Adjuvant Activity of Monophosphoryl Lipid A for Nasal and Oral Immunization with Soluble or Liposome-Associated Antigen

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Van Damme A.

1986 • 3,477 citations

Growth characteristics of group A streptococci in a new chemically defined medium

1980 • 472 citations

Vaccine design : the subunit and adjuvant approach

1995 • 449 citations

Monophosphoryl lipid A as an adjuvant. Past experiences and new directions.

1995 • 283 citations

Induction of mucosal immunity by intranasal application of a streptococcal surface protein antigen with the cholera toxin B subunit

1993 • 241 citations

Liposomal malaria vaccine in humans: a safe and potent adjuvant strategy.

1992 • 231 citations

Monophosphoryl Lipid A as an Adjuvant

1995 • 214 citations

Nasal lymphoid tissue, intranasal immunization, and compartmentalization of the common mucosal immune system

1997 • 182 citations

Nasal Lymphoid Tissue (NALT) as a Mucosal Immune Inductive Site

1997 • 170 citations

Systemic immunization with pneumococcal polysaccharide vaccine induces a predominant IgA2 response of peripheral blood lymphocytes and increases of both serum and secretory anti-pneumococcal antibodies.

1988 • 160 citations

Nasal Immunization of Mice with Human Papillomavirus Type 16 Virus-Like Particles Elicits Neutralizing Antibodies in Mucosal Secretions

1998 • 159 citations

Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system

1998 • 158 citations

Novel Delivery Systems for Oral Vaccines

1994 • 155 citations

Antibodies and Antibody-Secreting Cells in the Female Genital Tract after Vaginal or Intranasal Immunization with Cholera Toxin B Subunit or Conjugates

1998 • 154 citations

Specific secretory immune responses in the female genital tract following intranasal immunization with a recombinant adenovirus expressing glycoprotein B of herpes simplex virus

1995 • 153 citations

Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A).

1996 • 142 citations

Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages

1997 • 132 citations

Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration

2000 • 130 citations

Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination

1990 • 124 citations

Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against human immunodeficiency virus type 1

1997 • 96 citations

Intranasal immunization with proteoliposomes protects against influenza

1989 • 93 citations

Mucosal immunoadjuvant activity of liposomes: induction of systemic IgG and secretory IgA responses in mice by intranasal immunization with an influenza subunit vaccine and coadministered liposomes

1995 • 91 citations

Liposomes Containing Lipid A Serve as an Adjuvant for Induction of Antibody and Cytotoxic T-Cell Responses against RTS,S Malaria Antigen

1998 • 87 citations

Musosal immunoadjuvant activity of recombinant Escherichia coli heatlabile enterotoxin and its B subunit: Induction of systemic IgG and secretory IgA responses in mice by intranasal immunization with influenza virus surface antigen

1998 • 86 citations

Intranasal immunization with bacterial polysaccharide containing liposomes enhances antigen-specific pulmonary secretory antibody response

1992 • 83 citations

Comparison of Intranasal and Intramuscular Immunization against Human Immunodeficiency Virus Type 1 with a DNA-Monophosphoryl Lipid A Adjuvant Vaccine

1998 • 80 citations

Mucosal but Not Parenteral Immunization with Purified Human Papillomavirus Type 16 Virus-Like Particles Induces Neutralizing Titers of Antibodies throughout the Estrous Cycle of Mice

1999 • 76 citations

Adjuvant effects of liposomes containing lipid A: enhancement of liposomal antigen presentation and recruitment of macrophages

1992 • 74 citations

Safety, Immunogenicity, and Efficacy of a Malaria Sporozoite Vaccine Administered with Monophosphoryl Lipid A, Cell Wall Skeleton of Mycobacteria, and Squalane as Adjuvant

1994 • 71 citations

Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: the effect of adjuvants on mucosal and serum antibody responses

1998 • 70 citations

Liposomes

1987 • 69 citations

Intranasal immunization with liposomes containing IL-2 enhances bacterial polysaccharide antigen-specific pulmonary secretory antibody response.

1992 • 63 citations

Ballistic Electrons in Semiconductors

1987 • 60 citations

Intranasal and intramuscular proteosome-staphylococcal enterotoxin B (SEB) toxoid vaccines: immunogenicity and efficacy against lethal SEB intoxication in mice

1996 • 58 citations

Liposomes as an immunoadjuvant system for stimulation of mucosal and systemic antibody responses against inactivated measles virus administered intranasally to mice

1995 • 55 citations

[6] Use of liposomes as biodegradable and harmless adjuvants

1983 • 54 citations

Induction of immune response against a short synthetic peptide antigen coupled to small neutral liposomes containing monophosphoryl lipid a

1993 • 54 citations

Systemic and mucosal immune responses of mice to aluminium-adsorbed or aluminium-non-adsorbed tetanus toxoid administered intranasally with recombinant cholera toxin B subunit

1998 • 52 citations

Liposomes containing lipid A: A potent nontoxic adjuvant for a human malaria sporozoite vaccine

1990 • 52 citations

Immunogenicity of liposomal malaria sporozoite antigen in monkeys: adjuvant effects of aluminium hydroxide and non-pyrogenic liposomal lipid A

1989 • 52 citations

The B-cell development in tonsillar lymphoid follicles.

1996 • 50 citations

Induction of a secretory IgA response in the murine female urogenital tract by immunization of the lungs with liposome-supplemented viral subunit antigen

1995 • 48 citations

Cytotoxic T lymphocytes to Ebola Zaire virus are induced in mice by immunization with liposomes containing lipid A

1999 • 47 citations

Specific mucosal immunity and enhanced nasopharyngeal clearance of nontypeable Haemophilus influenzae after intranasal immunization with outer membrane protein P6 and cholera toxin

1998 • 45 citations

Nasal immunization with group B streptococci can induce high levels of specific IgA antibodies in cervicovaginal secretions of mice

1997 • 44 citations

Enhanced mucosal priming by cholera toxin and procholeragenoid with a lipoidal amine adjuvant (avridine) delivered in liposomes

1984 • 43 citations

Reversal of Age-Related Deficient Influenza Virus-Specific CTL Responses and IFN-γ Production by Monophosphoryl Lipid A

1996 • 42 citations

Oral immunization of humans with dehydrated liposomes containing Streptococcus mutans glucosyltransferase induces salivary immunoglobulin A₂ antibody responses

1994 • 41 citations

Induction of cytolytic and antibody responses using Plasmodium falciparum repeatless circumsporozoite protein encapsulated in liposomes

1993 • 40 citations

Functional and Immunogenic Characterization of Two Cloned Regions of Streptococcus mutans Glucosyltransferase I

1999 • 40 citations

Enhanced immunogenicity of a recombinant genital warts vaccine adjuvanted with monophosphoryl lipid A

1998 • 36 citations

Characterization of liposome suspensions by flow cytometry

1989 • 36 citations

Isolation and characterization of an extracellular glucosyltransferase synthesizing insoluble glucan from Streptococcus mutans serotype c

1985 • 36 citations

Activation of systemic and mucosal immune response following nasal administration of liposomes

1994 • 34 citations

Analysis of a monophosphoryl lipid A immunostimulant preparation from Salmonella minnesota R595 by high-performance liquid chromatography

1997 • 34 citations

Enhancement by Lipid A of Mucosal Immunogenicity of Liposome-Associated Cholera Toxin

1984 • 33 citations

Intranasal immunization of mice with recombinant protein antigen of serotype cStreptococcus mutans and cholera toxin B subunit

1990 • 26 citations

Monophosphoryl lipid A behaves as a T-cell-independent type 1 carrier for hapten-specific antibody responses in mice

1995 • 25 citations

Oral immunization with recombinant Salmonella typhimurium expressing a cloned Porphyromonas gingivalis hemagglutinin: effect of boosting on mucosal, systemic and immunoglobulin G subclass response

1998 • 25 citations

Efficacy of tumor cell vaccine after incorporating monophosphoryl lipid A (MPL) in tumor cell membranes containing tumor-associated ganglioside

1994 • 19 citations

Properties of practical oral liposome‐Streptococcus mutans glucosyltransferase vaccines for effective induction of caries protection

1996 • 17 citations

Stimulation of secretory antibodies against Bordetella pertussis antigens in the lungs of mice after oral or intranasal administration of liposome-incorporated cell-surface antigens

1993 • 16 citations

Attachment of Monophosphoryl Lipid A (MPL) to Cells and Liposomes Augments Antibody Response to Membrane-bound Gangliosides

1994 • 12 citations

Intranasal antigen targeting to MHC class II molecules primes local IgA and serum IgG antibody responses in mice

1997 • 12 citations