Mechanism for the paradoxical inhibition and stimulation of calcineurin by the immunosuppresive drug tacrolimus (FK506)

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Calcineurin: Form and Function

2000 • 1,336 citations

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin

1998 • 892 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

A continuous spectrophotometric assay for inorganic phosphate and for measuring phosphate release kinetics in biological systems.

1992 • 527 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Identification of an autoinhibitory domain in calcineurin.

1990 • 268 citations

FK506, An Immunosuppressant Targeting Calcineurin Function

2000 • 242 citations

Calcineurin and Beyond

2000 • 227 citations

Calmodulin-stimulated dephosphorylation of p-nitrophenyl phosphate and free phosphotyrosine by calcineurin.

1983 • 198 citations

Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity.

1986 • 187 citations

Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B.

1992 • 168 citations

Use of fluorinated tyrosine phosphates to probe the substrate specificity of the low molecular weight phosphatase activity of calcineurin.

1985 • 122 citations

Calcineurin and hypertrophic heart disease: novel insights and remaining questions

2002 • 107 citations

Activation of brain calcineurin phosphatase towards nonprotein phosphoesters by Ca2+, calmodulin, and Mg2+.

1984 • 83 citations

Cyclophilin Residues That Affect Noncompetitive Inhibition of the Protein Serine Phosphatase Activity of Calcineurin by the Cyclophilin.cntdot.Cyclosporin A Complex

1994 • 74 citations

Calcium- and calmodulin-sensitive interactions of calcineurin with phospholipids.

1987 • 40 citations

Regulation of Calcineurin Phosphatase Activity by Its Autoinhibitory Domain

1999 • 39 citations

Anti-T cell strategies in asthma

1999 • 35 citations

Synergism between the Calmodulin-binding and Autoinhibitory Domains on Calcineurin Is Essential for the Induction of Their Phosphatase Activity

2000 • 34 citations

Understanding Enzyme Inhibition

2000 • 31 citations

Glutamine and regulation of gene expression in rat hepatocytes: The role of cell swelling

1998 • 21 citations

Inhibition of calcineurin by the tyrphostin class of tyrosine kinase inhibitors

1998 • 18 citations

Competitive and Slow-Binding Inhibition of Calcineurin by Drug · Immunophilin Complexes

1998 • 13 citations