Intervening before the onset of Type 1 diabetes: baseline data from the European Nicotinamide Diabetes Intervention Trial (ENDIT)

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Diabetes Mellitus: Report of a WHO Study Group.

1986 • 869 citations

Effects of Insulin in Relatives of Patients with Type 1 Diabetes Mellitus

2002 • 803 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

Variation and trends in incidence of childhood diabetes in Europe

2000 • 748 citations

Enzyme immunoassay for intact human insulin in serum or plasma

1993 • 534 citations

CYCLOSPORIN INCREASES THE RATE AND LENGTH OF REMISSIONS IN INSULIN-DEPENDENT DIABETES OF RECENT ONSET

1986 • 443 citations

Prediction of IDDM in the General Population: Strategies Based on Combinations of Autoantibody Markers

1997 • 425 citations

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop.

1998 • 424 citations

Safety of high-dose nicotinamide: a review

2000 • 395 citations

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

1999 • 368 citations

Combined Analysis of Autoantibodies Improves Prediction of IDDM in Islet Cell Antibody-Positive Relatives

1994 • 360 citations

Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes

1990 • 356 citations

A Novel Micro-assay for Insulin Autoantibodies

1997 • 238 citations

The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes. DENIS Group.

1998 • 196 citations

Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide

1991 • 176 citations

Record-high incidence of Type I (insulin-dependent) diabetes mellitus in Finnish children

1999 • 173 citations

HLA-Encoded Genetic Predisposition in IDDM: DR4 Subtypes May Be Associated With Different Degrees of Protection

1997 • 150 citations

Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers

1997 • 149 citations

Variation and trends in incidence of childhood diabetes in Europe. EURODIAB ACE Study Group.

2000 • 137 citations

Standardization of IVGTT to Predict IDDM

1992 • 136 citations

Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-European Randomized Control Trial Group

1988 • 132 citations

Interactions of Age, Islet Cell Antibodies, Insulin Autoantibodies, and First-Phase Insulin Response in Predicting Risk of Progression to IDDM in ICA+ Relatives: The ICARUS Data Set

1996 • 122 citations

Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives

1994 • 114 citations

Optimized autoantibody-based risk assessment in family members. Implications for future intervention trials.

1999 • 92 citations

Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM?

1997 • 91 citations

Nicotinamide in type 1 diabetes. Mechanism of action revisited.

1999 • 89 citations

Islet autoantibodies, nationality and gender: a multinational screening study in first-degree relatives of patients with Type I diabetes

2002 • 79 citations

Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis

1999 • 75 citations

Nicotinamide — biological actions and therapeutic potential in diabetes prevention

1993 • 59 citations

Nicotinamide's Effects on Glucose Metabolism in Subjects at Risk For IDDM

1996 • 58 citations

Nicotinamide treatment in the prevention of insulin‐dependent diabetes mellitus

1993 • 46 citations

HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection

1997 • 41 citations

Comparison of Bolus and Infusion Protocols for Determining Acute Insulin Response to Intravenous Glucose in Normal Humans

1993 • 33 citations

Does partial preservation of residual beta-cell function justify immune intervention in recent onset Type I diabetes?

2001 • 30 citations

Nicotinamide and insulin secretion in normal subjects

1993 • 17 citations

Measurement of nicotinamide andN-methyl-2-pyridone-5-carboxamide in plasma by high performance liquid chromatography

1999 • 13 citations

Measurement ofN-methyl-2-pyridone-5-carboxamide in urine by high performance liquid chromatography

2000 • 11 citations