Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents

In vivo imaging of tumors with protease-activated near-infrared fluorescent probes

1999 • 1,578 citations

Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

In vivo molecular target assessment of matrix metalloproteinase inhibition

2001 • 730 citations

Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands

2001 • 523 citations

Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation

2001 • 482 citations

In vivo near-infrared fluorescence imaging of osteoblastic activity

2001 • 371 citations

Developments Toward Diagnostic Breast Cancer Imaging Using Near-Infrared Optical Measurements and Fluorescent Contrast Agents1

2000 • 345 citations

Frequency-domain techniques enhance optical mammography: Initial clinical results

1997 • 338 citations

Novel Receptor-Targeted Fluorescent Contrast Agents for In Vivo Tumor Imaging

2000 • 315 citations

Near-Infrared Optical Imaging of Protease Activity for Tumor Detection

1999 • 311 citations

Fluorescence lifetime imaging in turbid media

1996 • 290 citations

Targeting by affinity–matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform

1997 • 289 citations

Development of a time-domain optical mammograph and first in vivo applications

1999 • 283 citations

Clinical optical tomography and NIR spectroscopy for breast cancer detection

1999 • 246 citations

Preparation of a Cathepsin D Sensitive Near-Infrared Fluorescence Probe for Imaging

1999 • 215 citations

Imaging of Spontaneous Canine Mammary Tumors Using Fluorescent Contrast Agents

1999 • 198 citations

Enhanced Optical Imaging of Human Gliomas and Tumor Margins

1996 • 183 citations

Imaging of fluorescent yield and lifetime from multiply scattered light reemitted from random media

1997 • 170 citations

Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform

2001 • 166 citations

Frequency-domain fluorescent diffusion tomography: a finite-element-based algorithm and simulations

1998 • 164 citations

Pharmacokinetics of ICG and HPPH-car for the Detection of Normal and Tumor Tissue Using Fluorescence, Near-infrared Reflectance Imaging: A Case Study¶

2000 • 163 citations

Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue

1999 • 144 citations

Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: Near-infrared fluorescence tomography

2002 • 136 citations

Synthesis, In Vitro Receptor Binding, and In Vivo Evaluation of Fluorescein and Carbocyanine Peptide-Based Optical Contrast Agents

2002 • 129 citations

Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carcinoma in nude mice.

1994 • 126 citations

Epidermal growth factor receptor-targeted immunophotodiagnosis and photoimmunotherapy of oral precancer in vivo.

2001 • 122 citations

Tumor labeling in vivo using cyanine-conjugated monoclonal antibodies

1995 • 109 citations

Immunophotodiagnosis of colon carcinomas in patients injected with fluoresceinated chimeric antibodies against carcinoembryonic antigen.

1992 • 104 citations

Macromolecular Contrast Agents for Optical Imaging of Tumors: Comparison of Indotricarbocyanine-labeled Human Serum Albumin and Transferrin¶

2000 • 94 citations

Antibody–fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice

1991 • 84 citations

Biomedical optical tomography using dynamic parameterization and Bayesian conditioning on photon migration measurements

1999 • 81 citations

Origin of phosphorescence signals reemitted from tissues

1994 • 77 citations

Three-dimensional fluorescence enhanced optical tomography using referenced frequency-domain photon migration measurements at emission and excitation wavelengths

2002 • 70 citations

Three-dimensional unconstrained and constrained image-reconstruction techniques applied to fluorescence, frequency-domain photon migration

2001 • 67 citations

Receptor imaging: Competitive or complementary to antibody imaging?

1997 • 57 citations

Near-infrared fluorescent dyes for enhanced contrast in optical mammography: phantom experiments

2001 • 56 citations

Active constrained truncated Newton method for simple-bound optical tomography

2000 • 43 citations

Enhanced Optical Imaging of Rat Gliomas and Tumor Margins

1994 • 42 citations

Truncated Newton's optimization scheme for absorption and fluorescence optical tomography: Part II Reconstruction from synthetic measurements

1999 • 41 citations

A numerical study of gradient-based nonlinear optimization methods for contrast enhanced optical tomography

2001 • 40 citations

Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II

1997 • 37 citations

Noninvasive optical imaging of the subarachnoid space and cerebrospinal fluid pathways based on near-infrared fluorescence

1997 • 36 citations

Error consideration in contrast-enhanced three-dimensional optical tomography

2001 • 28 citations

Improved reconstruction algorithm for luminescence optical tomography when background lumiphore is present

1998 • 23 citations

<title>Use of phosphorescent and fluorescent dyes for lifetime-based imaging within tissues</title>

1997 • 4 citations