Effects of Alzheimer's Disease and Normal Aging on Cerebrospinal Fluid Norepinephrine Responses to Yohimbine and Clonidine

“Mini-mental state”

1975 • 82,784 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

The Brief Psychiatric Rating Scale

1962 • 10,683 citations

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1971 • 1,671 citations

Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia

1982 • 677 citations

Abnormal Noradrenergic Function in Posttraumatic Stress Disorder

1993 • 566 citations

Plasma Catecholamines in Stress and Exercise

1980 • 513 citations

Cell loss in the locus coeruleus in senile dementia of Alzheimer type

1981 • 443 citations

Autonomic and psychic effects of yohimbine hydrochloride

1961 • 302 citations

Blood-Brain Barrier for Adrenaline

1959 • 301 citations

A Quantitative Study of the Pigmented Neurons in the Nuclei Locus Coeruleus and Subcoeruleus in Man as Related to Aging

1979 • 299 citations

Biochemical changes in Dementia disorders of Alzheimer type (AD/SDAT)

1983 • 296 citations

Changes in the Monoamine Containing Neurones of the Human Cns in Senile Dementia

1980 • 272 citations

Aminergic systems in Alzheimer's disease and Parkinson's disease

1987 • 241 citations

Locus coeruleus projections to cortex: Topography, morphology and collateralization

1982 • 214 citations

Relation Between Plasma and Cerebrospinal Fluid Levels of 3-Methoxy-4-Hydroxyphenylglycol

1983 • 203 citations

Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease

1987 • 185 citations

Comparison of double- and single-isotope enzymatic derivative methods for measuring catecholamines in human plasma.

1978 • 183 citations

Regulation of locus coeruleus neurons and splanchnic, sympathetic nerves by cardiovascular afferents

1984 • 176 citations

The Brief Psychiatric Rating Scale (BPRS) in Geropsychiatric Research: I. Factor Structure on an Inpatient Unit

1984 • 165 citations

Adrenergic Receptors in Aging and Alzheimer's Disease: Increased β₂‐Receptors in Prefrontal Cortex and Hippocampus

1989 • 162 citations

Propranolol in the treatment of rage and violent behavior in patients with chronic brain syndromes

1981 • 161 citations

Norepinephrine and MHPG Levels in CSF and Plasma in Alzheimer's Disease

1984 • 153 citations

Noradrenergic neuronal dysregulation in panic disorder: the effects of intravenous yohimbine and clonidine in panic disorder patients

1992 • 148 citations

Relationship between norepinephrine in blood and cerebrospinal fluid in the presence of a blood cerebrospinal fluid barrier for norepinephrine

1977 • 136 citations

Influence of yohimbine on blood pressure, autonomic reflexes, and plasma catecholamines in humans.

1983 • 123 citations

Neurochemical aspects on aging and diseases with cognitive impairment

1990 • 104 citations

Short and long term changes in tyrosine hydroxylase activity in rat brain after subtotal destruction of central noradrenergic neurons

1981 • 101 citations

Development and plasticity of the locus coeruleus: A review of recent physiological and pharmacological experimentation

1990 • 95 citations

Cerebrospinal Fluid Vasopressin, Oxytocin, sopressin, Oxytoc in Alzheimer's Diseasβ-Endorphin

1986 • 90 citations

Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine

1993 • 74 citations

Monoamine metabolite concentrations in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.

1984 • 72 citations

Subtotal destruction of central noradrenergic projections increases the firing rate of locus coeruleus cells

1983 • 72 citations

Propranolol for the Control of Disruptive Behavior in Senile Dementia

1988 • 62 citations

Autonomic dysfunction in patients with dementia of the Alzheimer type

1993 • 60 citations

Concentration of monoamines and their metabolites in the cerebrospinal fluid from patients with senile dementia of the Alzheimer type and vascular dementia of the Binswanger type

1992 • 59 citations

Significance of decreased lumbar CSF levels of HVA and 5-HIAA in Alzheimer's disease

1992 • 57 citations

Central amine metabolism in Alzheimer's disease: In vivo relationship to cognitive deficit

1981 • 56 citations

Development of a RIA for clonidine and its comparison with the reference methods

1981 • 55 citations

Innervation of human hippocampus by noradrenergic systems: Normal anatomy and structural abnormalities in aging and in Alzheimer's disease

1988 • 50 citations

Biological correlates of clinical heterogeneity in primary dementia

1992 • 50 citations

Increased Plasma and Cerebrospinal Fluid Norepinephrine in Older Men: Differential Suppression by Clonidine*

1988 • 48 citations

Age and Alpha-2 Adrenergic Regulation of Plasma Norepinephrine Kinetics in Humans

1987 • 46 citations

Effects of Yohimbine on Human Sympathetic Nervous System Function*

1991 • 45 citations

Sprouting of noradrenergic fibers in hippocampus after medial septal lesions: Contributions of the central and peripheral nervous systems

1983 • 45 citations

Age-related differences in norepinephrine kinetics: effect of posture and sodium-restricted diet.

1990 • 44 citations

Determination of yohimbine and its two hydroxylated metabolites in humans by high-performance liquid chromatography and mass spectral analysis

1992 • 38 citations

Clonidine Decreases Plasma and Cerebrospinal Fluid Arginine Vasopressin but Not Oxytocin in Humans

1987 • 33 citations

α₂‐Adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine

1993 • 30 citations

Yohimbine Increases Cerebrospinal Fluid and Plasma Norepinephrine but Not Arginine Vasopressin in Humans

1989 • 29 citations

Peripheral sympathectomy and adrenal medullectomy do not alter cerebrospinal fluid norepinephrine

1986 • 28 citations

Clonidine reduces elevated cerebrospinal fluid catecholamine levels in patients with essential hypertension

1984 • 19 citations

A Pilot Study of Oral Physostigmine Plus Yohimbine in Patients with Alzheimer Disease

1993 • 18 citations

Neuropsychological test performance and CSF levels of monoamine metabolites in healthy volunteers and patients with Alzheimer's dementia

1987 • 14 citations

Noradrenergic response to intravenous yohimbine in patients with depression and comorbidity of depression and panic

1993 • 9 citations

Deleted Work

1955 • 0 citations