Epigenetic Inactivation of the HOXA Gene Cluster in Breast Cancer

Bioconductor: open software development for computational biology and bioinformatics.

2004 • 11,755 citations

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

2005 • 1,704 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins

2004 • 1,049 citations

Compromised HOXA5 function can limit p53 expression in human breast tumours

2000 • 466 citations

Purification of CpG islands using a methylated DNA binding column

1994 • 449 citations

Methylation profiling of CpG islands in human breast cancer cells

1999 • 434 citations

Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band

2006 • 398 citations

Hypomethylation of pericentromeric DNA in breast adenocarcinomas

1998 • 263 citations

Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors

2002 • 197 citations

Sequence and detailed organization of the human caveolin‐1 and ‐2 genes located near the D7S522 locus (7q31.1)

1999 • 151 citations

Tumor Suppressor p16INK4A Regulates Polycomb-mediated DNA Hypermethylation in Human Mammary Epithelial Cells

2006 • 144 citations

Epigenetic silencing of DSC3 is a common event in human breast cancer

2005 • 113 citations

Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression

2003 • 99 citations

Epigenomic Changes during Leukemia Cell Differentiation: Analysis of Histone Acetylation and Cytosine Methylation Using CpG Island Microarrays

2004 • 83 citations