Effects of Metal Binding on Protein Structure

Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery

1970 • 2,874 citations

Carp Muscle Calcium-binding Protein

1973 • 1,359 citations

Vitamin D-dependent Calcium-binding Protein

1968 • 484 citations

Structure of concanavalin A at 2.4-Ang resolution

1972 • 477 citations

Mechanism of Activation of a Cyclic Adenosine 3′:5′-Monophosphate Phosphodiesterase from Bovine Heart by Calcium Ions

1973 • 444 citations

Oxygenation of hemoglobin in the presence of 2,3-diphosphoglycerate. Effect of temperature, pH, ionic strength, and hemoglobin concentration

1969 • 402 citations

Carboxypeptidase A: A Protein and an Enzyme

1971 • 396 citations

KINETIC ANALYSIS OF ENZYME REACTIONS

1953 • 366 citations

Regulation in molluscan muscles

1970 • 351 citations

Isolation and Some Properties of Human Metallothionein^*

1966 • 326 citations

A New Protein Factor Promoting Aggregation of Tropomyosin

1965 • 281 citations

Kinetic and Magnetic Resonance Studies of the Pyruvate Kinase Reaction

1966 • 277 citations

Competition for zinc among serum albumin and amino acids

1972 • 235 citations

Metal-binding properties of human erythrocyte carbonic anhydrases

1964 • 226 citations

Metallocarboxypeptidases: Stability Constants and Enzymatic Characteristics

1961 • 222 citations

Kinetic and Magnetic Resonance Studies of the Pyruvate Kinase Reaction

1965 • 199 citations

Zinc and Metalloenzymes

1955 • 197 citations

Magnetic Resonance Studies of Manganese (II) Binding Sites of Pyruvate Kinase

1970 • 177 citations

Bicarbonate and the Binding of Iron to Transferrin

1967 • 177 citations

Structure of Thermolysin

1972 • 163 citations

The Mechanism of Activation of Trypsinogen. The Role of the Four N-Terminal Aspartyl Residues

1969 • 163 citations

Effects of specific divalent cations on some physical and chemical properties of glutamine synthetase from Escherichia coli. Taut and relaxed enzyme forms

1968 • 158 citations

Alpha-Amylases as Calcium-Metalloenzymes. II. Calcium and the Catalytic Activity^*

1964 • 153 citations

Role of calcium in thermolysin

1971 • 144 citations

δ-Aminolevulinic Acid Dehydratase of Rhodopseudomonas spheroides

1968 • 144 citations

Pyruvate Carboxylase

1966 • 138 citations

Regulation of glutamine synthetase. XI. The nature and implications of a lag phase in the Escherichia coli glutamine synthetase reaction

1968 • 133 citations

Nuclear magnetic resonance studies of the structure and binding sites of enzymes. I. Histidine residues.

1967 • 126 citations

Structure and arrangement of the regulatory subunits in aspartate transcarbamylase

1972 • 123 citations

Structural and functional zinc in horse liver alcohol dehydrogenase.

1967 • 120 citations

Nuclear magnetic resonance studies of the function of potassium in the mechanism of pyruvate kinase

1972 • 119 citations

Mechanism of Action of Guinea Pig Liver Transglutaminase

1970 • 119 citations

Metallocarboxypeptidases

1960 • 115 citations

Effects of metals on cells sub cellular elements and macro molecules

1970 • 108 citations

Evidence for Conformation Changes Induced by Substrates of Phosphoglucomutase

1965 • 103 citations

Escherichia coli citrate synthase. Purification and the effect of potassium on some properties

1969 • 103 citations

The binding of calcium to muscular parvalbumins

1972 • 102 citations

Effects of Temperature, Substrate, and Activating Cations on the Conformations of Pyruvate Kinase in Aqueous Solutions

1965 • 99 citations

Univalent Cations as Allosteric Activators of Muscle Adenosine 5'-Phosphate Deaminase

1967 • 99 citations

Protein difference spectra. Effect of solvent and charge on tryptophan

1972 • 92 citations

Regulatory Proteins of Muscle with Special Reference to Troponin

1973 • 89 citations

Specificity of metal ion interaction with concanavalin A

1973 • 87 citations

Hypothesis for a Neuronal Mechanism involved in Memory

1972 • 86 citations

Nuclear relaxation and kinetic studies of the role of Mn²⁺in the mechanism of enolase

1973 • 85 citations

Troponin Subunits and Their Interactions

1973 • 83 citations

The Effect of Magnesium on Some Physical Properties of Yeast Enolase

1966 • 82 citations

Rare earth metal ions as substitutes for the calcium ion in Bacillus subtilis .alpha.-amylase

1971 • 81 citations

The binding of Ca2 to trypsinogen and its relation to the mechanism of activation

1967 • 80 citations

Kinetic Study of the Activation Process of β‐Galactosidase from Escherichia coli by Mg²⁺

1972 • 78 citations

The Binding of Ions to the Muscle Proteins. Measurements on the Binding of Potassium and Sodium Ions to Myosin A, Myosin B and Actin^1,2

1957 • 78 citations

Effects of chemical modification on the activity of Crotalus adamanteus phospholipase A₂. Evidence for an essential amino group

1973 • 76 citations

Thallium-205 nuclear magnetic resonance as a probe for studying metal ion binding to biological macromolecules. Estimate of the distance between the monovalent and divalent activators of pyruvate kinase

1970 • 74 citations

Ca++ induced conformational changes in the Ca++ binding component of troponin

1972 • 73 citations

Crystal Structure of Human Erythrocyte Carbonic Anhydrase C. VI. The Three-dimensional Structure at High Resolution in Relation to Other Mammalian Carbonic Anhydrases

1972 • 70 citations

Allosteric Activation of Sheep Kidney Pyruvate Carboxylase by the Magnesium Ion (Mg2+) and the Magnesium Adenosine Triphosphate Ion (MgATP2-)

1967 • 70 citations

Functional anion binding sites in dogfish M4 lactate dehydrogenase

1973 • 70 citations

Alterations in the structure and function of Escherichia coli. Alkaline phosphatase due to zinc ion binding

1969 • 69 citations

δ-Aminolevulinic Acid Dehydratase of Rhodopseudomonas spheroides

1968 • 63 citations

Conformational Changes in Aspartate Transcarbamylase

1973 • 60 citations

Role of Bivalent Cations in the Phosphoglucomutase System

1969 • 59 citations

Localization of the Zinc Binding Site of Aspartate Transcarbamoylase in the Regulatory Subunit

1971 • 59 citations

Homoserine Dehydrogenase of Rhodospirillum rubrum

1965 • 56 citations

Effects of Silver and Mercurials on Yeast Alcohol Dehydrogenase

1960 • 55 citations

Equilibrium measurements of the interaction of yeast enolase with activating metal ions

1969 • 55 citations

Some Aspects of the Structure of Staphylococcal Nuclease: PART I. CRYSTALLOGRAPHIC STUDIES

1972 • 54 citations

Measurement of the Zinc Dissociation Constants of Alkaline Phosphatase from Escherichia coli by Equilibration with Zinc Ion Buffers^*

1966 • 53 citations

The Binding of Chloride and Sulfate Ions to Ribonuclease

1962 • 49 citations

Spectral perturbations of Crotalus adamanteus phospholipase A₂ induced by divalent cation binding

1973 • 48 citations

Structure and function of amylases

1971 • 47 citations

Exchangeability of bicarbonate specifically bound to transferrin

1973 • 46 citations

The Crystal Structure of Rhombohedral 2 Zinc Insulin

1972 • 45 citations

An X-ray crystallographic study of demetallized concanavalin A

1971 • 43 citations

Mechanism of Action of Guinea Pig Liver Transglutaminase

1967 • 43 citations

Binding of Ligands to the Inorganic Pyrophosphatase of Bakers' Yeast

1973 • 42 citations

The association-dissociation of formyltetrahydrofolate synthetase and its relation to monovalent cation activation of catalytic activity

1967 • 40 citations

The Enzymically Active Unit of Lactic Dehydrogenase

1971 • 39 citations

Use of Protein Difference Spectrophotometry to Determine Enzyme-Cofactor Dissociation Constants

1963 • 39 citations

Electron spin resonance study of the transition metal-binding site of concanavalin A

1969 • 39 citations

A Study of Troponin, a Myofibrillar Protein from Rabbit Skeletal Muscle

1968 • 39 citations

A crystallographic study of alkaline phosphatase at 7.7 Å resolution

1973 • 39 citations

Structure and function of amylases. II. Multiple forms of Bacillus subtilis α-amylase

1973 • 38 citations

Hydrogen-ion equilibria of conformational states of Escherichia colialkaline phosphatase

1968 • 38 citations

Mn++ BINDING BY PLASMA PROTEINS

1973 • 37 citations

The Effect of Univalent Cation Salts on the Stability and on Certain Physical Properties of Pyruvate Kinase

1967 • 35 citations

Abortive complexes of α-amylases with lanthanides

1973 • 35 citations

The Magnesium Ion (Mg2+) Activation of Sheep Kidney Pyruvate Carboxylase

1972 • 34 citations

Calorimetric determination of the enthalpies of binding of ions to deionized bovine serum albumin

1971 • 34 citations

Activation of spinach leaf ribulose-1,5-diphosphate carboxylase activities by magnesium ions

1968 • 33 citations

Energy Changes in Biochemical Reactions

1967 • 32 citations

Physical and biological properties of guinea pig insulin

1972 • 31 citations

Kinetic studies on the activation of yeast enolase by divalent cations

1969 • 27 citations

Suppression of hydrogen exchange in staphylococcal nuclease by ligands.

1968 • 26 citations

Co++ binding by plasma proteins

1973 • 25 citations

Homoserine Dehydrogenase of Rhodospirillum rubrum

1970 • 24 citations

Fructose 1, 6-Diphosphatase from Rabbit Liver

1971 • 24 citations

Circular dichroic and optical rotatory dispersion spectra of the threonine-inhibited aspartokinase-homoserine dehydrogenase of Escherichia coli K 12. Effects of ligand binding and protein denaturation

1970 • 23 citations

Formyltetrahydrofolate synthetase: Mechanism of cation activation

1965 • 23 citations

Energy Changes in Biochemical Reactions

1967 • 22 citations

Conformation changes of yeast phosphopyruvate hydratase (enolase) induced by activating and inhibiting metal ions

1965 • 22 citations

Necessity of Calcium for the Renaturation of Reduced Taka-amylase A

1965 • 21 citations

Role of Bivalent Cations in the Phosphoglucomutase System

1969 • 20 citations

Slow Conformational Changes of the Inorganic Pyrophosphatase from Bakers' Yeast Induced by Divalent Metal Ions

1973 • 16 citations

Effects of site symmetry and sequential metal binding upon protein titration (zinc insulin)

1967 • 16 citations

Metallocarboxypeptidases: A cadmium — Carboxypeptidase B with peptidase activity

1973 • 16 citations

Simultaneous binding of competitive ligands to horse liver alcohol dehydrogenase

1973 • 15 citations

Magnetic Resonance Studies of the Binding of Manganese to D-Fructose-1,6-diphosphate 1-Phosphohydrolase (Hexose-1,6-diphosphatase)

1973 • 12 citations

Ion binding by α-chymotrypsin

1969 • 12 citations

Interaction of chloride ion with horse liver alcohol dehydrogenase-reduced nicotinamide adenine dinucleotide complexes

1973 • 10 citations

Manganese substrate complexes of phosphofructokinase studied by pulsed magnetic resonance

1973 • 9 citations

Ion Binding by Adenosine Triphosphate-Creatine Phosphotransferase

1966 • 8 citations

Ion binding by metmyoglobin

1968 • 7 citations

Calorimetric investigation of the copper-bovine plasma albumin interaction

1973 • 7 citations