Effect of Tyrosine Kinase Inhibitors on Clathrin-coated Pit Recruitment and Internalization of Epidermal Growth Factor Receptor

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

The EGF receptor family as targets for cancer therapy

2000 • 1,339 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

1994 • 800 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function

1999 • 633 citations

The β ₂ -adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

1999 • 615 citations

SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling

2000 • 577 citations

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.

1979 • 528 citations

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

2001 • 487 citations

Mechanism of biological synergy between cellular Src and epidermal growth factor receptor

1999 • 468 citations

From TCR Engagement to T Cell Activation

1999 • 379 citations

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

1978 • 358 citations

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1989 • 356 citations

EGF Receptor Signaling Stimulates SRC Kinase Phosphorylation of Clathrin, Influencing Clathrin Redistribution and EGF Uptake

1999 • 347 citations

Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

2001 • 316 citations

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

1991 • 288 citations

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

1999 • 259 citations

Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies

1988 • 248 citations

Molecular cloning of the a1 locus of Zea mays using the transposable elements En and Mu1

1985 • 246 citations

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.

1988 • 236 citations

Endocytosis of Functional Epidermal Growth Factor Receptor-Green Fluorescent Protein Chimera

1998 • 228 citations

Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.

1990 • 207 citations

PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.

1997 • 205 citations

Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes

1984 • 174 citations

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts.

1982 • 171 citations

Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.

1991 • 166 citations

Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors.

1992 • 150 citations

Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway

1998 • 149 citations

Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase.

1995 • 147 citations

A role for the cytoplasmic domain in transferrin receptor sorting and coated pit formation during endocytosis

1988 • 140 citations

Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.

1994 • 138 citations

Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis

2000 • 135 citations

Transferrin receptors promote the formation of clathrin lattices

1991 • 122 citations

Tyrosine Kinase Inhibitors. 10. Isomeric 4-[(3-Bromophenyl)amino]pyrido[d]- pyrimidines Are Potent ATP Binding Site Inhibitors of the Tyrosine Kinase Function of the Epidermal Growth Factor Receptor

1996 • 116 citations

Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis

1991 • 114 citations

Lysosomal Targeting of Epidermal Growth Factor Receptors via a Kinase-dependent Pathway Is Mediated by the Receptor Carboxyl-terminal Residues 1022-1123

1996 • 108 citations

Divergence of epidermal growth factor and transferrin during receptor-mediated endocytosis

1983 • 104 citations

Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region.

1991 • 103 citations

Kinetics of binding, endocytosis, and recycling of EGF receptor mutants

1992 • 100 citations

Lateral diffusion of epidermal growth factor complexed to its surface receptors does not account for the thermal sensitivity of patch formation and endocytosis

1982 • 93 citations

Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines

1991 • 88 citations

Mitogen-activated protein kinase stimulation by a tyrosine kinase-negative epidermal growth factor receptor.

1993 • 75 citations

The role of kinase activity and the kinase insert region in ligand-induced internalization and degradation of the c-fms protein.

1991 • 75 citations

An Incomplete Program of Cellular Tyrosine Phosphorylations Induced by Kinase-defective Epidermal Growth Factor Receptors

1995 • 71 citations

A kinase-negative epidermal growth factor receptor that retains the capacity to stimulate DNA synthesis.

1994 • 56 citations

A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor beta-receptor is critical for ligand-mediated endocytosis.

1994 • 45 citations

Inhibition of tyrosine kinase and epidermal growth factor receptor internalization by lavendustin A methyl ester in cultured A431 cells.

1990 • 34 citations

Tyrosine phosphorylation of ras GTPase-activating protein does not require association with the epidermal growth factor receptor.

1993 • 33 citations

Stimulation of Mitogenic Pathways through Kinase-Impaired Mutants of the Epidermal Growth Factor Receptor

2001 • 15 citations

Clinical trials referral resource. Epidermal growth factor receptor inhibitors in clinical trials.

2001 • 6 citations