The Role of Immune Complexes in the Pathogenesis of Disease

Biologic and clinical significance of cryoglobulins

1974 • 1,635 citations

The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells.

1972 • 1,102 citations

IMMUNOLOGICAL STUDIES CONCERNING THE NEPHRITIS OF SYSTEMIC LUPUS ERYTHEMATOSUS

1967 • 881 citations

EXPERIMENTAL GLOMERULONEPHRITIS

1961 • 730 citations

Abnormal histidine metabolism in thyrotoxicosis in man. A possible index of impaired folate function.

1965 • 611 citations

ANTIBODIES TO POLYNUCLEOTIDES IN HUMAN SERA: ANTIGENIC SPECIFICITY AND RELATION TO DISEASE

1971 • 511 citations

Circulating Immune Complexes in the Serum in Systemic Lupus Erythematosus and in Carriers of Hepatitis B Antigen QUANTITATION BY BINDING TO RADIOLABELED Clq

1974 • 436 citations

Detection of Antibodies and Soluble Antigen-Antibody Complexes by Precipitation with Polyethylene Glycol

1973 • 422 citations

AN UNUSUAL PROTEIN COMPONENT OF HIGH MOLECULAR WEIGHT IN THE SERUM OF CERTAIN PATIENTS WITH RHEUMATOID ARTHRITIS

1957 • 391 citations

CELL SURFACE IMMUNOGLOBULIN

1971 • 380 citations

IMMUNE COMPLEXES IN HEPATITIS

1969 • 357 citations

Chemotaxis and Inflammation

1974 • 353 citations

A COMPARATIVE HISTOLOGIC AND IMMUNOLOGIC STUDY IN RABBITS OF INDUCED HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE

1953 • 321 citations

SYSTEMIC LUPUS ERYTHEMATOSUS: PROTOTYPE OF IMMUNE COMPLEX NEPHRITIS IN MAN

1971 • 320 citations

ERYTHEMA NODOSUM LEPROSUM: A CLINICAL MANIFESTATION OF THE ARTHUS PHENOMENON

1969 • 309 citations

GAMMA GLOBULIN COMPLEXES IN RHEUMATOID ARTHRITIS AND CERTAIN OTHER CONDITIONS

1961 • 307 citations

C1q PRECIPITINS IN THE SERA OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND OTHER HYPOCOMPLEMENTEMIC STATES: CHARACTERIZATION OF HIGH AND LOW MOLECULAR WEIGHT TYPES

1971 • 300 citations

Causes of death in the aged.

1950 • 296 citations

INTERACTION OF CELLS WITH IMMUNE COMPLEXES: ADHERENCE, RELEASE OF CONSTITUENTS, AND TISSUE INJURY

1971 • 255 citations

[Pathogenesis of serum sickness].

1959 • 252 citations

The Occurrence of Single-Stranded DNA in the Serum of Patients with Systemic Lupus Erythematosus and Other Diseases

1973 • 244 citations

EFFECT OF DIPYRIDAMOLE ON HUMAN PLATELET BEHAVIOUR

1965 • 244 citations

Demonstration of Immune Complexes in Spontaneous and Histamine-Induced Lesions and in Normal Skin of Patients with Leukocytoclastic Angiitis

1975 • 240 citations

Phagocytosis: recognition and ingestion.

1975 • 229 citations

The Choroid Plexus in Systemic Lupus Erythematosus

1972 • 221 citations

MECHANISMS INVOLVED IN THE DEPOSITION OF IMMUNE COMPLEXES IN TISSUES

1971 • 220 citations

Drug-induced immune hemolytic anemia

1975 • 217 citations

THE FIRST COMPONENT OF THE KININ-FORMING SYSTEM IN HUMAN AND RABBIT PLASMA

1971 • 216 citations

Analyses of Lymphocytes from Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus OCCURRENCE OF INTERFERING COLD-REACTIVE ANTILYMPHOCYTE ANTIBODIES

1974 • 194 citations

DNA:Anti-DNA Complexes: Their Detection in Systemic Lupus Erythematosus Sera

1973 • 194 citations

Pathoanatomic, Pathophysiologic and Clinical Correlations in Endocarditis

1974 • 193 citations

The pathogenesis of arthritis associated with acute hepatitis-B surface antigen-positive hepatitis. Complement activation and characterization of circulating immune complexes.

1975 • 193 citations

NECROBACILLOSIS

1948 • 192 citations

STUDIES ON CIRCULATING IMMUNE COMPLEXES

1968 • 192 citations

ACUTE IMMUNE COMPLEX DISEASE IN RABBITS

1971 • 188 citations

THE INDUCTION OF A RHEUMATOID FACTOR-LIKE SUBSTANCE IN RABBITS

1961 • 184 citations

Complement-derived leukotactic factors in inflammatory synovial fluids of humans

1971 • 183 citations

Circulating immune complexes in inflammatory bowel disease.

1973 • 179 citations

CUTANEOUS AND VISCERAL SYNDROMES OF NECROTIZING OR “ALLERGIC” ANGIITIS

1964 • 178 citations

Structural components of epithelial and endothelial basement membranes

1969 • 174 citations

PATHOGENIC FACTORS IN VASCULAR LESIONS OF EXPERIMENTAL SERUM SICKNESS

1965 • 172 citations

EVIDENCE FOR COMPLEMENT-BINDING IMMUNE COMPLEXES IN ADULT CŒLIAC DISEASE, CROHN'S DISEASE, AND ULCERATIVE COLITIS

1973 • 166 citations

Occurrence of -globulin complexes in serum and joint fluid of rheumatoid arthritis patients: use of monoclonal rheumatoid factors as reagents for their demonstration.

1971 • 163 citations

BINDING OF SOLUBLE IMMUNE COMPLEXES TO HUMAN LYMPHOBLASTOID CELLS

1974 • 162 citations

VASCULITIS IN ASSOCIATION WITH AUSTRALIA ANTIGEN

1971 • 161 citations

Diagnosis of immunopathologic renal disease

1974 • 160 citations

CIRCULATING IMMUNE COMPLEXES IN DERMATITIS HERPETIFORMIS

1973 • 156 citations

The immunopathological significance of the heterogeneity of antibody affinity.

1971 • 156 citations

Localization of fluorescein-labeled antinucleoside antibodies in glomeruli of patients with active systemic lupus erythematosus nephritis

1970 • 152 citations

QUANTITATION OF ACUTE AND CHRONIC SERUM SICKNESS IN THE RABBIT

1971 • 146 citations

THE REACTION OF THE LUPUS ERYTHEMATOSUS (L.E.) CELL FACTOR WITH DEOXYRIBONUCLEOPROTEIN OF THE CELL NUCLEUS

1959 • 145 citations

Antiglobulin factors in sera from patients with rheumatoid arthritis and normal subjects. Quantitative estimation in different immunoglobulin classes.

1967 • 143 citations

Lymphokines in the rheumatoid joint

1975 • 140 citations

IMMUNE COMPLEX DISEASE IN CHRONIC VIRAL INFECTIONS

1971 • 135 citations

Recent observations and concepts in immunological unresponsiveness and autoimmunity.

1971 • 133 citations

OCCURRENCE OF γ-GLOBULIN COMPLEXES IN SERUM AND JOINT FLUID OF RHEUMATOID ARTHRITIS PATIENTS: USE OF MONOCLONAL RHEUMATOID FACTORS AS REAGENTS FOR THEIR DEMONSTRATION

1971 • 133 citations

Immune complex systems in the nephritis of systemic lupus erythematosus

1973 • 131 citations

Immunoglobulin synthesis by peripheral blood cells in systemic lupus erythematosus

1975 • 131 citations

Immunofluorescence of Cutaneous Vasculitis Associated With Systemic Disease

1971 • 130 citations

Immunopathologic Study of Sural Nerves in Rheumatoid Arthritis

1972 • 130 citations

IgM rheumatoid factor and low molecular weight IgM. An association with vasculitis

1974 • 129 citations

ANTIGEN-ANTIBODY REACTIONS IN JEJUNAL MUCOSA IN CHILDHOOD CŒLIAC DISEASE AFTER GLUTEN CHALLENGE

1972 • 129 citations

Immunopathogenesis of Syphilitic Glomerulonephritis

1975 • 127 citations

QUANTITATIVE STUDIES ON THE MIXED LYMPHOCYTE INTERACTION IN RATS

1971 • 127 citations

Studies of Cryoproteins in Systemic Lupus Erythematosus*

1967 • 122 citations

FATE OF PREFORMED IMMUNE COMPLEXES IN RABBITS AND RHESUS MONKEYS

1971 • 119 citations

Human Necrotizing Vasculitis: Immunoglobulins and Complement in Vessel Walls of Cutaneous Lesions and Normal Skin

1975 • 118 citations

Pigeon-Breeder’s Disease

1974 • 117 citations

Complement fixation by rheumatoid factor.

1975 • 116 citations

LAXAN NEPHROPATHY

1975 • 115 citations

Chemical studies on Clq; A modulator of immunoglobulin biology

1971 • 115 citations

Chronic Membranous Glomerulonephritis Caused by Hepatitis B Antigen-Antibody Immune Complexes

1974 • 113 citations

Immunopathogenesis of Systemic Lupus Erythematosus

1974 • 113 citations

The role of adrenocortical steroids in infection, immunity and hypersensitivity.

1956 • 112 citations

AUTOIMMUNE MECHANISMS IN HUMAN VASCULAR DISEASE

1974 • 111 citations

Detection and radioassay of soluble circulating immune complexes using guinea pig peritoneal exudate cells

1974 • 104 citations

Rheumatoid synovitis. An extravascular immune complex disease

1974 • 104 citations

STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS

1963 • 102 citations

Nephropathy associated with sickle cell anemia: An autologous immune complex nephritis

1975 • 102 citations

INTERSTITIAL IMMUNE COMPLEX THYROIDITIS IN MICE

1974 • 98 citations

Pathoanatomic, pathophysiologic and clinical correlations in endocarditis (first of two parts).

1974 • 97 citations

DISAPPEARANCE OF IMMUNOGLOBULIN AND COMPLEMENT FROM THE ARTHUS REACTION AND ITS RELEVANCE TO STUDIES OF VASCULITIS IN MAN

1971 • 95 citations

COMPLEMENT-DEPENDENT B-CELL ACTIVATION BY COBRA VENOM FACTOR AND OTHER MITOGENS?

1974 • 95 citations

Experimental skin lesions in mice resembling systemic lupus erythematosus

1973 • 94 citations

Evidence for circulating immune complexes in sarcoidosis.

1974 • 93 citations

Cryopathies: A Review

1961 • 92 citations

Relation of cellular infiltration of rheumatoid synovial membrane to its immune response

1974 • 89 citations

Leukotactic factors in health and disease.

1971 • 87 citations

Primer on the Rheumatic Diseases

1973 • 80 citations

Gamma Globulin and Molecular Mechanisms in Hypersensitivity Reactions*

2015 • 79 citations

Immunological Characterization of Lymphocytes in Synovial Fluid from Patients with Rheumatoid Arthritis

1973 • 78 citations

IMMUNOFLUORESCENCE OF THE SKIN: THE INTERPRETATION OF THE STAINING OF BLOOD VESSELS AND CONNECTIVE TISSUE AIDED BY NEW TECHNIQUES

1970 • 77 citations

Systemic Lupus Erythematosus

1975 • 77 citations

The Release of DNA into Serum and Synovial Fluid

1971 • 76 citations

Effect of Cortisone on the Disappearance Kinetics and Tissue Localization of Soluble Immune Complexes

1975 • 75 citations

Evidence for Circulating Immune Complexes in Thyroid Disease

1974 • 74 citations

Ultrastructure of Immune Deposits in Renal Glomeruli

1972 • 72 citations

Rheumatoid hyperviscosity syndrome

1970 • 72 citations

Pathoanatomic, Pathophysiologic and Clinical Correlations in Endocarditis

1974 • 72 citations

Studies on vasculitis

1971 • 72 citations

Glomerular Complement Components in Human Glomerulonephritis

1974 • 72 citations

Immune Complex Diseases

1972 • 71 citations

Viruses and Systemic Lupus Erythematosus

1975 • 70 citations

A Radioimmunoassay for Human Antigen-Antibody Complexes in Clinical Material

1975 • 69 citations

Glomerulitis in Typhoid Fever

1974 • 68 citations

Response of the lung to inhaled antigens

1974 • 66 citations

Progress in allergy. Introduction.

1962 • 65 citations

A unique influence of cortisone on the transit of specific macromolecules across vascular walls in immune complex disease.

1968 • 65 citations

Aggregation of human blood platelets by immune complexes in the sedimentation pattern test.

1973 • 63 citations

Immunochemical conditions affecting the measurement of DNA antibodies using ammonium sulfate precipitation

1971 • 58 citations

IMMUNOFLUORESCENT STUDIES OF THE SKIN IN CRYGLOBULINAEMIC VASCULITIS

1971 • 55 citations

THE VALUE OF IMMUNOFLUORESCENCE IN THE STUDY OF HUMAN RENAL DISEASE

1971 • 55 citations

Cryoglobulins in glomerulonephritis not related to systemic disease

1973 • 50 citations

Presence of C1q-reactive immune complexes in patients with leprosy.

1972 • 50 citations

Cryoglobulins. II. The Biological and Chemical Properties of Cryoproteins in Acute Post-Streptococcal Glomerulonephritis

1971 • 49 citations

Immunopathology and Glomerulonephritis

1974 • 47 citations

Specific concentration of antilymphocyte antibodies in the serum cryoprecipitates of patients with systemic lupus erythematosus.

1975 • 47 citations

Immunoglobulin deposits in skin in systemic lupus erythematosus

1975 • 44 citations

Infectious virus-antibody complexes: interaction with anti-immunoglobulins, complement, and rheumatoid factor.

1971 • 44 citations

Cryoglobulins in acute and chronic liver diseases.

1974 • 42 citations

Pathophysiology of rheumatoid arthritis.

1973 • 42 citations

Subclinical immune complexes in the glomeruli of kidneys postmortem

1974 • 39 citations

INFECTIOUS VIRUS-ANTIBODY COMPLEXES: INTERACTION WITH ANTI-IMMUNOGLOBULINS, COMPLEMENT, AND RHEUMATOID FACTOR

1971 • 39 citations

IgA-IgG cryoglobulinaemia with vasculitis.

1971 • 38 citations

Polymorphonuclear leukocyte stimulation by immune complexes. Assessment by nitroblue tetrazolium dye reduction

1973 • 38 citations

RENAL DEPOSITION OF SOLUBLE IMMUNE COMPLEXES IN MICE BEARING B-16 MELANOMA

1974 • 36 citations

COMPLEMENT AND COAGULATION

1975 • 35 citations

Reaction of Rheumatoid Sera with Fragments of Papain-Digested Rabbit Gamma Globulin.

1961 • 34 citations

THE MALARIA PROBLEM IN AUSTRALIA AND THE AUSTRALIAN PACIFIC TERRITORIES

1950 • 32 citations

Studies into the occurrence of soluble antigen-antibody complexes in disease. 3. Rheumatoid arthritis and other human diseases.

1968 • 32 citations

Inhibition of complement‐dependent lymphocyte rosette formation: a possible test for activated complement products

1974 • 31 citations

INVESTIGATIONS INTO THE PATHOGENESIS OF ACUTE CUTANEOUS ANGIITIS

1970 • 31 citations

SOLUBLE-COMPLEX FORMATION AFTER MYOCARDIAL INFARCTION

1974 • 30 citations

Studies into the occurrence of soluble antigen--antibody complexes in disease. I. A biological assay for soluble complexes.

1968 • 30 citations

Circulating immune complexes in retinal vasculitis.

1977 • 29 citations

Mediators of the Arthus and Related Reactions*

2015 • 23 citations

Comparison of the Ocular Effects of Circulating Endotoxin and Immune Complexes: Role of Vasoactive Amines

1975 • 21 citations

THE DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS

1973 • 20 citations

Anticomplementary sera in cutaneous vasculitis

1973 • 20 citations

Anti-Inflammatory Agents

1965 • 19 citations

C1Q Precipitin in the Sera of Patients with Allergic Vasculitis (Gougerot-Ruiter Syndrome)

1975 • 19 citations

Hageman-factor-dependent coagulation, fibrinolysis, and kinin generation.

1974 • 18 citations

Clinical and Laboratory Double-blind Investigation on Effect of Fibrinolytic Therapy in Patients with Cutaneous Vasculitis

1973 • 18 citations

Stimulation of gamma-globulin synthesis and specific antibody production by a factor released by activated lymphocytes.

1973 • 17 citations

Immunotherapy of Human Cancer (Part 1 of 3)

1973 • 16 citations

Mediators of the Arthus and Related Reactions (Part 1 of 2)

1967 • 15 citations

Prevention of immune complex disease (Serum Sickness) by antagonists of vasoactive amines

1971 • 15 citations

Complement-dependent platelet and polymorphonuclear leukocyte reactions.

1974 • 15 citations

FUNCTIONAL ROLE OF CHOLESTEROL IN INFECTION AND AUTOIMMUNITY

1975 • 12 citations

Stimulation of γ-Globulin Synthesis and Specific Antibody Production by a Factor Released by Activated Lymphocytes

1973 • 12 citations

The Participation of Cells in the Inflammatory Injury of tissue

1975 • 12 citations

Mixed IgG-IgA Cryoglobulinemia in Human Serum Sickness

1975 • 9 citations

Assay and characterization of polyanion--immunoglobulin complexes in sera of New Zealand Black mice.

1974 • 8 citations

Studies with human leukocyte lysosomes. Evidence for antilysosome antibodies in lupus erythematosus and for the presence of lysosomal antigen in inflammatory diseases.

1975 • 8 citations

Immunotherapy of human cancer

1980 • 4 citations

The role and character of immunoglobulins in rheumatoid inflammation.

1973 • 4 citations

THE " RHEUMATIC DISEASE."

1928 • 3 citations

Fibrinolysis in cutaneous vasculitis.

1971 • 3 citations

Non-renal Neoplasms and the Kidney

1975 • 2 citations

Immunological aspects of small vessel disease.

1975 • 1 citations

Immunological aspects of small vessel disease.

1975 • 1 citations

Immunological aspects of the etiology of human leukemia.

1974 • 1 citations