Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

1997 • 657 citations

Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells

2002 • 655 citations

Clinical and biologic implications of recurrent genomic aberrations in myeloma

2003 • 648 citations

Advances in biology of multiple myeloma: clinical applications

2004 • 606 citations

The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid Transcripts

1998 • 555 citations

Molecular Pathogenesis and a Consequent Classification of Multiple Myeloma

2005 • 554 citations

The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis

1985 • 419 citations

Hypodiploidy is a major prognostic factor in multiple myeloma

2001 • 394 citations

Frequent Dysregulation of the c-maf Proto-Oncogene at 16q23 by Translocation to an Ig Locus in Multiple Myeloma

1998 • 388 citations

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression

2003 • 388 citations

Cytogenetic findings in 200 patients with multiple myeloma

1995 • 378 citations

Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma

2006 • 374 citations

Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma

2004 • 365 citations

Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation

2002 • 353 citations

Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients

2002 • 331 citations

Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization

2000 • 328 citations

Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy

2002 • 324 citations

Chromosome 13 abnormalities identified by FISH analysis and serum β2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy

2001 • 314 citations

Presence of a p53 Gene Deletion in Patients With Multiple Myeloma Predicts for Short Survival After Conventional-Dose Chemotherapy

1998 • 311 citations

The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma

2003 • 290 citations

Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors

2001 • 272 citations

Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma

2003 • 229 citations

Multiple myeloma: high incidence of chromosomal aneuploidy as detected by interphase fluorescence in situ hybridization.

1995 • 206 citations

p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation

2004 • 205 citations

The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant

2004 • 200 citations

A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains anIGH/MMSET fusion transcript

2003 • 194 citations

Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (delta13) in multiple myeloma: an eastern cooperative oncology group study.

2002 • 185 citations

Frequent Dysregulation of the c-maf Proto-Oncogene at 16q23 by Translocation to an Ig Locus in Multiple Myeloma

1998 • 179 citations

Focus on multiple myeloma

2004 • 169 citations

Both hypodiploidy and deletion of chromosome 13 independently confer poor prognosis in multiple myeloma

2002 • 163 citations

Prognostic and Therapeutic Significance of Myeloma Genetics and Gene Expression Profiling

2005 • 131 citations

Ploidy, as detected by fluorescence in situ hybridization, defines different subgroups in multiple myeloma

2004 • 114 citations

Prognostic implications of tumor cell DNA and RNA content in multiple myeloma

1985 • 113 citations

Clinical Outcomes in t(4;14) Multiple Myeloma: A Chemotherapy-Sensitive Disease Characterized by Rapid Relapse and Alkylating Agent Resistance

2005 • 98 citations

Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol

2005 • 96 citations

Maintenance Treatment with Thalidomide after Autologous Transplantation for Myeloma: Final Analysis of a Prospective Randomized Study of the “Intergroupe Francophone du Myelome”.

2005 • 46 citations

Presence of a p53 Gene Deletion in Patients With Multiple Myeloma Predicts for Short Survival After Conventional-Dose Chemotherapy

1998 • 25 citations

Prognostic implications of tumor cell DNA and RNA content in multiple myeloma

1985 • 5 citations

Cited By (0)

Loading...