Viability measurements in mammalian cell systems

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

Defense Strategies Against Hypoxia and Hypothermia

1986 • 1,098 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity.

1987 • 705 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Comparison of in vitro methods to determine drug-induced cell lethality.

1976 • 278 citations

Early Repair Processes in Marrow Cells Irradiated and Proliferating in Vivo

1963 • 255 citations

A novel dye exclusion method for testing in vitro chemosensitivity of human tumors.

1983 • 241 citations

A Multicomponent X-ray Survival Curve for Mouse Lymphosarcoma Cells irradiated in vivo

1963 • 224 citations

EXPERIMENTAL STUDIES UPON LYMPHOCYTES

1917 • 221 citations

Electrical Counting and Sizing of Mammalian Cells in Suspension

1965 • 201 citations

Potential Pitfalls of [³H]Thymidine Techniques to Measure Cell Proliferation

1981 • 193 citations

The Action of Vital Stains Belonging to the Benzidine Group

1914 • 157 citations

Comparison of dye exclusion assays with a clonogenic assay in the determination of drug-induced cytotoxicity.

1983 • 151 citations

Calcium-dependent and calcium-independent mechanisms of irreversible cell injury in cultured hepatocytes.

1986 • 149 citations

The ATP assay is more sensitive than the succinate dehydrogenase inhibition test for predicting cell viability

1987 • 139 citations

Comparison of different methods of determining cell viability after exposure to cytotoxic compounds

1976 • 137 citations

Effects of hyperthermia on dividing Chinese hamster ovary cells and on microtubules in vitro.

1982 • 118 citations

APPLICATIONS OF NMR TO STUDIES OF TISSUE METABOLISM

1986 • 108 citations

Rapid loss of stress fibers in Chinese hamster ovary cells after hyperthermia.

1985 • 92 citations

Na⁺+ K⁺+ 2 Cl⁻ Cotransport in Animal Cells—Its Role in Volume Regulation^a

1985 • 92 citations

A direct correlation between hyperthermia‐induced membrane blebbing and survival in synchronous G₁ CHO cells

1986 • 82 citations

Observations on cell volume, ultrastructure, mitochondrial conformation and vital-dye uptake in Ehrlich ascites tumor cells. Effects of inhibiting energy production and function of the plasma membrane.

1971 • 77 citations

Investigation of adenylate energy charge, phosphorylation potential, and ATP concentration in cells stressed with starvation and heat

1985 • 69 citations

Relationship between intracellular pH and energy metabolism in dog brain as measured by 31P-NMR

1987 • 66 citations

A General Method for the Quantitation of Immune Cytolysis

1961 • 66 citations

Direct membrane-damaging effect of ketoconazole and tioconazole on Candida albicans demonstrated by bioluminescent assay of ATP

1984 • 63 citations

A Survival Curve for Mammalian Cells irradiated in vivo

1959 • 61 citations

Neuraminidase and Cell Viability: Failure to Detect Cytotoxic Effects With Dye-Exclusion Techniques 2

1974 • 48 citations

Effects of clumps and clusters on survival measurements with clonogenic assays.

1985 • 44 citations

Surface and shape changes during cell division

1980 • 42 citations

The relationship between cell viability and changes in mitochondrial ultrastructure, cellular ATP, ion and water content following injury of Ehrlich ascites tumor cells

1974 • 39 citations

Substrate analyses in single cells

1975 • 37 citations

The Lung-colony Assay: Extension to the Lewis Lung Tumour and the B16 Melanoma–Radiosensitivity of B16 Melanoma Cells

1975 • 31 citations

The uptake of non-metabolizable amino acids as an index of cell viability in vitro

1970 • 30 citations

Esterase Activity, Exclusion of Propidium Iodide, and Proliferation in Tumor Cells Exposed to Anticancer Agents: Phenomena Relevant to Chemosensitivity Determinations

1985 • 25 citations

51Cr-uptake assay a sensitive and reliable method to quantitate cell viability and cell death

1987 • 25 citations

Assessment of the sensitivity of leukaemic cells to cytotoxic drugs by bioluminescence measurement of ATP in cultured cells

1986 • 22 citations

High resolution autoradiography with 51Cr

1969 • 21 citations

Cell‐Mediated Cytotoxicity for Melanoma Tumor Cells: Detection by a (³H) Proline Release Assay

1976 • 20 citations

A re-examination of succinic dehydrogenase activity and its association with cell death in the interdigit of the chick foot

1974 • 16 citations

Labelling of lymphocytes with various radioisotopes for in vivo tracer studies; A review

1977 • 15 citations

67 Ga-Citrate and 125 I-Iododeoxyuridine as Markers for In Vivo Evaluation of Tumor Cell Metastasis and Death 2

1973 • 9 citations

EFFECT OF TRITIATED THYMIDINE ON THE KINETICS AND VIABILITY OF 9L CELLS IN VITRO

1981 • 6 citations

A rapid alternative to the clonogenic assay for measuring antibody and complement-mediated killing of tumor cells

1985 • 5 citations

Rapid assay system for cytotoxicity tests using 14C-leucine incorporation into tumor cells.

1980 • 4 citations

A comparison of clonogenic and radionuclide uptake assays for determining the radiation response of human small-cell lung cancer xenografts and cell lines

1987 • 4 citations