNA damage

1989 • 19 citations

Metabolism of 1,3-dibromopropane

1981 • 18 citations

Species Differences in Kidney Necrosis and DNA Damage, Distribution and Glutathione‐Dependent Metabolism of 1,2‐Dibromo‐3‐chloropropane (DBCP)

1990 • 17 citations

Metabolism of 2,3-dichloro-1-propene in the rat. Consideration of bioactivation mechanisms.

1988 • 17 citations

Mutagen activation of 1,2‐dibromo‐3‐chloropropane by cytosolic glutathione s‐transferases and microsomal enzymes

1986 • 15 citations

The role of biotransformation in the genotoxicity of allylic compounds

1987 • 12 citations

Genotoxicity of allyl compounds—A quick screening strategy based on structure-activity relationships and a battery of prescreening tests

1986 • 10 citations

The metabolism of 1,3-dibromopropane by the rat

1981 • 9 citations

Metabolism of selectively methylated and deuterated analogs of 1,2-dibromo-3-chloropropane: Role in organ toxicity and mutagenicity

1989 • 8 citations