Inhibition of the in vivo biosynthesis and changes of catecholamine levels in rat brain after ?-methyl-p-tyrosine; time- and dose-response relationships

Introduction to Statistical Analysis.

1957 • 5,236 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Tyrosine Hydroxylase

1964 • 2,038 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

A fluorometric method for the estimation of tyrosine in plasma and tissues.

1957 • 973 citations

An Introduction to Statistical Analysis.

1957 • 916 citations

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.

1965 • 813 citations

Application of steady state kinetics to the estimation of synthesis rate and turnover time of tissue catecholamines.

1966 • 709 citations

Self-inhibition by Dopaminergic Neurons

1975 • 645 citations

A sensitive method for spectrophotofluorometric assay of catecholamines

1964 • 557 citations

Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones

1973 • 436 citations

Neuropsychopharmacology of monoamines and their regulatory enzymes.

1974 • 416 citations

Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain

1971 • 405 citations

Grundlagen der Pharmakokinetik

1968 • 377 citations

Brain Catechol Synthesis: Control by Brain Tyrosine Concentration

1974 • 367 citations

Advances in Neurology. Vol. 2

1974 • 364 citations

Inhibitors of purified beef adrenal tyrosine hydroxylase

1965 • 327 citations

Biochemistry and pharmacology of the basal ganglia

1965 • 293 citations

Control of brain neurotransmitter synthesis by precursor availability and nutritional state

1976 • 271 citations

The determination of dopamine by a modification of the dihydroxyindole fluorimetric assay

1973 • 252 citations

Regulation of monoamine metabolism in the central nervous system.

1972 • 241 citations

Central effects of an inhibitor of tyrosine hydroxylation

1966 • 222 citations

Advances in biochemical psychopharmacology

1971 • 214 citations

Alterations in behavior and brain catecholamine levels in rats treated with alpha-methyltyrosine.

1966 • 203 citations

Effect of chlorpromazine on accumulation and disappearance of catecholamines formed from tyrosine-C14 in brain.

1968 • 171 citations

DYNAMIC CHARACTERISTICS OF THE 'FUNCTIONAL COMPARTMENT' OF DOPAMINE IN DOPAMINERGIC TERMINALS OF THE RAT STRIATUM

1971 • 164 citations

Blockade of intravenous amphetamine euphoria in man

1971 • 140 citations

Behavioral effects of -α-methyltyrosine, an inhibitor of tyrosine hydroxylase

1965 • 133 citations

A new class of tyrosine hydroxylase inhibitors and a simple assay of inhibition in vivo

1967 • 122 citations

Catecholamines and mania: The effect of alpha‐methyl‐para‐tyrosine on manic behavior and catecholamine metabolism

1971 • 99 citations

The disruption of conditioned avoidance response following selective depletion of brain catechol amines

1965 • 94 citations

Effects of some psychotropic drugs on dopamine synthesis in the rat striatum.

1971 • 92 citations

Potentiation of phenothiazines by?-methyltyrosine in treatment of chronic schizophrenia

1972 • 86 citations

The relative role of storage and synthesis of brain norepinephrine in the psychomotor stimulation evoked by amphetamine or by desipramine and tetrabenazine

1968 • 80 citations

Tyrosine hydroxylase inhibitors.

1971 • 77 citations

Effects of α-methyltyrosine on brain catecholamines and conditioned behavior in guinea pigs

1966 • 76 citations

On the role of brain catecholamines in motor activity: Experiments with inhibitors of synthesis and of monoamine oxidase

1970 • 74 citations

Metabolism of α-methyltyrosine in man: relationship to its potency as an inhibitor of catecholamine biosynthesis

1968 • 72 citations

Effect of neuroleptic drugs on central catecholamine turnover assessed using tyrosineand dopamine-β-hydroxylase inhibitors

1972 • 70 citations

Antagonism of d-amphetamine by alpha-methyl-l-tyrosine: Behavioral evidence for the participation of catecholamine stores and synthesis in the amphetamine stimulant response

1970 • 69 citations

Effect of alpha-methyltyrosine on operant behavior and brain catecholamine levels.

1969 • 69 citations

Inhibitors of endogenous catecholamine biosynthesis.

1966 • 65 citations

Potentiation by Metyrosine of Thioridazine Effects in Chronic Schizophrenics

1976 • 64 citations

Compartmentation of dopamine in rat striatum.

1974 • 63 citations

Acute effects of alpha-methyltyrosine on brain catecholamine levels and on spontaneous and amphetamine-stimulated motor activity in mice.

1969 • 58 citations

A critical assessment of methods for the determination of monoamine synthesis turnover rates in vivo.

1974 • 55 citations

Subcellular localization of tyrosine hydroxylase in beef caudate nucleus

1965 • 54 citations

Effects of Reserpine and α-Methyltyrosine on Brain Catecholamines and the Pituitary-Adrenal Response to Stress

1968 • 54 citations

Effects ofα-methyl-p-tyrosine upon cerebral amine metabolism and sleep states in the cat

1974 • 53 citations

Self-inhibition by dopaminergic neurones: Disruption by (±)-α-methyl-p-tyrosine pretreatment or anterior diencephalic lesions

1976 • 50 citations

The effect of nutritional factors on brain amino acid levels and monoamine synthesis.

1976 • 47 citations

Simple neuronal models to estimate turnover rate of noradrenergic transmitters in vivo.

1970 • 44 citations

Regional Disappearance of Catecholamines Formed from ¹⁴C‐Tyrosine in Rat Brain: Effect of Synthesis Inhibitors and of Chlorpromazine

1972 • 41 citations

Biochemical and behavioural effects of tyrosine hydroxylase inhibition

1967 • 40 citations

Catalepsy, Sedation and Hypothermia Induced by Alpha-Methyl-p-Tyrosine in the Rat. An Ideal Tool for Screening of Drugs Active on Central Catecholaminergic Receptors**)

1973 • 38 citations

ELECTROPHYSIOLOGICAL EFFECTS OF AMPHETAMINE ON DOPAMINERGIC NEURONS

1973 • 30 citations

Some problems encountered in attempting to estimate catecholamine turnover using labelled tyrosine

1970 • 29 citations

Effects of alpha-methyltyrosine on REM sleep and brain amine levels in the cat.

1973 • 28 citations

Enhanced sensitivity to noradrenergic agonists and tolerance development to -methyltyrosine in the rat.

1972 • 27 citations

Isolation and determination of free endogenous and radioactive tyrosine in studies on catecholamine synthesis in the rat brain

1968 • 25 citations

On the Relation between Motor Activity and the Degree of Enzyme Inhibition Following Inhibition of Tyrosine Hydroxylase

1971 • 22 citations

A fluorometric method combined with thin layer chromatography for the determination of norepinephrine, epinephrine and dopamine in human urine

1972 • 18 citations

The relationship between amphetamine antagonism and depletion of brain catecholamines by alpha-methyl-p-tyrosine in rats

1978 • 13 citations

The effects of dl-p-chlorophenylalanine and dl-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat

1975 • 12 citations

Electrophysiological effects of amphetamine on dopaminergic neurons

1974 • 7 citations