Benzodiazepine Dependence A Review of the Evidence

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Benzodiazepine Receptor: Demonstration in the Central Nervous System

1977 • 1,705 citations

Tolerance to, and dependence on, some non-opiate psychotropic drugs.

1971 • 761 citations

Withdrawal from long-term benzodiazepine treatment.

1981 • 368 citations

Withdrawal reactions from chlordiazepoxide (?Librium?)

1961 • 340 citations

Increased sensitivity to nitrazepam in old age.

1977 • 323 citations

Benzodiazepines in Clinical Practice

1974 • 317 citations

BENZODIAZEPINE WITHDRAWAL SYMPTOMS AND PROPRANOLOL

1981 • 298 citations

The psychosedative properties of methaminodiazepoxide.

1960 • 245 citations

Pharmacological and clinical studies on Valium (T.M.) a new psychotherapeutic agent of the benzodiazepine class.

1961 • 242 citations

Use of medicines in general practice.

1977 • 216 citations

CHRONIC BARBITURATE INTOXICATION

1950 • 189 citations

LENGTH OF TREATMENT WITH ANXIOLYTIC SEDATIVES AND RESPONSE TO THEIR SUDDEN WITHDRAWAL

1973 • 163 citations

Withdrawal Reaction From Long-term, Low-dosage Administration of Diazepam

1980 • 158 citations

The Prognosis of Affective Disorders: the Differentiation of Anxiety States from Depressive Illnesses

1972 • 144 citations

Dependence liability of several sedative-hypnotic agents evaluated in monkeys.

1973 • 141 citations

Rebound insomnia. A potential hazard following withdrawal of certain benzodiazepines

1979 • 137 citations

Quinazolines and 1,4-Benzodiazepines. IV.^1,2 Transformations of 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-Oxide³

1961 • 113 citations

Psychotropic Drugs in Use Today

1973 • 112 citations

No changes in rat benzodiazepine receptors after withdrawal from continuous treatment with lorazepam and diazepam

1979 • 110 citations

Benzodiazepines and withdrawal psychosis. Report of three cases.

1977 • 108 citations

Chlordiazepoxide loses its anxiolytic action with long-term treatment

1979 • 107 citations

Self-injection of barbiturates and benzodiazepines in baboons

1981 • 106 citations

Misuse and Abuse of Diazepam: An Increasingly Common Medical Problem

1975 • 93 citations

Rapid Recovery From Massive Diazepam Overdose

1978 • 93 citations

New Psychotherapeutic Agent, Chlordiazepoxide

1960 • 90 citations

Abrupt Withdrawal From Therapeutically Administered Diazepam

1978 • 90 citations

Plasma diazepam and desmethyldiazepam concentrations during long‐term diazepam therapy.

1981 • 83 citations

Benzodiazepines: behavioral and neurochemical mechanisms

1977 • 80 citations

Minor Tranquilizers

1978 • 79 citations

Chlordiazepoxide withdrawal in the neonate

1976 • 73 citations

Factors affecting the consumption of psychotropic drugs

1981 • 69 citations

Addiction to Diazepam

1976 • 68 citations

The concentrations of diazepam and its metabolites in the plasma after an acute and chronic administration

1974 • 67 citations

Pills for personal problems.

1975 • 63 citations

Brain mechanisms associated with therapeutic actions of benzodiazepines: focus on neurotransmitters

1977 • 62 citations

Lorazepam withdrawal seizures.

1980 • 57 citations

Withdrawal Reaction to Diazepam

1976 • 54 citations

Diazepam withdrawal syndrome: a case with psychosis, seizure, and coma

1979 • 53 citations

Use of diazepam in treatment of severe convulsive status epilepticus.

1967 • 52 citations

Serum growth hormone, serum immunoreactive insulin and blood glucose response to oral and intravenous diazepam in man.

1975 • 50 citations

Diazepam on Demand

1974 • 44 citations

Possible neonatal diazepam withdrawal: A case report

1977 • 43 citations

Development of morphine dependence in rats: Lack of effect of previous ingestion of other drugs

1971 • 43 citations

Diazepam withdrawal psychosis: a case report

1977 • 41 citations

METHAMINODIAZEPOXIDE

1960 • 40 citations

THE BENZODIAZEPINE BONANZA

1974 • 36 citations

Long-Term Sleep Laboratory Evaluation of Flunitrazepam

1979 • 34 citations

Comparative efficacy of tofisopam and placebo

1979 • 31 citations

Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy.

1978 • 29 citations

Benzodiazepine Withdrawal

1981 • 26 citations

Addiction to Diazepam (Valium)

1967 • 22 citations

A case report of lorazepam withdrawal

1980 • 22 citations

The benzodiazepines--use and abuse.

1980 • 21 citations

A neuroendocrine approach to benzodiazepine tolerance and dependence.

1981 • 19 citations

Diazepam (Valium) Detoxification

1979 • 19 citations

A critique of overemphasis on side effects with the psychotropic drugs: an analysis of 18,000 chlordiazepoxide-treated cases.

1966 • 19 citations

Long-term psychotropic drug-taking and the process of withdrawal

1981 • 18 citations

Case report: A Delirious Abstinence Syndrome associated with Clorazepate (Tranxilen^R)

1978 • 16 citations

Dependence-Producing Effects of Anxiolytics

1981 • 14 citations

Benzodiazepines: Some Aspects of Their Clinical Pharmacology

1980 • 14 citations

RAPID HABITUATION TO CHLORDIAZEPOXIDE (“LIBRIUM”)

1963 • 13 citations

Suspected dependence on chlordiazepoxide hydrochloride (Librium).

1966 • 12 citations

The Role of Diazepam (Valium) In Emotional Illness

1965 • 9 citations

Auditory screening of school children: fact or fallacy?

1982 • 6 citations

Anxiety caused by a short-life hypnotic

1982 • 5 citations

[The addiction potential of benzodiazepines. Application of the results of treatment of alcohol withdrawal syndrome].

1981 • 3 citations

[Benzodiazepine physical dependence. 6 cases (author's transl)].

1980 • 2 citations

Use of Intravenous Diazepam in Acute Skeletal Muscle Spasm Preliminary Report

1964 • 1 citations