Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only

Global Cancer Statistics, 2002

2005 • 17,966 citations

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

1999 • 8,737 citations

Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer

2003 • 6,072 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

The causal relation between human papillomavirus and cervical cancer

2002 • 3,451 citations

Classification of papillomaviruses

2004 • 3,098 citations

Sustained efficacy up to 4·5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial

2006 • 1,766 citations

Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial

2004 • 1,624 citations

A Controlled Trial of a Human Papillomavirus Type 16 Vaccine

2002 • 1,570 citations

Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial

2005 • 1,551 citations

Toll-like receptors control activation of adaptive immune responses

2001 • 1,374 citations

Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells

2002 • 1,305 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

Against which human papillomavirus types shall we vaccinate and screen? the international perspective

2004 • 1,099 citations

Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic.

1992 • 1,086 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

Glycoprotein-D–Adjuvant Vaccine to Prevent Genital Herpes

2002 • 772 citations

Control of B-cell responses by Toll-like receptors

2005 • 732 citations

Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas.

1995 • 683 citations

Carcinogenicity of human papillomaviruses

2005 • 678 citations

Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox Vaccination

2003 • 666 citations

Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection

1995 • 597 citations

The carcinogenicity of human papillomavirus types reflects viral evolution

2005 • 552 citations

Targeting the innate immune response with improved vaccine adjuvants

2005 • 537 citations

Efficacy of Human Papillomavirus-16 Vaccine to Prevent Cervical Intraepithelial Neoplasia

2006 • 452 citations

Vaccine induced immunologic memory for hepatitis B surface antigen: implications for policy on booster vaccination

1996 • 376 citations

Toll-Like Receptor 4, But Not Toll-Like Receptor 2, Is a Signaling Receptor forEscherichiaandSalmonellaLipopolysaccharides

2000 • 352 citations

Reactivity of human sera in a sensitive, high-throughput pseudovirus-based papillomavirus neutralization assay for HPV16 and HPV18

2004 • 345 citations

Virus-like Particles of Bovine Papillomavirus Type 4 in Prophylactic and Therapeutic Immunization

1996 • 318 citations

Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women

1997 • 292 citations

Monophosphoryl lipid A as an adjuvant. Past experiences and new directions.

1995 • 283 citations

Papillomavirus-Like Particles Induce Acute Activation of Dendritic Cells

2001 • 254 citations

Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents

2004 • 253 citations

Promotion of B Cell Immune Responses via an Alum-Induced Myeloid Cell Population

2004 • 251 citations

Surface Conformational and Linear Epitopes on HPV-16 and HPV-18 L1 Virus-like Particles as Defined by Monoclonal Antibodies

1996 • 251 citations

Vaccination against human papillomavirus infection: a new paradigm in cervical cancer control

2005 • 246 citations

The Common Vaccine Adjuvant Aluminum Hydroxide Up-Regulates Accessory Properties of Human Monocytes via an Interleukin-4-Dependent Mechanism

2001 • 239 citations

Immunization with viruslike particles induces long-term protection of rabbits against challenge with cottontail rabbit papillomavirus

1996 • 221 citations

A Phase 1 Study of a Recombinant Viruslike Particle Vaccine against Human Papillomavirus Type 11 in Healthy Adult Volunteers

2001 • 193 citations

Monophosphoryl Lipid A Activates Both Human Dendritic Cells and T Cells

2002 • 182 citations

The adjuvant monophosphoryl lipid A increases the function of antigen-presenting cells

2000 • 179 citations

Role of Innate Immune Factors in the Adjuvant Activity of Monophosphoryl Lipid A

2003 • 176 citations

Cellular Immune Responses to Human Papillomavirus (HPV)–16 L1 in Healthy Volunteers Immunized with Recombinant HPV‐16 L1 Virus‐Like Particles

2003 • 169 citations

Vaccination with yeast-expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from CRPV-induced papilloma formation

1995 • 167 citations

Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system

1998 • 158 citations

Assembled baculovirus-expressed human papillomavirus type 11 L1 capsid protein virus-like particles are recognized by neutralizing monoclonal antibodies and induce high titres of neutralizing antibodies

1994 • 151 citations

Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type

2004 • 151 citations

Effective vaccination against papilloma development by immunization with L1 or L2 structural protein of cottontail rabbit papillomavirus

1992 • 150 citations

Human papillomavirus (HPV) type 11 recombinant virus-like particles induce the formation of neutralizing antibodies and detect HPV-specific antibodies in human sera

1994 • 149 citations

Antigen dependent and independent mechanisms that sustain serum antibody levels

2003 • 141 citations

Human Papillomavirus Type 11 (HPV‐11) Neutralizing Antibodies in the Serum and Genital Mucosal Secretions of African Green Monkeys Immunized with HPV‐11 Virus‐like Particles Expressed in Yeast

1997 • 134 citations

Three-dimensional structure of vaccinia virus-produced human papillomavirus type 1 capsids

1994 • 133 citations

Papillomavirus-Like Particles Stimulate Murine Bone Marrow-Derived Dendritic Cells To Produce Alpha Interferon and Th1 Immune Responses via MyD88

2004 • 124 citations

Herpes Simplex Virus (HSV) Type 2 Glycoprotein D Subunit Vaccines and Protection against Genital HSV‐1 or HSV‐2 Disease in Guinea Pigs

2003 • 114 citations

Control of IL-12 and IFN-gamma production in response to live or dead bacteria by TNF and other factors.

1998 • 112 citations

Safety and immunogenicity profile of an experimental hepatitis B vaccine adjuvanted with AS04

2004 • 101 citations

A monoclonal antibody against intact human papillomavirus type 16 capsids blocks the serological reactivity of most human sera.

1997 • 91 citations

B Lymphocyte Activation by Human Papillomavirus-Like Particles Directly Induces Ig Class Switch Recombination via TLR4-MyD88

2005 • 82 citations

Interaction of papillomavirus virus-like particles with human myeloid antigen-presenting cells

2003 • 79 citations

Analysis of the maturation process of dendritic cells deficient for TNF and lymphotoxin-α reveals an essential role for TNF

2003 • 78 citations

Safety and Immunogenicity of Glycoprotein D--Adjuvant Genital Herpes Vaccine

2005 • 77 citations

HPV-16 L1 VLP vaccine elicits a broad-spectrum of cytokine responses in whole blood

2005 • 75 citations

Immunopotentiatiors in modern vaccines

2003 • 68 citations

Systemic and Secretory Humoral Immunity in the Normal Human Vaginal Tract

1995 • 60 citations

Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6, 11, 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvant

2005 • 54 citations

Immunological Foundations to the Quest for New Vaccine Adjuvants

2004 • 49 citations

Activity of Monosaccharide Lipid A Analogues in Human Monocytic Cells as Agonists or Antagonists of Bacterial Lipopolysaccharide

1999 • 39 citations

Persistence of antibody and immunologic memory in children immunized with hepatitis B vaccine at birth

2002 • 34 citations

T cell and interferon-gamma involvement in the adjuvant action of a detoxified endotoxin.

1989 • 34 citations

Host factors impacting the innate response in humans to the candidate adjuvants RC529 and monophosphoryl lipid A

2003 • 34 citations

Anamnestic response to administration of purified non-adsorbed hepatitis B surface antigen in healthy responders to hepatitis B vaccine with long-term non-protective antibody titres

2002 • 30 citations

Efficacy of Human Papillomavirus-16 Vaccine to Prevent Cervical Intraepithelial Neoplasia

2006 • 26 citations