Down-regulation of β3 Adrenoreceptor Gene Expression in Brown Fat Cells Is Transient and Recovery Is Dependent upon a Short-lived Protein Factor

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

Molecular Characterization of the Human β ₃ -Adrenergic Receptor

1989 • 1,071 citations

Regulation of Adenylyl Cyclase-Coupled beta-Adrenergic Receptors

1988 • 389 citations

The role of mRNA and protein stability in gene expression

1989 • 370 citations

Effect of Diet and Cold Exposure on Norepinephrine Turnover in Brown Adipose Tissue of the Rat

1982 • 348 citations

An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity.

1991 • 291 citations

Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes.

1991 • 277 citations

Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels.

1988 • 268 citations

Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse

1978 • 257 citations

Alpha- and beta-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture.

1990 • 204 citations

cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.

1989 • 200 citations

Beta-adrenergic, cAMP-mediated stimulation of proliferation of brown fat cells in primary culture. Mediation via beta 1 but not via beta 3 adrenoceptors.

1992 • 189 citations

Regulation of Adrenergic Receptor Responsiveness Through Modulation of Receptor Gene Expression

1991 • 174 citations

Development of brown fat cells in monolayer culture

1983 • 154 citations

Agonist Regulation of Gene Expression of Adrenergic Receptors and G Proteins

1993 • 125 citations

Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements.

1992 • 120 citations

Coexisting beta-adrenoceptor subtypes: significance for thermogenic process in brown fat cells

1994 • 114 citations

The β-adrenergic radioligand [3H]CGP-12177, generally classified as an antagonist, is a thermogenic agonist in brown adipose tissue

1989 • 113 citations

Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool

1992 • 108 citations

Catecholamine sensitivity in brown fat cells from cold-acclimated hamsters and rats

1982 • 106 citations

Differential adrenergic regulation of beta 1- and beta 3-adrenoreceptor messenger ribonucleic acids in adipose tissues.

1992 • 98 citations

Regulation of the Uncoupling Protein Gene (Ucp) by β1, β2, and β3-Adrenergic Receptor Subtypes in Immortalized Brown Adipose Cell Lines

1995 • 91 citations

Synthesis of mitochondrial uncoupling protein in brown adipocytes differentiated in cell culture.

1990 • 73 citations

Noradrenergic stimulation of mitochondriogenesis in brown adipocytes differentiating in culture

1987 • 70 citations

Alpha 1-adrenergic receptor mRNA level is regulated by norepinephrine in rabbit aortic smooth muscle cells.

1990 • 70 citations

Transcriptional down-regulation by insulin of the beta 3-adrenergic receptor expression in 3T3-F442A adipocytes: a mechanism for repressing the cAMP signaling pathway.

1994 • 69 citations

Level of ETB receptor mRNA is down-regulated by endothelins through decreasing the intracellular stability of mRNA molecules

1992 • 59 citations

Norepinephrine utilizes alpha 1- and beta-adrenoreceptors synergistically to maximally induce c-fos expression in brown adipocytes

1994 • 57 citations

Cell-specific down-regulation of the beta 3-adrenergic receptor.

1994 • 56 citations

Expression of the β3-adrenergic receptor in human white adipose tissue

1993 • 55 citations

Analysis of human and rodent beta 3-adrenergic receptor messenger ribonucleic acids.

1994 • 53 citations

Desensitisation of β‐Adrenergic Responsiveness in vivo

1982 • 48 citations

Beta-1 receptor is the predominant beta-adrenoreceptor on rat brown adipose tissue.

1986 • 47 citations

Radioligand binding studies of the atypical β₃‐adrenergic receptor in rat brown adipose tissue using [³H]CGP 12177

1992 • 47 citations

Why do adipocytes make the β3 adrenergic receptor?

1995 • 45 citations

Modulation in vivo of β-adrenergic-receptor subtypes in rat brown adipose tissue by the thermogenic agonist Ro 16–8714

1992 • 45 citations

Differential down-regulation of β1- and β2-adrenergic receptor mRNA in C6 glioma cells

1990 • 42 citations

Stabilization of the mRNA for the uncoupling protein thermogenin by transcriptional/translational blockade and by noradrenaline in brown adipocytes differentiated in culture: a degradation factor induced by cessation of stimulation?

1994 • 42 citations

Physiological desensitization of beta 3-adrenergic responses in brown fat cells: involvement of a postreceptor process

1993 • 40 citations

Long Term Phorbol Ester Treatment Down-regulates the β3-Adrenergic Receptor in 3T3-F442A Adipocytes

1995 • 36 citations

Control of β3-adrenergic receptor gene expression in brown adipocytes in culture

1995 • 35 citations

Up-regulation of beta 1-adrenoceptor messenger ribonucleic acid in the rat pineal gland: nocturnally, through a beta-adrenoceptor-linked mechanism, and in vitro, through a novel posttranscriptional mechanism activated by specific protein synthesis inhibitors.

1993 • 29 citations

Attenuation of Gs α coupling efficiency in brown-adipose-tissue plasma membranes from cold-acclimated hamsters

1993 • 29 citations

Characterization of β₁‐ and β₃‐adrenoceptors in intact brown adipocytes of the rat

1995 • 27 citations

Thermal Balance in Health and Disease: Recent Basic Research and Clinical Progress

1994 • 26 citations

Regulation of mouse beta 3-adrenergic receptor gene expression and mRNA splice variants in adipocytes

1995 • 23 citations

Identification of a new cAMP response element-binding factor by southwestern blotting.

1993 • 20 citations

Characterization of a new, highly specific, beta 3-adrenergic receptor radioligand, [3H]SB 206606.

1994 • 19 citations

Parallel measurements of heat production and thermogenin content in brown fat cells during cold acclimation of rats

1986 • 19 citations

Cycloheximide induces the alpha 1B adrenergic receptor gene by activation of transcription in DDT1 MF-2 smooth muscle cells.

1993 • 18 citations

Cold acclimation induces desensitization to adenosine in brown fat cells without changing receptor binding

1990 • 17 citations

Protein kinase C and protein kinase A regulate the expression of angiotensin II receptor mRNA in smooth muscle cells

1994 • 11 citations

Molecular cloning of a novel putative G protein-coupled receptor from rat aortic smooth muscle. Downregulation of the mRNA level by the cyclic AMP messenger pathway

1994 • 11 citations

Variability in the regulation of β-adrenoceptor subtypes

1995 • 9 citations

Comparison of in vitro thermogenesis of brown adipose tissue in cold-acclimated rats and guinea pigs

1991 • 7 citations